Month: June 2017

Scientists Find New Biomarker to Guide Cancer Immunotherapy

Scientists said on Monday they had pinpointed a particular type of immune system cell that could predict more precisely if cancer patients are likely to respond to modern immunotherapy medicines.

The discovery, reported in the journal Nature Immunology, suggests doctors and drug developers will need to get smarter in zeroing in on those people who stand to benefit from the expensive new drugs, which are revolutionizing cancer care.

Drugs such as Merck’s Keytruda, Bristol-Myers Squibb’s Opdivo, Roche’s Tecentriq and AstraZeneca’s Imfinzi can boost the immune system’s ability to fight tumors, but they only work for some patients.

The current widely used benchmark when giving cancer immunotherapy is a protein called PDL-1. However, many experts view PDL-1 as a “blunt instrument”, since it does not match precisely to drug response, leading to the consideration of other measures, such as the level of mutation in tumors.

The latest research adds a further twist by highlighting therole of so-called tissue-resident memory T-cells.

Researchers from the University of Southampton and La Jolla Institute for Allergy and Immunology found that lung cancer patients with lots of this cell type in their tumors were 34 percent less likely to die than others.

“Having made the first baby steps with PDL-1 testing, we need to be smarter by using new tests,” said Christian Ottensmeier, a Cancer Research UK scientist who worked on the study.

“PDL-1 testing is a little bit like saying ‘you’ve got a Ferrari because it is red.’ Many Ferraris are red and many tumors that are PDL-1 positive will respond to immunotherapy, but on its own that is not sufficient.”

Ottensmeier and colleagues now plan further clinical trials to see how well their biological predictor can pick out patients who will benefit from taking Opdivo.

Industry analysts expect the new generation of cancer immunotherapy drugs to generate tens of billions of dollars in annual sales by early next decade, with lung cancer the biggest single market.

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AI Becoming an Increasingly Valuable Health Tool

Artificial intelligence is turning out to be a useful tool for doctors who are increasingly using complex algorithms to help them diagnose disease, and even create new drugs. VOA’s Kevin Enochs reports.

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3-year Global Coral Bleaching Event Easing, But Still Bad

A mass bleaching of coral reefs worldwide is finally easing after three years, U.S. scientists announced Monday.

About three-quarters of the world’s delicate coral reefs were damaged or killed by hot water in what scientists say was the largest coral catastrophe.

The National Oceanic and Atmospheric Administration announced a global bleaching event in May 2014. It was worse than previous global bleaching events in 1998 and 2010.

The forecast damage doesn’t look widespread in the Indian Ocean, so the event loses its global scope. Bleaching will still be bad in the Caribbean and Pacific, but it’ll be less severe than recent years, said NOAA coral reef watch coordinator C. Mark Eakin.

Places like Australia’s Great Barrier Reef, northwest Hawaii, Guam and parts of the Caribbean have been hit with back-to-back-to-back destruction, Eakin said.

University of Victoria, British Columbia, coral reef scientist Julia Baum plans to travel to Christmas Island in the Pacific where the coral reefs have looked like ghost towns in recent years.

“This is really good news,” Baum said. “We’ve been totally focused on coming out of the carnage of the 2015-2016 El Nino.”

While conditions are improving, it’s too early to celebrate, said Eakin, adding that the world may be at a new normal where reefs are barely able to survive during good conditions.

Eakin said coral have difficulty surviving water already getting warmer by man-made climate change. Extra heating of the water from a natural El Nino nudges coral conditions over the edge.

About one billion people use coral reefs for fisheries or tourism. Scientists have said that coral reefs are one of the first and most prominent indicators of global warming.

“I don’t see how they can take one more hit at this point,” Baum said. “They need a reprieve.”

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Science Says: DNA Shows Early Spread of Cats in Human World

Long before cats became the darlings of Facebook and YouTube, they spread through the ancient human world.

A DNA study reached back thousands of years to track that conquest and found evidence of two major dispersals from the Middle East, in which people evidently took cats with them. Genetic signatures the felines had on those journeys are still seen in most modern-day breeds.

Researchers analyzed DNA from 209 ancient cats as old as 9,000 years from Europe, Africa and Asia, including some ancient Egyptian cat mummies.

“They are direct witnesses of the situation in the past,” said Eva-Maria Geigl of the Jacques Monod Institute in Paris. She and colleagues also looked at 28 modern feral cats from Bulgaria and east Africa.

It’s the latest glimpse into the complicated story of domesticated cats. They are descendants of wild ancestors that learned to live with people and became relatively tame – though some cat owners would say that nowadays, they don’t always seem enthusiastic about our company.

The domestication process may have begun around 10,000 years ago when people settled in the Fertile Crescent, the arch-shaped region that includes the eastern shore of the Mediterranean Sea and land around the Tigris and Euphrates rivers. They stored grain, which drew rodents, which in turn attracted wild cats. Animal remains in trash heaps might have attracted them too. Over time, these wild felines adapted to this man-made environment and got used to hanging around people.

Previous study had found a cat buried alongside a human some 9,500 years ago in Cyprus, an island without any native population of felines. That indicates the cat was brought by boat and it had some special relationship to that person, researchers say.

Cats were clearly tame by about 3,500 years ago in Egypt, where paintings often placed them beneath chairs. That shows by that time, “the cat makes its way to the household,” said Geigl.

But the overall domestication process has been hard for scientists to track, in part because fossils skeletons don’t reveal whether a cat was wild or domesticated.

It’s easier to distinguish dogs, our first domesticated animal, from their wolf ancestors. Dogs evolved from wolves that had begun to associate with people even before farming began, perhaps drawn by the food the humans left behind.

The new study tracked the spread of specific cat DNA markers over long distances through time, a sign that people had taken cats with them. Results were released Monday by the journal Nature Ecology & Evolution.

The study “strengthens and refines previous work,” said Carlos Driscoll of the Wildlife Institute of India. The extensive sampling of cat DNA going back so far in time is unprecedented, he said.

Researchers also looked for a genetic variant that produces the blotchy coat pattern typical of modern-day domestic cats, rather than the tiger-like stripes seen in their wild cousins.  It showed up more often in samples from after the year 1300 than earlier ones, which fits with other evidence that the tabby cat markings became common by the 1700s and that people started breeding cats for their appearance in the 1800s. 

That’s late in the domestication of cats, in contrast to horses, which were bred for their appearance early on, Geigl said. 

Most of the study focused on the ancient dispersals of cats. In the DNA samples analyzed, one genetic signature found first in the Asian portion of Turkey – and perhaps once carried by some Fertile Crescent cats – showed up more than 6,000 years ago in Bulgaria.

That indicates cats had been taken there by boat with the first farmers colonizing Europe, Geigl said. It also appeared more than 5,000 years ago in Romania, as well as around 3,000 years ago in Greece.

A second genetic signature, first seen in Egypt, had reached Europe between the first and fifth centuries, as shown by a sample from Bulgaria. It was found in a seventh-century sample from a Viking trading port in northern Europe, and an eighth-century sample from Iran.

The dispersal of the cats across the Mediterranean was probably encouraged by their usefulness in controlling rodents and other pests on ships, the researchers said.

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Too Hot to Handle: Study Shows Earth’s Killer Heat Worsens

Killer heat is getting worse, a new study shows.

Deadly heat waves like the one now broiling the American West are bigger killers than previously thought and they are going to grow more frequent, according to a new comprehensive study of fatal heat conditions. Still, those stretches may be less lethal in the future, as people become accustomed to them.

A team of researchers examined 1,949 deadly heat waves from around the world since 1980 to look for trends, define when heat is so severe it kills and forecast the future. They found that nearly one in three people now experience 20 days a year when the heat reaches deadly levels. But the study predicts that up to three in four people worldwide will endure that kind of heat by the end of the century, if global warming continues unabated.

“The United States is going to be an oven,” said Camilo Mora of the University of Hawaii, lead author of a study published Monday in the journal Nature Climate Change.

The study comes as much of the U.S. swelters through extended triple-digit heat. Temperatures hit records of 106, 105 and 103 in Santa Rosa, Livermore and San Jose, California on Sunday, as a heat wave was forecast to continue through midweek. In late May, temperatures in Turbat, Pakistan, climbed to about 128 degrees (53.5 degrees Celsius); if confirmed, that could be among the five hottest temperatures reliably measured on Earth, said Jeff Masters, meteorology director of Weather Underground.

Last year 22 countries or territories set or tied records for their hottest temperatures on record, said Masters, who wasn’t part of the study. So far this year, seven have done so.

“This is already bad. We already know it,” Mora said.  “The empirical data suggest it’s getting much worse.”

Mora and colleagues created an interactive global map with past heat waves and computer simulations to determine how much more frequent they will become under different carbon dioxide pollution scenarios. The map shows that under the current pollution projections, the entire eastern United States will have a significant number of killer heat days. Even higher numbers are predicted for the Southeast U.S., much of Central and South America, central Africa, India, Pakistan, much of Asia and Australia.

Mora and outside climate scientists said the study and map underestimate past heat waves in many poorer hot areas where record-keeping is weak. It’s more accurate when it comes to richer areas like the United States and Europe.

If pollution continues as it has, Mora said, by the end of the century the southern United States will have entire summers of what he called lethal heat conditions.

A hotter world doesn’t necessarily mean more deaths in all locales, Mora said. That’s because he found over time the same blistering conditions _ heat and humidity _ killed fewer people than in the past, mostly because of air conditioning and governments doing a better job keeping people from dying in the heat. So while heat kills and temperatures are rising, people are adapting, though mostly in countries that can afford it. And those that can’t afford it are likely to get worse heat in the future.

“This work confirms the alarming projections of increasing hot days over coming decades – hot enough to threaten lives on a very large scale,” said Dr. Howard Frumkin, a University of Washington environmental health professor who wasn’t part of the study.

Mora documented more than 100,000 deaths since 1980, but said there are likely far more because of areas that didn’t have good data. Not all of them were caused by man-made climate change.

Just one heat wave – in Europe in 2003 – killed more than 70,000 people.

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As South Korea Seeks Reconciliation With the North, What’s in it for the US?

As South Korea’s new leadership works toward easing long strained inter-Korean relations, U.S. experts are eyeing the country’s conciliatory overtures to the Kim Jong Un regime, worried that a possible resumption of the Kaesong Industrial Complex could provoke discord with the Trump administration.

Shortly after South Korean President Moon Jae-in named Cho Myoung-gyun to be his North Korea point man on June 13, Cho, who played a key role in launching the now-stalled economic cooperation project, told reporters, “Operations at the Kaesong Industrial Complex should be restored. I will speak after thoroughly looking into the details.” 

That statement caused a flurry of criticism in Washington, with many analysts saying reviving activities at the complex possibly could hurt Washington-Seoul relations and diminish their alliance coordination. Seoul closed the complex in February 2016 as punishment for the regime’s nuclear test and long-range rocket launch.

“Reopening the Kaesong Industrial Complex is very problematic from Washington’s perspective,” Sue Mi Terry, a former CIA analyst who specializes in North Korea, told VOA’s Korean Service.

Launched in 2004 to enhance cooperation between the two Koreas, the jointly run industrial complex in Kaesong, just north of the border, has reportedly provided $100 million a year in wages to 54,000 North Korean workers and contributed almost $2 billion in trade for Pyongyang.

Terry said any conciliatory action that translates into significant financial benefits for Pyongyang contradicts Washington’s North Korea policy, which is focused on thwarting the Kim regime’s nuclear weapons program by severing all possible revenue streams that fund it. 

“We don’t know where the money is going,” Terry said. “It could be contributing to North Korea’s WMD (weapons of mass destruction) missile program. There is no evidence that it’s not.”

Thomas Countryman, who served in the Obama administration as assistant secretary of state for international security and nonproliferation, said restarting Kaesong’s activities would not only reward Kim for the continued provocations, but also throw cold water on international efforts.

“It would be inconsistent with the [U.N. Security Council] resolutions if not in the letter, then in the spirit,” Countryman said. “There is simply no way that [South Korea] could convince China to have a strict enforcement of the U.N. resolutions, if South Korea is reopening a complex that provides tens of millions of dollars of hard currency every year to the North Korean regime.” 

Formerly the Obama White House coordinator for arms control and WMD, Gary Samore of the Belfer Center at Harvard University said Seoul should be more strategic and use Kaesong as a bargaining chip in response to or as part of a deal with Pyongyang to take steps toward limiting and eventually eliminating its nuclear activities.

“It would be a big mistake to resume the Kaesong Industrial Park without getting something in return,” Samore said. “So if Kim Jong Un agrees to some limits on nuclear and missile activity — for example, a freeze on testing — then I think one response that [South Korea] could make would be to resume the Kaesong Industrial Park, with the understanding that the facility would be suspended if Kim Jong Un resumed nuclear and missile testing.”

Negotiations on Pyongyang’s nuclear program have been in limbo for almost a decade, with Washington and Seoul ratcheting up economic pressure and a stubborn Pyongyang persisting with weapons development. But since Moon took office last month, he appears to be easing conditions for talks with the North.

“I make it clear that we will open dialogue without a precondition” should North Korea stop launching missiles and testing nuclear devices, Moon said Thursday at an event marking the 2000 inter-Korean summit.

But when President Donald Trump’s top diplomat Rex Tillerson led a U.N. Security Council special meeting in April, he rejected negotiations with Kim, saying North Korea “must take concrete steps to reduce the threat that its illegal weapons programs pose to the U.S. and our allies before we can even consider talks.” Those steps would be dismantling its nuclear and missile programs.

Moon Chung-in, South Korea’s special presidential advisor for foreign and security affairs, commented at an event in Washington Friday that his president proposed “scaling down” the Washington-Seoul joint military drills if North Korea “suspends its nuclear and missile activities.”

The State Department downplayed the significance of the comments.

“We understand these views are the personal views of Mr. Moon and may not reflect official ROK govern policy,” said Bureau of East Asian and Pacific Affairs spokesperson Alicia Edwards in an email to VOA.

A senior official at the South Korean presidential office said the advisor did not coordinate with the president’s office on the proposal.

This report originated on VOA Korean.

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DC United’s Star Goalie a Muslim Who Balances Faith with Football

Ramadan is Islam’s holy month. It is a time of reflection honoring the first revelation of the Quran to Muhammad. It is also a month of fasting during which able-bodied Muslims abstain from food and drink from sunrise to sunset, which poses unique challenges for professional athletes. VOA’s Arash Arabasadi reports from Washington

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Coroner: Cocaine Among Drugs Found in Carrie Fisher’s System

Carrie Fisher’s autopsy report shows the actress had cocaine in her system when she fell ill on a plane last year, but investigators could not determine what impact the cocaine and other drugs found in her system had on her death.

 

The report released Monday states Fisher may have taken cocaine three days before the Dec. 23 flight on which she became ill. She died four days later.

 

It also found traces of heroin, other opiates and MDMA, which is also known as ecstasy, but that they could not determine when Fisher had taken those drugs. The findings were based on toxicology screenings done on samples taken when the “Star Wars” actress arrived at a Los Angeles hospital.

 

Coroner’s officials ruled Fisher died from sleep apnea and a combination of other factors. A news release issued Friday mentioned drugs were found in Fisher’s system, but it did not provide details.

 

Monday’s full report contains a detailed explanation of the results, such as why investigators believe Fisher took cocaine at least three days before her flight.

 

“At this time the significance of cocaine cannot be established in this case,” the report states.

 

It also states that while heroin is detectable in the system for a briefer period of time, investigators could not determine when Fisher took it or the ecstasy. Toxicology tests also found other opiates in Fisher’s system, including morphine, although the report states the morphine could have been a byproduct of heroin.

 

“Ms. Fisher suffered what appeared to be a cardiac arrest on the airplane accompanied by vomiting and with a history of sleep apnea. Based on the available toxicological information, we cannot establish the significance of the multiple substances that were detected in Ms. Fisher’s blood and tissue, with regard to the cause of death,” the report states.

 

Among the factors that contributed to Fisher’s death was buildup of fatty tissue in the walls of her arteries, the coroner’s office said last week.

 

A phone message left for Fisher’s brother, Todd, was not immediately returned.

 

Todd Fisher said Friday he was not surprised that drugs may have contributed to his sister’s death.

 

“I would tell you, from my perspective that there’s certainly no news that Carrie did drugs,” Todd Fisher said. He noted that his sister wrote extensively about her drug use, and that many of the drugs she took were prescribed by doctors to try to treat her mental health conditions.

 

Fisher long battled drug addiction and mental illness. She said she smoked pot at 13, used LSD by 21 and was diagnosed with bipolar disorder at 24. She was treated with electroshock therapy and medication.

 

“I am not shocked that part of her health was affected by drugs,” Todd Fisher said.

 

He said his sister’s heart condition was probably worsened by her smoking habit, as well as the medications she took.

“If you want to know what killed her, it’s all of it,” he said.

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Tech Titans Gather at White House to Modernize Government

U.S. President Donald Trump on Monday announced he wants to see up to $1 trillion of tax savings over the next decade by a “sweeping transformation of the federal government’s technology.”  

Trump told the American Technology Advisory Council in the White House State Dining Room that “we’re embracing big change, bold thinking and outsider perspectives to transform government and make it the way it should be and at far less cost.”

A slew of high-tech heavyweights, some of whom have criticized President Donald Trump’s policies, huddled at the White House on Monday as the administration kicked off its “technology week.”

The chief executive officers of 18 companies held meetings with White House and other Trump administration officials to generate ideas to attempt to transform and modernize government services.

“In addition to the trillion in cost we can take out, probably we can add another two trillion [dollars] on the numerator in terms of digital business by getting the public and the private sector in full cooperation under your administration,” Bill McDermott, the CEO of enterprise software company SAP, told Trump.  

Also speaking to the group, one of the world’s most successful venture capitalists, John Doerr, contended that there is also a “trillion dollars of value locked up in government databases. The Kleiner Perkins chairman told the president that “if you set the data free the entrepreneurs are going to do the rest.”

Jeff Bezos, the founder of Amazon, the world’s largest online shopping retailer, recommended government, for its transformation, “use commercial technologies whenever possible” to save taxpayers’ money. He also said it was impossible to overstate that investment is needed in machine learning and artificial intelligence.

The CEO of cloud computing company VMware, Pat Gelsinger, echoed that, saying “we deeply believe that we need to be planting those seed corns for our children and grandchildren.”

Microsoft CEO Satya Nadella also agreed, saying increasing competitiveness could be achieved through government spending in research. And the native of India told the president the United States should maintain an “enlightened immigration policy,” noting he was the beneficiary of such a policy.   

The corporate leaders at the table with the president on Monday cumulatively represented more than $3.5 trillion in market value, White House Press Secretary Sean Spicer told reporters.

“Today we’ve assembled a very impressive group of leaders from the private sector and are putting them to work here today to work on some of the country’s biggest challenges that will make a very meaningful difference to a lot of its citizens,” White House senior advisor Jared Kushner said as the White House kicked off the day of meetings.

Kushner, who is President Donald Trump’s son-in-law, says the goal is to “work to modernize the government’s technology infrastructure.”

There is outside skepticism about whether the president’s goal – at least in monetary terms – can be achieved.

“I do not understand how or where that trillion-dollar number comes from,” veteran Silicon Valley engineer Leslie Miley told VOA. “There is no basis for that claim so, as an engineer, I would not believe it until I saw a breakdown.”

The sprawling federal government maintains more than 6,000 data centers, some of the systems stretching back more than a half century.

The Department of Defense is still using floppy disks in some of its computer systems, Kushner noted.

Apple CEO Tim Cook told Trump that computer coding should be a required subject in every public school and that “the U.S. should have the most modern government in the world, and today it doesn’t.”

“Tim Cook is right, we should,” Miley, who has worked at Apple, Google, Slack and Twitter, told VOA. “However, with key leadership positions in the government unfilled, it’s going to be difficult getting a strategy in place and executed.”

Monday’s White House event included working sessions over four hours focused on citizen services, cloud computing, analytics, cybersecurity, big data, purchasing and contract reform, talent recruitment and retraining, government and private sector partnerships, H1-B Visas and future trends, according to a White House official.

Other prominent administration participants included Vice President Mike Pence, National Security Advisor Gen. H.R. McMaster, Homeland Security Advisor Tom Bossert, Office of Management  and Budget Director Mick Mulvaney and three cabinet secretaries: Steven Mnuchin of Treasury, John Kelly of Homeland Security and Wilbur Ross of Commerce.

 

Other participating Silicon Valley chief executives included Eric Schmidt of Alphabet (parent company of Google), Brian Krzanich of Intel, Steven Mollenkopf of Qualcomm, Shantanu Narayen of Adobe and Ginni Rometty of IBM.

Several of those attending on Monday also were at a similar meeting Trump convened last December before his presidential inauguration.

Notably absent from this second meeting was Elon Musk, the chief executive of Tesla and SpaceX, who recently quit as an outside economic advisor to the president in protest of Trump’s decision to withdraw from the Paris Agreement on climate change.

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US Top Court Hands Chevron Victory in Ecuador Pollution Case

The U.S. Supreme Court on Monday handed a victory to Chevron Corp. by preventing Ecuadorean villagers and their American lawyer from trying to collect on an $8.65 billion pollution judgment issued against the oil company by a court in Ecuador.

The justices turned away an appeal by New York-based lawyer Steven Donziger, who has spent more than to two decades trying to hold Chevron responsible for pollution in the Ecuadorean rain forest, of lower court rulings blocking enforcement in the United States of the 2011 judgment.

While not disputing that pollution occurred, San Ramon, California-based Chevron has said it is not liable and that Donziger and his associates orchestrated the writing of a key environmental report and bribed the presiding judge in Ecuador.

U.S. District Judge Lewis Kaplan in Manhattan barred enforcement of the judgment in 2014, citing the corruption used to obtain it. The New York-based 2nd U.S. Circuit Court of Appeals last year upheld Kaplan’s decision, citing “a parade of corrupt actions” by Donziger and his associates, including coercion and fraud, culminating in the bribe offer.

The 2nd Circuit found that Chevron’s $8.646 billion judgment debt was “clearly traceable” to corrupt conduct by the legal team representing the villagers from the area affected by the pollution.

The lengthy legal battle with Chevron has been waged in several countries and was documented in “Crude,” a 2009 documentary film. The plaintiffs have said they plan to continue efforts to enforce the judgment in other countries, regardless of the outcome in the United States.

The saga was drawn extensive media attention over the years, with a succession of reporters given tours by both sides of the affected sites on the edge of the Amazonian jungle near the town of Lago Agrio. The plaintiffs also touted the backing of several celebrities including actors Mia Farrow and Danny Glover.

Donziger and representatives of residents of the Lago Agrio region have sought to force Chevron to pay for water and soil contamination caused from 1964 to 1992 by Texaco, which Chevron acquired in 2001. Chevron has said a 1998 agreement between Texaco and Ecuador absolved it of further liability.

Donziger’s crusade began to unravel when Chevron noticed a deleted scene in the “Crude” documentary, released in 2009, showing Donziger working with supposedly neutral experts in preparing a report for the Ecuadorean court.

Chevron was then able to get access to out-takes and other material related to the documentary via court order. Chevron cited this evidence when it filed its lawsuit in 2011 seeking to block enforcement of the judgment, saying Donziger’s actions violated U.S. anti-racketeering law.

Donziger has also tried to enforce the judgment in Canada, Brazil and other countries where Chevron operates.

 

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US Supreme Court Limits Where Companies Can be Sued

The U.S. Supreme Court on Monday tightened rules on where injury lawsuits may be filed, handing a victory to corporations by undercutting the ability of plaintiffs to bring claims in friendly courts in a case involving litigation over the Bristol-Myers Squibb Co. blood-thinning medication Plavix.

The justices, in an 8-1 ruling, threw out a lower court decision allowing hundreds of out-of-state patients who took Plavix to sue the company in California. State courts cannot hear claims against companies that are not based in the state when the alleged injuries did not occur there, the justices ruled.

The court last month reached a similar conclusion in a separate case involving out-of-state injury claims against Texas-based BNSF Railway Co.

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Google Outlines Steps to Fight Extremist Content

Google says it is stepping up its efforts to identify and remove videos related to terrorism and violent extremist content, particularly on its YouTube platform.

“While we and others have worked for years to identify and remove content that violates our policies,” Google said, “the uncomfortable truth is that we, as an industry, must acknowledge that more needs to be done. Now.”

First, the company says it’s increasing its use of technology to identify videos that contain extremist messages. It added that it has used “video analysis models” to find and assess more than 50 percent of the terrorism-related content that has been removed in the past six months.

“We will now devote more engineering resources to apply our most advanced machine learning research to train new ‘content classifiers’ to help us more quickly identify and remove extremist and terrorism-related content,” the company said.

The company acknowledges that technology can’t fully solve the problem, so it is also adding 50 expert NGO’s to its YouTube Trusted Flagger program. Flaggers, the company said, can better identify the difference between violent propaganda and news and that they are more than 90 percent accurate. Google says it already works with 63 organizations as part of the program.

Google said it will also be taking a “tougher stance on videos that do not clearly violate our policies.” It said videos that “contain inflammatory religious or supremacists content” will appear with a warning. People will not be able to make money off them, or to comment on or endorse them.

“That means these videos will have less engagement and be harder to find,” Google wrote. “We think this strikes the right balance between free expression and access to information without promoting extremely offensive viewpoints.”

In a fourth step, Google said it will “expand its role in counter-radicalization efforts” through what it calls the “Redirect Method.”

“This promising approach harnesses the power of targeted online advertising to reach potential Isis recruits and redirects them towards anti-terrorist videos that can change their minds about joining,” Google wrote, in reference to Islamic State. “In previous deployments of this system, potential recruits have clicked through on the ads at an unusually high rate, and watched over half a million minutes of video content that debunks terrorist recruiting messages.”

The steps were first published in an opinion piece Sunday on the Financial Times website and can now be found on a Google blog.

Google’s steps follow a recent Facebook announcement that the social media giant is using artificial intelligence to combat terrorist content.

Earlier this year, the non-profit Southern Poverty Law Center issued a report critical of organizations like Google and Facebook. The anti-hate group said the companies “have done little to counter the use of their platforms to spread hateful, false “information,” from conspiracy theories accusing various minority groups of plotting against America to websites promoting Holocaust denial and false “facts” about Islam, LGBT people, women, Mexicans and others.”

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BRICS Meeting Highlights Climate Change, Trade, Terrorism

Climate change, trade and terrorism were highlighted Monday at a Beijing meeting of foreign affairs officials from Brazil, Russia, India, China and South Africa, known collectively as the BRICS nations.

The five nations are seeking to further align their views on key issues at a time when President Donald Trump is withdrawing the U.S. from multilateral arrangements such as the Paris climate accords and the Trans-Pacific Partnership trade deal.

Chinese Foreign Minister Wang Yi said China in the coming year would look to “expand with more broad and wide-ranging cooperation in areas such as trade and commerce and investment.”

Together the BRICS countries account for roughly 40 percent of the world population and 20 percent of the global economy. All five countries are members of the G20, although their economic prospects have declined somewhat amid crises in Brazil and South Africa and the effect of sanctions lodged against Russia by the West.

South African Foreign Minister Maite Nkoana-Mashabane pointed to climate change as a major concern.

“There is one climate and for future generations we must employ every effort at our disposal to reverse the effects of climate change,” she said.

Nkoana-Mashabane also pointed to the need to form joint efforts to fight terrorism, sentiments reflected by Vijay Kumar Singh, an Indian External Affairs official.

“It is important to enhance BRICS security in counterterrorism matters,” Singh said.

Leaders of the five nations are due to meet for a summit in the southeastern Chinese city of Xiamen in September.

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Little-known Koepka Wins US Open Golf Championship

Little-known American golfer Brooks Koepka won the 117th U.S. Open championship Sunday for his first major title at the age of 27. He’d only won one previous tournament on the PGA Tour.

Koepka tied for the best score in relation to par in the history of the U.S. Open with a 16-under 272 for the four rounds on the par 72 course. His margin of victory was four shots over two golfers who tied for second place — Brian Harman, also from the U.S., and Japan’s Hideki Matsuyama.

“It’s definitely a special moment,” Koepka said shortly after completing his final round of 5-under-par 67. “The way I putted this week was unbelievable. . . What I’ve done this week is amazing.”

Koepka pulled away on the closing holes by making a difficult save of par on the 13th hole, then sinking birdie putts on the 14th, 15th and 16th holes.

The Florida native said he received lots of encouragement and advice from friends and family Saturday night, ahead of the final round, and that he felt very confident in his game. And he said he knew where he stood throughout the final round because there were very clear leader boards at each hole.

“I just tried to get as low as I could (on each hole) and stay focused,” Koepka said.

This year’s tournament was played at Erin Hills, an 11-year-old course less than an hour’s drive from Milwaukee, Wisconsin. A U.S. Open had never been held in that north central state before.

While more players than usual broke par at a U.S. Open, many of the world’s best golfers failed to make the halfway cut after Friday’s second round. In fact, it was the first time since the world rankings were created in 1986 that the top three ranked golfers in the world missed the cut.

They are defending champion and world No. 1 Dustin Johnson of the United States, No. 2 Rory McIlroy of Northern Ireland and No. 3 Jason Day of Australia. It was McIlroy who also shot 16-under-par in winning his U.S. Open title at Congressional Country Club outside Washington in 2011.

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Hundreds of Thousands Gather at Brazil Gay Parade

Hundreds of thousands of people are gathering in the Brazilian city of Sao Paulo for one of the world’s largest gay pride parades.

 

The revelers have packed the city’s Paulista Avenue before Sunday’s parade. Some are helping hold up a gigantic rainbow-colored flag symbolizing LGBT rights.

 

Organizers say they expect 3 million people to participate in the city’s 21st annual gay pride parade.

The parade this year focuses on secularism and the idea that no religion is law regardless of people’s individual beliefs.

 

Claudia Regina is president of the gay rights group organizing the parade.

 

She says on the event’s official Facebook page that “our main enemies today are religious fundamentalists” and says some groups insist on condemning LGBT people and “removing rights that we have already obtained.”

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With Whole Foods, Amazon on Collision Course With Wal-Mart

When Wal-Mart Stores Inc. bought online retailer Jet.com for $3 billion last year, it marked a crucial moment — the world’s largest brick-and-mortar retailer, after years of ceding e-commerce leadership to arch rival Amazon, intended to compete.

On Friday, Amazon.com Inc. countered. With its $14 billion purchase of grocery chain Whole Foods Market Inc., the largest e-commerce company announced its intention to take on Wal-Mart in the brick-and-mortar world.

The two deals make it clear that the lines that divided traditional retail from e-commerce are disappearing and sector dominance will no longer be bound by e-commerce or brick-and-mortar,  but by who is better at both.

Amazon’s purchase of Whole Foods also brings disruption to the $700 billion U.S. grocery sector, a traditional area of retailing that stands on the precipice of a ferocious price war.

German discounters Aldi and Lidl are battling Wal-Mart, which controls 22 percent of the U.S. grocery market, with each vowing to undercut whatever price the others offer.

The stakes are highest for Wal-Mart. Amazon’s move aims at the heart of the Bentonville, Arkansas-based retail giant’s business — groceries, which account for 56 percent of Wal-Mart’s $486 billion in revenue for the year ending Jan. 31. With the deal, Whole Foods’ more than 460 stores become a test bed with which Amazon can learn how to compete with Wal-Mart’s 4,700 stores with a large grocery offering that are also within 10 miles (16 km) of 90 percent of the U.S. population.

Amazon is expected to lower Whole Foods’ notoriously high prices, enabling it to pursue Wal-Mart’s customers. The push comes as Wal-Mart is headed in the opposite direction — going

after Amazon’s higher-income shoppers with a recent string of acquisitions of online brands such as Moosejaw and Modcloth and on Friday, menswear e-tailer Bonobos.

Wal-Mart may be ready. In preparation for the grocery price war, Wal-Mart in recent months has cut grocery prices, improved fresh food and meat offerings, modernized shelving and lighting

in its grocery aisles, and expanded its online grocery pickup service.

Marc Lore, the Jet.com founder who now runs Wal-Mart’s e-commerce business after selling a startup to Amazon, told Reuters in an interview that Amazon’s move does not change Wal-Mart’s game plan. “We’re playing offense,” he said.

Wal-Mart is offering curbside pickup of online grocery purchases at 700 locations, with 300 more planned by year end.

It also is testing same-day fresh and frozen home delivery from 10 of its stores. “We see an opportunity to do a lot more of that,” Lore said.

Roger Davidson, who oversaw Wal-Mart’s global food procurement and now is president of Oakton Advisory Group, said the deal will reduce Wal-Mart’s brick-and-mortar advantage.

“I think this acquisition is a concern,” he said.

Some industry observers say Amazon will find it difficult to use Whole Foods to pull away Wal-Mart shoppers because the two stores appeal to different customers. But Michelle Grant, head of retailing at market research firm Euromonitor, said Amazon could use an obscure part of the Whole Foods portfolio — Whole Foods 365 — to lure Wal-Mart shoppers.

Whole Foods 365 offers private-label goods and lower prices than typical Whole Foods stores, and is targeted at younger, value-conscious shoppers. Amazon could provide the financial

capital and tactical ability to build that into something big.

“That [Whole Foods 365] may become a big problem for Wal-Mart,” Grant said.

Amazon, which reported $12.5 billion in cash and equivalents and a free cash flow of $10.2 billion in the year ended March 31, has plenty to spend. Wal-Mart reported $6.9 billion in cash

and equivalents and $20.9 billion in free cash flow at its year ended Jan. 31.

Brittain Ladd, a former senior manager at Amazon who worked on its brick-and-mortar strategy, said Amazon will use Whole Foods to test concepts for the grocery store of the future.

Ladd, who left Amazon in March, said Amazon will seek to eliminate checkout lines by using technology that automatically scans goods as customers add them to their shopping carts. It

will select merchandise based on Amazon’s vaunted customer data, and potentially expects the use of technology to change prices during the course of a day.

Amazon declined comment on competition with Walmart but spokesman Drew Herdener said in a statement the company has no plans to cut jobs or use technology in development at its

Seattle Amazon Go store to automate jobs of cashiers.

Ladd, who helped with AmazonFresh’s global expansion and now is a supply chain consultant, said an Amazon-owned Whole Foods also likely will offer in-car pickup of online purchases, and

home delivery from Whole Foods stores, add pharmacies and showcase Amazon devices inside the stores.

“Amazon will reduce prices and change the assortment of products carried in Whole Foods stores to attract a larger customer base,” said Ladd. “Kroger and Wal-Mart will be impacted as their customers will defect to Amazon.”

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Reports: Beyonce Gives Birth to Twins in L.A.

U.S. singer Beyonce has given birth to twins in Los Angeles, several celebrity news websites reported Saturday, citing unidentified sources.

Beyonce, 35, and rapper and music producer Jay Z, also have a 5-year-old daughter, Blue Ivy.

E! News, citing multiple unidentified sources, reported the birth and that Jay Z and Blue Ivy were seen at a Los Angeles area hospital Thursday. Us Weekly, also citing multiple unidentified sources, reported that the couple welcomed twins earlier this week.

“Bey and Jay are thrilled and have started sharing the news with their family and closest friends,” one unidentified source told PEOPLE.

Reuters could not verify the reports. A representative for Beyonce did not respond immediately to a request for comment.

The celebrity news websites did not provide additional details, such as the date and time the twins were born or the sex of the infants.

Pregnancy announced on Instagram

The “Lemonade” singer, one of the most powerful women in the music business, announced the pregnancy on her Instagram account in February along with an image of her posed in lingerie and caressing a noticeable baby bump.

The announcement got more than 8 million “likes” in the first 24 hours to become the “most-liked” Instagram ever.

The R&B singer performed live at the Grammy awards in Los Angeles two weeks later, proudly displaying her swelling belly in a motherhood-themed show. She has since posted numerous pictures of her bare baby bump on her social media accounts.

The birth of Blue Ivy caused a paparazzi storm in 2012, with New York’s Lenox Hill hospital shutting down part of its maternity wing to accommodate music’s royal couple.

Rumor of marital trouble

News of the pregnancy came less than a year after the release of Beyonce’s 2016 album “Lemonade,” in which she appeared to address long-standing rumors of trouble in her eight-year marriage.

The lyrics of several songs spoke about being cheated on, and regretting being married. But Beyonce made clear in the final tracks of the album and in music videos featuring Jay-Z that she had decided to stay in the relationship.

The couple have never addressed the rumors publicly.

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3-D-Printed Architecture Looks to the Past for Inspiration

The soaring cathedrals of Europe seem to defy gravity. But 3-D architects are taking a page from the ancient masters to form their new creations. VOA’s Kevin Enochs reports.

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3D Printed Architecture Looks to the Past for Inspiration

The soaring cathedrals of Europe seem to defy gravity. But 3D architects are taking a page from the ancient masters to form their new creations. VOA’s Kevin Enochs reports.

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Stephen Furst, of ‘Animal House’ and ‘St. Elsewhere,’ Dies at 63

Stephen Furst, who played naive fraternity pledge Flounder in the hit movie Animal House, has died of complications from diabetes, his family said Saturday. Furst was 63.

Furst died Friday at his home in Moorpark, California, north of Los Angeles, said his son, Nathan Furst.

Furst played Kent “Flounder” Dorfman in the 1978 film that also starred John Belushi. It was Belushi’s character, Blutarsky, who drew Flounder into a prank that went terribly wrong and ended up with the frantic Flounder shooting a horse.

Furst’s long list of credits included the 1980s medical drama St. Elsewhere, on which he played Dr. Elliot Axelrod. He played Vir Coto and was an occasional director on the 1990s sci-fi series Babylon 5.

He also voiced characters on projects including TV’s Buzz Lightyear of Star Command and the video The Little Mermaid 2: Return to the Sea.

“He was proudest of his family, and he felt blessed and incredibly privileged to have the career that he had an enjoyed,” Nathan Furst said Saturday.

Stephen Furst also was a director and producer, working with his other son, Griff. Their Curmudgeon Film projects included the movies My Sister’s Keeper and Cold Moon, a suspense thriller set for release in October, Griff Furst said.

Stephen Furst’s survivors include his wife, Lorraine, and two grandchildren, his sons said.

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Tax Overhaul in Trouble as Opposition to Import Tax Grows

A key part of House Republicans’ plan to overhaul the way corporations pay taxes is on life support, leaving lawmakers scrambling to save one of President Donald Trump’s biggest priorities and increasing the chances the GOP will simply pass a tax cut instead of overhauling the tax code.

A proposed tax on imports is central to the GOP plan to lower the overall corporate tax rate. It would generate about $1 trillion over the next decade to finance the lower rates without adding to the deficit. It would also provide strong incentives for U.S.-based companies to keep their operations in the United States and perhaps persuade companies to move overseas operations to the U.S.

But the tax faces strong opposition from retailers, automakers and the oil industry, and a growing number of congressional Republicans have come out against it. They worry that it will increase the cost of imports, raising consumer prices.

Import tax

Majority Leader Mitch McConnell, R-Ky., says there probably aren’t enough votes to pass the import tax in the Senate — not a single Republican senator has publicly endorsed it. And a powerful group of House conservatives says it’s time to dump the idea.

“The sooner we acknowledge that and get on with a plan that actually works and actually can build consensus, the better off we will be,” said Rep. Mark Meadows, R-N.C., chairman of the conservative Freedom Caucus.

Even one of the biggest backers of the new tax says he is open to other ideas.

Rep. Kevin Brady, R-Texas, has pushed the tax as chairman of the powerful House Ways and Means Committee. He still says it’s the best way to promote economic growth and domestic jobs, but he has softened his stance on alternatives.

“I’m still confident that we’re going to stay at the table until we solve that problem, which is how do we stop U.S. jobs from continuing to leave the United States,” Brady said. “We’re going to remain open to the best ideas on how we do that.”

On Tuesday, Brady proposed gradually phasing in the tax over five years to give corporations time to adjust.

It wasn’t received well by opponents.

“Forcing consumers to pay more so that some profitable companies can operate tax-free is no better of an idea in five years than it is today,” said Brian Dodge of the Retail Industry Leaders Association.

What next?

But if the import tax is dead, then what?

“I would never declare anything dead until there was a fully formed alternative,” said Rohit Kumar, a former tax counsel to McConnell who now heads PwC’s Washington tax office. “I think that’s one of the big challenges that Republicans are struggling with right now.”

Thirty-one years after the last tax overhaul, there is widespread agreement that the current system is too complicated and picks winners and losers, compelling companies to make decisions based on tax implications instead of sound business reasons.

The goal — for now — is to simplify the tax code and make it more efficient in a way that does not add to the federal government’s mounting debt. That means some would pay more and some would pay less, a heavy political lift among politicians who have deep political and practical disagreements.

Lawmakers also are trying to overhaul taxes on individuals, which raises another set of big challenges.

“It’s easier to get a coalition to cut taxes,” said Mark Mazur, a former Treasury official under President Barack Obama. “And if the conversation is, `how long do they last and how deep are the tax cuts,’ each party knows how to do that conversation. It’s not like you’re asking for a huge lift.”

The new import tax, which is called a border adjustment tax, would radically change the way corporations are taxed. Under current law, corporations pay a top tax rate of 35 percent on their profits. But the tax code is filled with so many exemptions, deductions and credits that most corporations pay a much lower rate.

Proposal

Under the proposed system, American companies that produce and sell their products in the U.S. would pay a new 20 percent tax on the profits from these sales. However, if a company exports a product, the profits from that sale would not be taxed by the U.S.

Foreign companies that import goods to the U.S. would also have to pay the tax, and they would not be able to deduct the cost of the imported good as a business expense.

Republicans in Congress and at the White House have been meeting behind closed doors for weeks to come up with viable alternatives. Democrats have been largely excluded from the talks, leaving Republicans with little room for error.

“I still think that Republicans, out of pure political necessity, if nothing else, are likely to find a way to get some sort of tax bill to the president’s desk for his signature,” Kumar said.

Whether it’s genuine tax reform or simply a tax cut “is still very much in question right now,” he added.

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Judge Declares Mistrial in Cosby Rape Trial

A United States judge has declared a mistrial in the sexual assault trial of celebrity comedian Bill Cosby after jurors could not reach a unanimous decision about Cosby’s guilt.

The jury deadlocked after more than 50 hours of deliberation in Norristown, Pennsylvania, over charges that he drugged and then molested a woman in 2004.

WATCH: Cosby defense team on jurors

Prosecutors said immediately that they would retry the Cosby Show star, and he remains charged with three counts of aggravated indecent assault.

The jury seemed exasperated at times over the course of the week as it repeatedly asked the judge for clarifications of evidence or to hear testimony from the trial again.

Jury couldn’t reach unanimous decision

On Thursday, the fourth day of deliberation, jurors told Judge Steven O’Neill they were deadlocked, but he instructed them to keep working to try and reach a unanimous decision.

On Saturday, after they reported to O’Neill they were at an impasse and would not be able to reach a consensus, he was forced to call a mistrial.

​The 79-year-old Cosby is charged with drugging and assaulting Andrea Constand, a former director of operations of the Temple University women’s basketball team.

He allegedly gave her pills that paralyzed her and left her unable to resist when he started touching her in his Philadelphia home.

Faced life in prison

If found guilty, Cosby could go to prison for the rest of his life.

More than 50 women claim Cosby sexually assaulted them in incidents dating back to the 1960s, when he emerged as a major comedy star. Most of the alleged incidents occurred too long ago to be prosecuted now.

Constand’s complaint is the only one that has come to trial. Cosby has denied all the charges.

WATCH: Prosecutors say they’ll retry case

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