Tuberculosis, or TB, a bacterial infection of the lungs, is one of the world’s deadliest diseases. After decades of progress, cases are on the rise once more. March 24 is World TB Day — and as Henry Ridgwell reports, there are hopes that a vaccine may be developed in the next few years to help eradicate the disease. Videographer: Henry Ridgwell
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Several African and Latin American countries on Thursday launched a major initiative to restore 300,000 kilometers of rivers by 2030, as well as lakes and wetlands degraded by human activity. 

The “Freshwater Challenge,” led by a coalition of governments that includes Colombia, the Democratic Republic of the Congo, Mexico and Gabon, is the largest river and wetland restoration project in history. 

It aims to restore degraded rivers as long as seven times the Earth’s circumference and an area of wetlands larger than India by 2030, according to a statement from the U.N. Water Conference, which ends Friday in New York City. 

The initiative calls on all governments to set national river restoration targets to restore healthy freshwater ecosystems critical to humanity’s water needs and biodiversity. 

No details were given on how the effort will be funded. 

As water shortages become more widespread globally, driven by overconsumption, pollution and climate change, freshwater ecosystems are among the most threatened on the planet. 

“The clearest sign of the damage we have done — and are still doing — to our rivers, lakes and wetlands is the staggering 83 percent collapse in freshwater species populations since 1970,” Stuart Orr of the World Wildlife Fund said in a statement, adding that the initiative may “turn this around.” 

Inger Andersen, executive director of the U.N. Environment Program, said: “Healthy rivers, lakes and wetlands underpin our societies and economies, yet they are routinely undervalued and overlooked.” 

“While countries have pledged to restore 1 billion hectares of land, the Freshwater Challenge is a critical first step in bringing a much-needed focus on freshwater ecosystems,” Anderson added. 

Martha Delgado Peralta, Mexico’s undersecretary for multilateral affairs, voiced a similar view. 

“Healthy freshwater ecosystems are central to water and food security, while tackling the climate and nature crises, and driving sustainable development,” she said. 
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In the sprawling Nairobi slum of Kibera, Renice Owino, a young computer programmer, is passing on her knowledge to disadvantaged students. Owino is the founder and driving force behind the “Code with Kids” initiative, which has reached hundreds of children in Nairobi and other areas. Saida Swaleh visited Owino’s classroom in Nairobi and has this story. Camera: Nelson Aruya.
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A rocket made almost entirely of 3D-printed parts made its launch debut Wednesday night, lifting off amid fanfare but failing three minutes into flight — far short of orbit.

There was nothing aboard Relativity Space’s test flight except for the company’s first metal 3D print made six years ago.

The startup wanted to put the souvenir into a 125-mile-high (200-kilometer-high) orbit for several days before having it plunge through the atmosphere and burn up along with the upper stage of the rocket.

As it turned out, the first stage did its job following liftoff from Cape Canaveral Space Force Station and separated as planned. But the upper stage appeared to ignite and then shut down, sending it crashing into the Atlantic.

It was the third launch attempt from what once was a missile site. Relativity Space came within a half-second of blasting off earlier this month, with the rocket’s engines igniting before abruptly shutting down.

Although the upper stage malfunctioned and the mission did not reach orbit, “maiden launches are always exciting and today’s flight was no exception,” Relativity Space launch commentator Arwa Tizani Kelly said after Wednesday’s launch.

Most of the 110-foot (33-meter) rocket, including its engines, came out of the company’s huge 3D printers in Long Beach, California.

Relativity Space said 3D-printed metal parts made up 85% of the rocket, named Terran. Larger versions of the rocket will have even more and also be reusable for multiple flights.

Other space companies also also rely on 3D-printing, but the pieces make up only a small part of their rockets.

Founded in 2015 by a pair of young aerospace engineers, Relativity Space has attracted the attention of investors and venture capitalists.

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.
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A federal judge is expected to rule soon on the fate of a pill that leads to a medication abortion. The drug in question, mifepristone, has been on the market for 20 years, but opponents of abortion rights say it is unsafe. VOA’s Carolyn Presutti explains.
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Malawi President Lazarus Chakwera is appealing for additional humanitarian assistance for thousands of Malawians displaced by Cyclone Freddy, which has killed more than 500 people in the country.

Chakwera made the urgent request to Malawi’s parliament on Wednesday, when he was presenting an assessment of the impact of the cyclone, which also hit Mozambique.

Though the country is receiving a lot of local and international assistance for the victims, he said, more aid is needed.

“So many have responded positively to our appeal, and I have personally committed to acknowledge every support, for the situation is so grave that we simply cannot take any contribution for granted,” he told lawmakers. “However, the supplies we are deploying are far from enough for the magnitude of the need.”

Malawi’s Disaster Management Affairs Department says there are more than 500,000 people who have been displaced living at 534 camps.

Chakwera told the lawmakers to bury their political differences and work together to address the devastation caused by the powerful storm.

“This is one of the darkest hours in the history of our nation,” he said. “And if we are to emerge in this dark hour and see the joy of a new dawn in the future, we must all roll up our sleeves and get to work. If we are going to see the light of a new dawn again, we must take the necessary steps now for safeguarding a brighter tomorrow for Malawians.”

Chakwera announced the government will soon introduce legislation aimed at helping to safeguard people from natural disasters.

Kondwani Nankhumwa, leader of opposition political parties in the Malawi Parliament, welcomed the plan to have legislation for disaster management and emphasized the government must deal with sanitation issues at evacuation camps to avoid the outbreak of diseases.

“Our water resources have been depleted, boreholes have been washed away, taps have been washed away,” said Nankhumwa. “Let me register a call that the government should look into this with other partners, because if we allow these people to continue drinking unprotected water from unprotected wells, then there will be an outbreak of other diseases in camp.”

Cyclone Freddy hit Malawi amid its deadliest cholera outbreak of the past two decades, which so far has killed at least 1,600 people.

The Malawi Health Ministry warned this week that the cyclone has increased the risk of the spread of other communicable diseases, such as typhoid and dysentery.
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Nearly 200 years after Ludwig van Beethoven’s death, researchers pulled DNA from strands of his hair, searching for clues about the health problems and hearing loss that plagued him.

They weren’t able to crack the case of the German composer’s deafness or severe stomach ailments. But they did find a genetic risk for liver disease, plus a liver-damaging hepatitis B infection in the last months of his life.

These factors, along with his chronic drinking, were probably enough to cause the liver failure that is widely believed to have killed him, according to a study published Wednesday in the journal Current Biology.

This Sunday marks the 196th anniversary of Beethoven’s death in Vienna on March 26, 1827, at the age of 56. The composer himself wrote that he wanted doctors to study his health problems after he died.

“With Beethoven in particular, it is the case that illnesses sometimes very much limited his creative work,” said study author Axel Schmidt, a geneticist at University Hospital Bonn in Germany. “And for physicians, it has always been a mystery what was really behind it.”

Since his death, scientists have long tried to piece together Beethoven’s medical history and have offered a variety of possible explanations for his many maladies.

Now, with advances in ancient DNA technology, researchers have been able to pull genetic clues from locks of Beethoven’s hair that had been snipped off and preserved as keepsakes. They focused on five locks that are “almost certainly authentic,” coming from the same European male, according to the study.

They also looked at three other historical locks but weren’t able to confirm those were actually Beethoven’s. Previous tests on one of those locks suggested Beethoven had lead poisoning, but researchers concluded that sample was actually from a woman.

Scientists dissolved the pieces into a solution and fished out chunks of DNA, said study author Tristan James Alexander Begg, a biological anthropologist at the University of Cambridge.

Getting genes out was a challenge, since DNA in hair gets chopped up into tiny fragments, explained author Johannes Krause, a paleogeneticist at Germany’s Max Planck Institute for Evolutionary Anthropology.

But eventually, after using up almost 3 meters of Beethoven’s hair, they were able to piece together a genome that they could study for signs of genetic disease, Krause said.

While researchers didn’t find any clear genetic signs of what caused Beethoven’s gastrointestinal issues, they found that celiac disease and lactose intolerance were unlikely causes. In the future, the genome may offer more clues as we learn more about how genes influence health, Begg said.

The research also led to a surprising discovery: When they tested DNA from living members of the extended Beethoven family, scientists found a discrepancy in the Y chromosomes that get passed down on the father’s side. The Y chromosomes from the five men matched each other — but they didn’t match the composer’s.

This suggests there was an “extra-pair paternity event” somewhere in the generations before Beethoven was born, Begg said. In other words, a child born from an extramarital relationship in the composer’s family tree.

The key question of what caused Beethoven’s hearing loss is still unanswered, said Ohio State University’s Dr. Avraham Z. Cooper, who was not involved in the study. And it may be a difficult one to figure out, because genetics can only show us half of the “nature and nurture” equation that makes up our health.

But he added that the mystery is part of what makes Beethoven so captivating: “I think the fact that we can’t know is OK,” Cooper said.
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More than 119,000 people have been injured by tear gas and other chemical irritants around the world since 2015 and about 2,000 suffered injuries from less lethal impact projectiles, according to a report released Wednesday.

The study by Physicians for Human Rights and the International Network of Civil Liberties Organizations, in collaboration with the Omega Research Foundation, took 2½ years to research. It provides a rare, partial count of casualties, compiled from medical literature, from these devices used by police around the world, including in Colombia, Chile, Hong Kong, Turkey and at Black Lives Matter protests in the United States.

Most of the data comes from cases in which a person came to an emergency room with injuries from crowd control weapons and the attending doctor or hospital staff made the effort to document it, said the report’s lead author, Rohini Haar, an emergency room physician and researcher at the University of California School of Public Health in Berkeley.

Crowd control tools become more powerful

The report on casualties from a largely unregulated industry cites an alarming evolution of crowd control devices into more powerful and indiscriminate designs and deployment, including dropping tear gas from drones.

It calls for bans on rubber bullets and on multiprojectile devices in all crowd control settings and tighter restrictions on weapons that may be used indiscriminately, such as tear gas, acoustic weapons and water cannons, which in some cases have been loaded with dyes and chemical irritants. Governments also should ensure these weapons are subject to rigorous independent testing, with testing, evaluation and approval involving law enforcement, technical specialists and health professionals, among others, the report said.

U.S. Senator Ron Wyden, a Democrat from Oregon, said the report underscores serious issues.

“These troubling global numbers echo the concerns I raised locally when Donald Trump first dispatched armed troops to Portland in 2020 with no guidance on their use of chemical munitions near schools and against protesters when most were peacefully exercising their First Amendment rights,” Wyden said. “The report’s recommendations are very worthy of consideration by the Department of Homeland Security.”

Portland, Oregon, was an epicenter of racial justice protests after George Floyd was murdered by Minneapolis police in May 2020. Police and protesters clashed, with officers firing tear gas, pepper spray and other devices, turning parts of the city into battle grounds.

Then-President Trump sent militarized federal agents to protect federal property and the violence escalated, with agents dousing the crowds with tear gas and other irritants. Bystanders and nearby residents choked on the fumes, their eyes watering and burning. Some protesters launched fireworks at agents and shined lasers in their eyes.

Portland Police Bureau spokesperson Terri Wallo Strauss noted that the department’s updated policy emphasizes “the goal of avoiding the use of force, when feasible.”

Devices can help restore order, say police

Police say crowd control devices are, if used properly, an effective tool for dispersing rioters.

“Rallies basically spin out of control when they’ve been hijacked by individuals that have come in with a nefarious purpose to create the riots, the looting, those type of things. And then, obviously, law enforcement has to come in and try their best to create a safe resolution and try to restore order,” Park City, Utah, Police Chief Wade Carpenter said during the height of the Black Lives Matter protests.

Carpenter is also an official with the International Association of Chiefs of Police, which has more than 32,000 members in more than 170 countries. The group declined to comment on the new report. But in 2019, it recommended guidelines on crowd management.

Pepper spray, or oleoresin capsicum, may be used against “specific individuals engaged in unlawful conduct or actively resisting arrest, or as necessary in a defensive capacity,” the guidelines state. It “shall not be used indiscriminately against groups of people where bystanders would be unreasonably affected, or against passively resistant individuals.”

But the internet is full of instances in which pepper spray was used against non-resisting people, including against Tyre Nichols, who was beaten to death by Memphis police in January.

Tear gas “may be deployed defensively to prevent injury when lesser force options are either not available or would likely be ineffective,” the IACP guidance states. Projectiles that are supposed to hit a surface like a street before impacting a person “may be used in civil disturbances where life is in immediate jeopardy or the need to use the devices outweighs the potential risks involved.”

Direct-fired impact munitions, including beanbag rounds, “may be used during civil disturbances against specific individuals who are engaged in conduct that poses an immediate threat of death or serious injury,” the guidance says. Protesters have been blinded and suffered brain damage from beanbag rounds.

Claims against police

Numerous lawsuits have been filed over the use of force by police during protests.

In November, the city of Portland reached a $250,000 settlement with five demonstrators in a federal lawsuit over police use of tear gas and other crowd control devices during racial justice protests.

But last month, a federal judge threw out an excessive force claim against an unnamed federal agent who fired an impact munition at the forehead of protester Donavan La Bella, fracturing his skull, as he held up a music speaker during a racial justice demonstration in Portland in 2020. La Bella continues to struggle with a severe head injury.

Haar, who is a medical adviser for Physicians for Human Rights, said the number of injured is far greater than what she compiled from medical reports.

“Basically, we knew we’re capturing sort of the tip of the iceberg,” she said. “This is just a tiny fraction of what the world is experiencing on a daily basis. The vast majority of injuries — even significant severe injuries — go unreported.”
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The U.N. secretary-general called for significant commitments and investment Wednesday to avert a growing global water crisis at the start of a major conference on the issue.  

“Water is a human right — and a common development denominator to shape a better future,” Antonio Guterres told a packed General Assembly hall. “But water is in deep trouble.”  

The three-day conference, which kicked off on World Water Day, is the first of its kind in 46 years. Activists and experts say the ongoing water crisis is a threat to the entire planet.   

According to the United Nations, a quarter of the planet — 2 billion people — does not have access to safe drinking water. It will only worsen. By 2030, the demand for fresh water is expected to exceed supply by 40% globally.  

Meanwhile, half the world — 3.6 billion people — live without safely managed sanitation. This is deadly. The World Health Organization and the U.N. children’s agency (UNICEF) say at least 1.4 million people — many of them children — die each year from preventable causes linked to dirty water and poor sanitation. Cholera and other water-related diseases are once again on the rise.   

Guterres urged massive investment in water and sanitation systems, saying the international community cannot manage an emergency with outdated infrastructure.   

Climate change is accelerating the water problem, contributing to both severe drought and floods.  

“Climate action and a sustainable water future are two sides of the same coin,” the secretary-general said. “We must spare no effort to limit global warming to 1.5 degrees Celsius and deliver climate justice to developing countries.”  

Conference organizers say game changing action is needed now to manage water better and achieve international water goals and targets to prevent a more severe crisis.

The United States announced Wednesday that it is committing more than $49 billion to advance access to climate-resilient water and sanitation infrastructure both domestically and abroad.

“These investments will help create jobs, prevent conflicts, safeguard public health, reduce the risk of famine and hunger, and enable us to respond to climate change and natural disasters,” U.S. Ambassador to the U.N. Linda Thomas-Greenfield told reporters.   

The Netherlands and Tajikistan are co-hosting the conference, which aims to get hundreds more commitments from governments, the private sector and civil society by the end of this week for its Water Action Agenda.  

“Everything we need to live a decent life is related to water — our health, food, safety, habitat, economy, infrastructure and climate,” Dutch King Willem-Alexander said at the conference. “Water security is one of the defining concerns of our time and will determine our collective sustainable future.”
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Tanzania’s Ministry of Health has confirmed five people died in a first-ever Marburg virus outbreak near the border with Uganda. The virus causes a severe hemorrhagic fever and is deadlier than the related Ebola virus, which was first suspected in the deaths. Tanzanian health officials say they are working to contain the Marburg outbreak.

Tanzania’s health minister, Ummy Mwalimu, said the mysterious and deadly outbreak in its northwest Kagera region was caused by the Marburg virus.

Mwalimu announced at a Tuesday evening press briefing the government was intensifying efforts to contain the virus, including with contact tracing.

She said among the five people who died from the virus last week were four from the same family. The additional death was a health worker.

Mwalimu said the government has successfully managed to control the rate of new infections of the disease and the disease remains confined to the same area.

Tanzania has never before recorded a case of Marburg, a virus that the World Health Organization says has a fatality rate as high as 88%.

The deaths last week were initially suspected to be Ebola, a virus related to Marburg that the WHO says has an average fatality rate of 50% but is slightly more infectious.

Marburg and Ebola have similar symptoms, such as high fever, severe headaches, and bleeding.

Last week’s outbreak occurred near the border with Uganda, which recovered from a months-long Ebola outbreak in January that caused 77 deaths.

WHO Regional Director for Africa Matshidiso Moeti said Tuesday officials were working with Tanzania to halt the Marburg virus’s spread.

WHO Tanzania representative Zabulon Yoti told the Tuesday briefing the public should remain calm as it deals with the disease.

“This is not the first time Marburg has occurred in Africa. It has happened several times in our neighboring country, Uganda, and they have typically managed to contain it through strong community involvement,” said Yoti. “I am calling upon community members to join hands with the government to ensure that contacts are identified and those who require care receive it promptly.”

The WHO says Marburg has also been found in Angola, the Democratic Republic of Congo, Kenya, and South Africa and is spread by bats to people, who then spread it through body fluids.

It was first recognized as a disease after simultaneous laboratory-related outbreaks in 1967 in the cities of Marburg and Frankfurt, Germany, and in Belgrade.

A WHO report last year said Tanzania is at high risk for infectious disease outbreaks.

Peter Bujari, who heads Health Promotion Tanzania, an activist group that raises awareness on health issues and disease control, said Marburg kills quickly and Tanzania’s health facilities often suffer from a shortage of medicine and medical supplies. Bujari said the government must aid healthcare workers who are on the front line in treating patients and receiving them, so they are not infected.

Tanzania’s Ministry of Health is providing leaflets about the Marburg virus, including how to protect oneself, and phone numbers for reporting any suspected cases.
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U.S. cases of a dangerous fungus tripled over just three years, and more than half of the country’s 50 states have now reported it, according to a new study. 

The COVID-19 pandemic likely drove part of the increase, researchers at the Centers for Disease Control and Prevention wrote in the paper published Monday by Annals of Internal Medicine. Hospital workers were strained by coronavirus patients and that likely shifted their focus away from disinfecting some other kinds of germs, they said. 

The fungus, Candida auris, is a form of yeast that is usually not harmful to healthy people but can be a deadly risk to fragile hospital and nursing home patients. It spreads easily and can infect wounds, ears and the bloodstream. Some strains are so-called superbugs that are resistant to all three classes of antibiotic drugs used to treat fungal infections. 

It was first identified in Japan in 2009 and has been seen in more and more countries. The first U.S. case occurred in 2013, but it was not reported until 2016. That year, U.S. health officials reported 53 cases. 

The new study found cases have continued to shoot up, rising to 476 in 2019, to 756 in 2020, and then to 1,471 in 2021. Doctors have also detected the fungus on the skin of thousands of other patients, making them a transmission risk to others. 

Many of the first U.S. cases were infections that had been imported from abroad, but now most infections are spread within the U.S., the authors noted. 
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