A landmark deal to allow grain exports from Ukraine, which was back on track Wednesday after being briefly suspended, has played a crucial role in easing a global food crisis sparked by the Russian invasion of Ukraine.

Brokered by the United Nations and Turkey and signed by Moscow and Kyiv on July 22, the agreement established a protected sea corridor to allow grain shipments to resume for the first time since the fighting began in February

Here is what we know about the deal, known as the Black Sea Grain Initiative:

Why was it needed?

When Russian troops attacked in late February, Moscow imposed a blockade on Ukraine’s Black Sea ports, halting all agricultural exports from one of the world’s breadbaskets.

The move left 20 million metric tons of grain stranded in Ukraine’s ports, causing food prices to surge worldwide.

Before the war, up to 90% of Ukraine’s wheat, corn and sunflower exports were transported by sea, mostly from Odesa, with many developing countries relying heavily on Kyiv for grain.

Agricultural commodity prices were high before the war because of the post-COVID-19 economic recovery, but the conflict pushed the price of grains such as wheat and corn to levels unsustainable for countries dependent on their import, such as Egypt, Lebanon and Tunisia.

What does the deal cover?

The deal ensures the safe export of grain, foodstuffs and fertilizers, including ammonia, from three Black Sea ports in southwestern Ukraine: Odesa, Chornomorsk and Pivdennyi.

The first grain ship to leave under the U.N.-backed deal set sail on August 1.

According to U.N. figures as of November 1, a total of 9.7 million metric tons of grain and other agricultural products have been transported in the first three months of the initiative, the vast majority involving wheat and corn.

Valid for 120 days, the agreement is up for renewal on November 19 in a process that can be done automatically without further negotiations.

The U.N. says extending the deal is crucial for global food security and is pushing for it to be renewed for one year.

Although the initiative is working well, shipments are about 40-50% lower than what they were before Russia’s invasion, the U.N. says.

How does it work?

According to the U.N.’s website, the agreement establishes a safe corridor between the three Ukrainian ports and an area in Turkish waters where the vessels are inspected before being allowed to continue their journey.

To monitor the agreement, a joint command and control center was set up in Istanbul to oversee smooth operations and resolve disputes.

Known as the Joint Coordination Center (JCC), the JCC has four teams of eight inspectors — two each from Russia, Ukraine, Turkey and the U.N.

These teams inspect outbound vessels carrying grain at the Turkish inspection area to ensure all merchandise is approved.

The teams also examine empty ships returning to Ukraine to ensure they are not carrying any weapons or other unauthorized goods or people.

Safe passage

The deal establishes a buffer zone of 10 nautical miles around each vessel traveling along the corridor with no military ships, equipment or drones allowed within that radius.

All ship movements logged by the JCC are transmitted to the relevant military authorities to prevent any incidents, with any violations or threats to be handled by the JCC.

At the start of the war, Ukraine mined its main Black Sea ports to head off threats of a Russian attack from the sea, but experts said it would take too long to de-mine all these areas.

The deal allows Ukrainians to guide the ships along safe routes that avoid known mine fields and into and out of its territorial waters.

Deal briefly suspended

On October 29, Russia said it was suspending its participation in the deal, accusing Ukraine of using the shipping corridor to launch a drone attack on its Black Sea fleet in Crimea’s Sevastopol port.

After a call between the Russian and Turkish defense ministers, the deal resumed operation at 0900 GMT on November 2 with Moscow saying it had received written guarantees from Kyiv ensuring the corridor would not be used for attacking Russian forces.
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Europe has warmed more than twice as much as the rest of the world over the past three decades and has experienced the greatest temperature increase of any continent, according to a report by the World Meteorological Organization. 

The report on the state of the climate in Europe follows a summer of extremes. A record-breaking heat wave scorched Britain, Alpine glaciers vanished at an unprecedented rate and a long-lasting marine heat wave cooked the waters of the Mediterranean.  

“Europe presents a live picture of a warming world and reminds us that even well-prepared societies are not safe from impacts of extreme weather events,” WMO secretary-general Petteri Taalas said in a statement.  

From 1991 to 2021, temperatures over Europe warmed at an average of 0.5 degree Celsius per decade, the report said, while the global average was just 0.2 degree C. 

Last year, extreme weather events made worse by climate change — chiefly floods and storms — caused more than $50 billion worth of damage in Europe. 

The reason Europe is warming faster than other continents has to do with the fact that a large part of the continent is in the sub-Arctic and Arctic — the fastest-warming region on Earth — as well as changes in climate feedbacks, scientists said. 

For example, fewer clouds over Europe during the summer has meant that more sunlight and heat now reaches the continent, said Freja Vamborg, senior scientist with the Copernicus Climate Change Service. 

Some scientists have called Europe a “heat wave hot spot” as the number of heat waves on the continent has increased faster than in other regions because of changes in atmospheric circulation.  

Although temperatures are rising, the European Union has cut greenhouse gas emissions by 31% between 1990 and 2020, the report said, and it aims to slash emissions by 55% by 2030.  

On November 6, delegates will arrive in Egypt for COP27, the annual U.N. climate summit. 

French President Emmanuel Macron and European Commission President Ursula von der Leyen are expected to attend. British Prime Minister Rishi Sunak’s decision not to attend the COP27 climate summit is being kept under review, his spokesman said Monday.
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The World Health Organization warned Wednesday that Ebola’s arrival in the Ugandan capital highlighted the high risk of further spread of the deadly virus, calling on neighboring countries to boost their preparedness. 

Since Uganda’s health ministry first declared the outbreak on September 20, the country has registered more than 150 confirmed and probable cases, including 64 deaths, WHO said. 

And since the deadly disease spread to Kampala last week, 17 cases have been confirmed there, WHO chief Tedros Adhanom Ghebreyesus told reporters. 

“Although these cases are linked to known clusters, the very fact that there are cases in a densely populated city underscores the very real risk of further transmission,” he said, speaking from WHO headquarters in Geneva. 

There is a “very urgent need for increased readiness in districts and surrounding countries,” he warned. 

Ebola is spread through bodily fluids, with common symptoms being fever, vomiting, bleeding and diarrhea. It is fought through tracing, containing and quarantining.

Outbreaks are difficult to contain, especially in urban environments. 

“Ebola in a complex, urban city like Kampala is not easy, and we have to do everything possible to pull every chain of transmission,” WHO incident manager Abdi Mahamud told reporters. 

Tedros said the U.N. health agency had on Tuesday released an additional $5.7 million from its contingency fund for emergencies, in addition to the $5 million previously released to address the Uganda crisis. 

WHO, he said, was working closely with the Ugandan government and partners to respond to the outbreak and was calling for “a strengthened global response and increased donor investment.”  

Uganda’s last recorded fatality from a previous Ebola outbreak was in 2019. 

The strain now circulating in Uganda is known as the Sudan Ebola virus, for which there is currently no vaccine, although there are several candidate vaccines heading toward clinical trials. 
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Ahead of the COP27 climate talks in the Egyptian resort of Sharm el-Sheikh next week, there are concerns that Russia’s invasion of Ukraine has reversed progress on tackling climate change. But as Henry Ridgwell reports, some say the war could have a positive impact in the longer term
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Three of the largest U.S. pharmacy chains — CVS, Walgreens and Walmart — are reported to have tentatively agreed to pay more than $13 billion to settle more than 3,000 state and local lawsuits involving the dispensing of opioid painkillers. 

Sources close to the negotiations report CVS will pay $5 billion over 10 years, Walgreens will pay $5.7 billion over 15 years and Walmart will pay $3.1 billion, mostly up front. The sources remained anonymous as they were not authorized to speak publicly about the agreement. 

 

In a statement released Wednesday, CVS Health said it has agreed it will pay approximately $5 billion — with $4.9 billion to states and political subdivisions and approximately $130 million to Native American tribes — over the next 10 years beginning in 2023. 

In the statement, CVS Health Chief Policy Officer and General Counsel Thomas Moriarty said, “We are committed to working with states, municipalities and tribes, and will continue our own important initiatives to help reduce the illegitimate use of prescription opioids.”  

The CVS statement included a list of initiatives it has undertaken to fight opioid abuse.  

In the lawsuits, governments said pharmacies were filling prescriptions they should have flagged as inappropriate. 

If the settlement is finalized, it would be the first nationwide deal with retail pharmacy companies and follows nationwide opioid settlements with drugmakers and distributors totaling more than $33 billion. 

Opioids are natural, synthetic, or semi-synthetic chemicals used to reduce the intensity of pain signals and feelings of pain. The class of drugs includes the illegal drug heroin, synthetic opioids such as fentanyl, and pain medications available legally by prescription, such as oxycodone, hydrocodone, codeine, morphine, and many others. 

The U.S. Centers for Disease Control and Prevention reports that from 1999 to 2020, more than 564,000 people in the U.S. died from an overdose involving an opioid, including prescription and illicit opioids. They report 187 people in the U.S. continue to die from an opioid overdose every day. 

The Associated Press and Reuters provided some information for this report. 

 
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New research shows vaccinating pregnant women helped protect their newborns from the common but scary respiratory virus called RSV that fills hospitals with wheezing babies each fall.

The preliminary results buoy hope that after decades of failure and frustration, vaccines against RSV may finally be getting close.

Pfizer announced Tuesday that a large international study found that vaccinating moms-to-be was nearly 82% effective at preventing severe cases of RSV in their babies’ most vulnerable first 90 days of life. At age 6 months, the vaccine still was proving 69% effective against serious illness — and there were no signs of safety problems in mothers or babies.

“Moms are always giving their antibodies to their baby,” said virologist Kena Swanson, Pfizer’s vice president of viral vaccines. “The vaccine just puts them in that much better position” to form and pass on RSV-fighting antibodies.

The vaccine quest isn’t just to protect infants. RSV is dangerous for older adults, too, and both Pfizer and rival GSK recently announced that their competing shots also proved protective for seniors.

None of the findings will help this year when an early RSV surge already is crowding children’s hospitals. But they raise the prospect that one or more vaccines might become available before next fall’s RSV season.

“My fingers are crossed,” said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University. “We’re making inroads.”

Tuesday’s data was reported in a press release and hasn’t been vetted by independent experts.

Here’s a look at the long quest for RSV vaccines.

What is RSV?

For most healthy people, RSV, or respiratory syncytial virus, is a cold-like nuisance. But for the very young, the elderly and people with certain health problems, it can be serious, even life-threatening. The virus can infect deep in the lungs, causing pneumonia, and in babies, it can impede breathing by inflaming tiny airways.

In the U.S., about 58,000 children younger than 5 are hospitalized for RSV each year, and several hundred die. Among adults 65 and older, about 177,000 are hospitalized with RSV and 14,000 die annually.

Worldwide, RSV kills about 100,000 children a year, mostly in poor countries.

Why is there no vaccine?

A tragedy in the 1960s set back the whole field. Using the approach that led to the first polio vaccine, scientists made an experimental RSV vaccine by growing the virus in a lab and killing it. But testing in children found not only was the vaccine not protective, youngsters who caught RSV after vaccination fared worse. Two died.

“For a period of 20 years, even though science was advancing, nobody wanted to go near development of an RSV vaccine,” Schaffner said.

Even today’s modern RSV vaccine candidates were tested first in older adults, not children, he noted.

How did development get back on track?

Modern vaccines tend to target the outer surface of a virus — what the immune system sees when a germ invades. For RSV, that target is the so-called F protein that helps the virus latch onto human cells. Again, there was a hurdle: That protein is a shape-shifter, rearranging its form before and after it “fuses” to cells.

It turns out that the immune system only forms effective RSV-fighting antibodies when it spots what’s called the pre-fusion version of that protein, explained structural biologist Jason McLellan of the University of Texas at Austin.

In 2013, McLellan and virologist Barney Graham were working at the National Institutes of Health when they homed in on the correct shape and figured out how to freeze it in that form. That finding opened the way to today’s development of a variety of experimental RSV vaccine candidates.

(That same discovery was key to the hugely successful COVID-19 vaccines, as the coronavirus also is cloaked in a shape-shifting surface protein.)

What’s in the pipeline?

Several companies are creating RSV vaccines, but Pfizer and GSK are furthest along. Both companies recently reported final-stage testing in older adults. The competing vaccines are made somewhat differently but each proved strongly effective, especially against serious disease. Both companies plan to seek regulatory approval in the U.S. by the end of the year, as well as in other countries.

The older-adult data “looks fantastic,” said McLellan, who has closely followed the vaccine development. “I think we’re on the right track.”

And if vaccinating pregnant women pans out, it could be “a win for two individuals instead of just one,” by offering protection to both mom-to-be and baby, said Dr. Wilbur Chen of the University of Maryland School of Medicine.

Pfizer’s maternal vaccine is the same recipe that it tested successfully in older adults — and it also plans to seek Food and Drug Administration approval for those vaccinations by year’s end.

The new study included 7,400 pregnant women in 18 countries, including the U.S., and spanned multiple RSV seasons. Preliminary results reported Tuesday show the vaccine was most effective against severe disease. For milder illness, effectiveness was 51% to 57% — short of the study’s statistical requirements but a result that Pfizer still called clinically meaningful because it could mean fewer trips to the doctor’s office.
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Lebanon received a first batch of vaccines Monday to combat a worsening cholera outbreak – together with sharply worded criticism of its crumbling public health infrastructure from France, which facilitated the donation of the doses.

By Sunday, cases of cholera – a disease typically spread through contaminated water, food or sewage – stood at 1,447, with 17 deaths, since the first were recorded in the country a month ago, Lebanon’s health ministry said.

Lebanon had been cholera-free since 1993, but its public services are suffering under a brutal economic crisis now in its fourth year, while infighting among the country’s faction-riven elite has paralyzed its political institutions.

The outbreak has reached Beirut, but authorities say most cases remain concentrated where it started in the northern town of Bebnine, where health authorities have set up an emergency field hospital.

The vaccines would play “an essential role” in limiting the disease’s spread, Health Minister Firass Abiad told reporters in the capital as he announced the first batch.

Standing next to Abiad, French ambassador Anne Grillo said the delivery comprised more than 13,000 doses. They had been donated by the philanthropic arm of French health care company Sanofi and the French government had facilitated their arrival to Lebanon.

“The origins of this epidemic, in which public health is at stake, must also be treated,” Grillo told reporters. The outbreak was “a new and worrying illustration of the critical decline in public provision of access to water and sanitary services in Lebanon.”

In the Bebnine field hospital, two young boys sat next to each other on one hospital bed, while a mother waited anxiously to confirm if her son, lying limp on another bed and being treated by a doctor and a nurse, had also caught the disease.

Nearby, Syrian children in a makeshift refugee camp played in dirty water chocked with rubbish and medical waste and fed by an outflow from an open pipe.

The World Health Organization has linked cholera’s comeback in Lebanon to an outbreak in neighboring Syria, to where it had spread from Afghanistan via Iran and Iraq.
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On Tuesday, Nov. 1, Australia’s most populous state is banning a range of single-use plastic, including straws, cutlery and bowls.

Polystyrene foam food containers are also banned under the new rules in New South Wales, along with some face, body and hair products that contain plastic micro beads.   

Businesses that breach the regulations could face fines of tens of thousands of dollars.  

Minister for Environment and Heritage James Griffin said in a statement in September that the ban was just the start of a “massive shift away from single-use plastic.”  

He has predicted the ban would stop 2.7 billion items of plastic ending up as litter over the next 20 years. 

The laws in New South Wales are part of a nationwide push to curb waste. State authorities in Queensland and Victoria will bring in similar bans next year.  

Environmental campaigners have welcomed the laws but insist much more needs to be done. Australia currently recycles 16% of its plastic packaging, below the national target of 70%.   

Shane Cucow of the Australian Marine Conservation Society told VOA that recycling needs to be improved, because “Every wrap, pack and snack at a supermarket these days is covered in plastic.”

He added that, “We can get rid of some of those single-use plastics that are highly littered and regularly ending up in our oceans like cups and straws and take-away containers and plastic bags, and that is really important, but at the same time there is just so much plastic packaging on everything that is not able to be recycled properly and so it has got nowhere to go except being buried in landfill or washing out into our oceans.”

In June, New South Wales also banned lightweight plastic bags.
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Research in Africa found a one-time dose of an experimental drug protected adults against malaria for at least six months, the latest approach in the fight against the mosquito-borne disease. 

Malaria killed more than 620,000 people in 2020 and sickened 241 million, mainly children under 5 in Africa. The World Health Organization is rolling out the first authorized malaria vaccine for children, but it is about 30% effective and requires four doses. 

The new study tested a very different approach — giving people a big dose of lab-made malaria-fighting antibodies instead of depending on the immune system to make enough of those same infection-blockers after vaccination.

“The available vaccine doesn’t protect enough people,” said Dr. Kassoum Kayentao of the University of Sciences, Techniques and Technologies in Bamako, Mali, who helped lead the study in the villages of Kalifabougou and Torodo. 

In those villages during malaria season, other research has shown, people are bitten by infected mosquitoes on average twice a day. 

The experimental antibody, developed by researchers at the U.S. National Institutes of Health, was given by IV — difficult to deliver on a large scale. But the encouraging findings bode well for an easier-to-administer shot version from the same scientists that’s in early testing in infants, children and adults.

The U.S. government research was published Monday in the New England Journal of Medicine and presented at a medical meeting in Seattle. 

The antibody works by breaking the life cycle of the parasite, which is spread through mosquito bites. It targets immature parasites before they enter the liver where they can mature and multiply. It was developed from an antibody taken from a volunteer who received a malaria vaccine. 

The research involved 330 adults in Mali who got either one of two different antibody doses or a dummy infusion. All were tested for malaria infection every two weeks for 24 weeks. Anyone who got sick was treated. 

Infections were detected by blood test in 20 people who got the higher dose, 39 people who got the lower dose and 86 who got the placebo. 

The higher dose was 88% effective, compared to the placebo. The lower dose was 75% effective. 

Protection might last during the several months of a malaria season. The idea is to someday use it alongside other malaria prevention methods such as malaria pills, mosquito nets and vaccines. Cost is uncertain, but one estimate suggests lab-made antibodies could be given for as little as $5 per child per malaria season. 

Lab-made antibodies are used to treat cancer, autoimmune diseases and COVID-19, said Dr. Johanna Daily of Albert Einstein College of Medicine in New York, who was not involved in the study. 

“The good news is now we have another, immune-based therapy to try to control malaria,” Daily said. 
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China’s third and final module docked with its permanent space station Tuesday to further a decadeslong effort to maintain a constant crewed presence in orbit, as its competition with the United States grows increasingly fierce.

The Mengtian module arrived at the Tiangong station early Tuesday morning, state broadcaster CCTV said, citing the China Manned Space Agency.

Mengtian was blasted into space on Monday afternoon from the Wenchang Satellite Launch Center on the southern island province of Hainan. It was expected to take about 13 hours to complete the flight and docking mission.

A large crowd of amateur photographers, space enthusiasts and others watched the lift-off from an adjoining beach.

Many waved Chinese flags and wore T-shirts emblazoned with the characters for China, reflecting the deep national pride invested in the space program and the technological progress it represents.

“The space program is a symbol of a major country and a boost to the modernization of China’s national defense,” said Ni Lexiong, a professor at Shanghai University of political science and law, underscoring the program’s close military links.

“It is also a boost to the confidence of the Chinese people, igniting patriotism and positive energy,” Ni said.

Mengtian, or “Celestial Dream,” joins Wentian as the second laboratory module for the station, collectively known as Tiangong, or “Celestial Palace.” Both are connected to the Tianhe core module where the crew lives and works.

Like its predecessors, Mengtian was launched aboard a Long March-5B carrier rocket, a member of China’s most powerful family of launch vehicles.

Tiangong is currently populated by a crew of three astronauts — two males and one female, according to the China Manned Space Agency.

Chen Dong, Cai Xuzhe and Liu Yang arrived in early June for a six-month stay on board, during which they will complete the station’s assembly, conduct space walks and carry out additional experiments.

Following Mengtian’s arrival, an additional uncrewed Tianzhou cargo craft is due to dock with the station next month, with another crewed mission scheduled for December, at which time crews may overlap, as Tiangong has sufficient room to accommodate six astronauts.

Mengtian weighs in at about 23 tons, is 17.9 meters long and has a diameter of 4.2 meters. It will provide space for science experiments in zero gravity, an airlock for exposure to the vacuum of space and a small robotic arm to support extravehicular payloads.

The already orbiting 23-ton Wentian, or “Quest for the Heavens” laboratory is designed for science and biology experiments and is heavier than any other single-module spacecraft currently in space.

Next year, China plans to launch the Xuntian space telescope, which, while not a part of Tiangong, will orbit in sequence with the station and can dock occasionally with it for maintenance.

No other future additions to the space station have been publicly announced.

In all, the station will have about 110 cubic meters of pressurized interior space, including the 32 cubic meters added by Mengtian.

China’s crewed space program is officially three decades old this year, with the Mengtian launch being its 25th mission. But it truly got underway in 2003, when China became only the third country after the U.S. and Russia to put a human into space using its own resources.

The program is run by the ruling Communist Party’s military wing, the People’s Liberation Army, and has proceeded methodically and almost entirely without outside support. The U.S. excluded China from the International Space Station because of its program’s military ties.

Despite that, China is collaborating with the European Space Agency on experiments aboard Mengtian and is cooperating with France, Germany, Italy, Russia, Pakistan and the U.N. Office for Outer Space Affairs (UNOOSA) on a range of projects from aerospace medicine to microgravity physics, according to the Chinese Academy of Sciences.

Prior to launching the Tianhe module, China’s Manned Space Program launched a pair of single-module stations that it crewed briefly as test platforms.

The permanent Chinese station will weigh about 66 tons — a fraction of the size of the International Space Station, which launched its first module in 1998 and weighs around 465 tons.

With a lifespan of 10 to 15 years, Tiangong could one day find itself the only space station still running, if the International Space Station adheres to its 30-year operating plan.

China has also chalked up successes with uncrewed missions, and its lunar exploration program generated media buzz last year when its Yutu 2 rover sent back pictures of what was described by some as a “mystery hut” but was most likely only a rock. The rover is the first to be placed on the little-explored far side of the moon.

China’s Chang’e 5 probe returned lunar rocks to Earth for the first time since the 1970s in December 2000, and another Chinese rover is searching for evidence of life on Mars. Officials are also considering a crewed mission to the moon.

The program has also drawn controversy. In October 2021, China’s Foreign Ministry brushed off a report that China had tested a hypersonic missile two months earlier, saying it had merely tested whether a new spacecraft could be reused.

China is also reportedly developing a highly secret space plane.

China’s space program has proceeded cautiously and largely gone off without a hitch.

Complaints, however, have been leveled against China for allowing rocket stages to fall to Earth uncontrolled twice before. NASA accused Beijing last year of “failing to meet responsible standards regarding their space debris” after parts of a Chinese rocket landed in the Indian Ocean.

China’s increasing space capabilities was also featured in the latest Pentagon defense strategy released Thursday.

“In addition to expanding its conventional forces, the PLA is rapidly advancing and integrating its space, counterspace, cyber, electronic and informational warfare capabilities to support its holistic approach to joint warfare,” the strategy said.

The U.S. and China are at odds on a range of issues, especially the self-governing island of Taiwan that Beijing threatens to annex with force. China responded to a September visit to Taiwan by U.S. House Speaker Nancy Pelosi by firing missiles over the island, holding wargames and staging a simulated blockade.
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