Pfizer slashed its full-year revenue forecast by 13% and said Friday it will cut $3.5 billion worth of jobs and expenses due to lower-than-expected sales of its COVID-19 vaccine and treatment.

Pfizer earned record revenue in 2021 and 2022, topping $100 billion last year, after developing its vaccine Comirnaty with German partner BioNTech SE and antiviral treatment Paxlovid on its own. Last year, revenue from those two products exceeded $56 billion.

But annual vaccination rates have dropped sharply since 2021 and demand for treatments has dipped as population-wide immunity has increased from vaccines and prior infections. Pfizer and rivals have begun selling an updated COVID vaccine for this fall.

“We remain proud that our scientific breakthroughs played a significant role in getting the global health crisis under control,” Pfizer CEO Albert Boura said in a statement. “As we gain additional clarity around vaccination and treatment rates for COVID, we will be better able to estimate the appropriate level of supply to meet demand.”

The drugmaker said it now expects 2023 revenue of between $58 billion and $61 billion, down from its prior forecast of $67 billion to $70 billion. It said the reduction was solely due to lowered expectations for its COVID-19 products.

Pfizer said it will take a noncash charge of $5.5 billion in the third quarter to write off $4.6 billion of Paxlovid and $900 million of inventory write-offs and other charges for the vaccine.

The cost-cutting program, which will target savings of at least $3.5 billion annually by the end of 2024, will include layoffs, the company said, without providing details on how many jobs will be cut or from what areas. One-time costs to achieve the savings are expected to be around $3 billion.

Shares of the New York-based company were down about 7% in extended trading.

Pfizer slashed its forecast for sales of its antiviral COVID treatment Paxlovid by about $7 billion, including a noncash $4.2 billion revenue reversal, as it agreed to allow the return of 7.9 million courses purchased by the U.S. government. It had previously expected Paxlovid revenue of about $8 billion for the year.

Pfizer said that under a deal with the U.S. government, a credit for the returned Paxlovid doses will underwrite a program to supply the drug free-of-charge to uninsured and underinsured Americans through 2028 and to patients insured under the government’s Medicare and Medicaid programs through the end of next year.

Pfizer will also provide the U.S. government 1 million courses of Paxlovid for the Strategic National Stockpile.

The company expects the drug will become commercially available to people with private insurance on January 1.

Pfizer also cut full-year revenue expectations for the COVID vaccine by about $2 billion due to lower-than-expected vaccination rates.

Pfizer said its non-COVID products remain on track to achieve 6% to 8% revenue growth year over year in 2023.
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Following another month of record-breaking temperatures throughout the globe in September, the year 2023 is all but certain to be the warmest on record, a U.S. agency said Friday.

The unwelcome news comes as world leaders prepare to meet for the U.N. Climate Change Conference in Dubai in late November where phasing out fossil fuels, the main driver of human-caused climate change, will be top of the agenda.

“There is a greater than 99% probability that 2023 will rank as the warmest year on record,” the U.S. National Oceanic and Atmospheric Administration said in its monthly update.

The calculation was based on data gathered through September and on simulations of possible outcomes based on the historical record, from 1975 to present.

“September 2023 was the fourth month in a row of record-warm global temperatures,” said NOAA chief scientist Sarah Kapnick in a statement.

“Not only was it the warmest September on record, it was far and away the most atypically warm month of any in NOAA’s 174 years of climate keeping. To put it another way, September 2023 was warmer than the average July from 2001-2010.”

Significant climate anomalies and events included Storm Daniel, which brought strong winds and unprecedented rainfall to eastern Libya, triggering widespread destruction including burst dams that killed more than 10,000 people.

An extratropical cyclone dumped more than 300 millimeters (12 inches) of rain in 24 hours over Brazilian states, triggering landslides and flooding that killed 30.

The average global temperature for September was 2.59 degrees F (1.44 degrees C) above the 20th-century average of 59.0F (15.0C), according to the NOAA data. It was 0.83F (0.46C) above the previous record from September 2020.

Holding long-term warming to 1.5C above pre-industrial levels is seen as essential to avoid the most catastrophic consequences of climate change.

Africa, Europe, North America and South America each had their warmest September on record; Asia had its second warmest, while Oceana had its third warmest, according to the NOAA data.

In the poles, Antarctica had its warmest September, while the Arctic saw its second warmest.

September 2023 also set a record for the lowest global September sea ice extent on record.

The oceans, too, experienced record-high monthly global ocean surface temperatures for the sixth consecutive month.

Despite increasing extreme weather events and record-shattering global temperatures, greenhouse gas emissions continue to rise and fossil fuels remain subsidized to the tune of $7 trillion annually.
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Thousands of people marched the streets of Ghana’s capital last week to raise awareness of breast cancer. Event organizers aimed to dispel myths about breast cancer in Africa and encourage early detection for a cure. Senanu Tord reports from Accra. (Camera: Senanu Tord and Samuel Mintah)
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Packaging producers in Kenya have begun a campaign to collect each day 1,500 tonnes of empty beverage cartons and turn them into new products. Officials say the cartons account for 30 percent of the liquid packaging board produced in Kenya. Victoria Amunga reports from Thika, Kenya. Camera and edit: Jimmy Makhulo
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NASA on Wednesday showed off its first asteroid samples delivered last month by a spacecraft — the most ever returned to Earth.

Scientists and space agency leaders took part in the reveal at Johnson Space Center in Houston.

The ancient black dust and chunks are from the carbon-rich asteroid named Bennu, almost 60 million miles away. NASA’s Osiris-Rex spacecraft collected the samples three years ago and then dropped them off sealed in a capsule during a flyby of Earth last month.

Scientists anticipated at least a cupful of rocks, far more than what Japan brought back from a pair of missions years ago. They’re still not sure about the exact quantity. That’s because the main sample chamber has yet to be opened, officials said.

“It’s been going slow and meticulous,” said the mission’s lead scientist, Dante Lauretta of the University of Arizona.

Black dust and particles were scattered around the outside edge of the chamber, according to Lauretta.

“Already this is scientific treasure,” he said.

Besides carbon, the asteroid rubble holds water in the form of water-bearing clay minerals, said NASA Administrator Bill Nelson.
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In developing countries such as Nigeria, caregivers and parents of children with cerebral palsy struggle to support the children and deal with the stigma of the disorder. Gibson Emeka visits a mother in Abuja who has left everything to care for her son. Narrated by Salem Solomon.
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Tens of millions in the Americas will have front-row seats for Saturday’s rare “ring of fire” eclipse of the sun. 

What’s called an annular solar eclipse — better known as a ring of fire — will briefly dim the skies over parts of the western U.S. and Central and South America. 

As the moon lines up precisely between Earth and the sun, it will blot out all but the sun’s outer rim. A bright, blazing border will appear around the moon for as much as five minutes, wowing sky gazers along a narrow path stretching from Oregon to Brazil. 

The celestial showstopper will yield a partial eclipse across the rest of the Western Hemisphere. 

It’s a prelude to the total solar eclipse that will sweep across Mexico, the eastern half of the U.S. and Canada in six months. Unlike Saturday, when the moon is too far from Earth to completely cover the sun from our perspective, the moon will be at the perfect distance on April 8, 2024. 

Here’s what you need to know about the ring of fire eclipse, where you can see it and how to protect your eyes: 

What’s the path of the ‘ring of fire’ eclipse? 

The eclipse will carve out a swath about 210 kilometers wide, starting in the North Pacific and entering the U.S. over Oregon around 8 a.m. PDT Saturday. It will culminate in the ring of fire a little over an hour later. From Oregon, the eclipse will head downward across Nevada, Utah, New Mexico and Texas, encompassing slivers of Idaho, California, Arizona and Colorado, before exiting into the Gulf of Mexico at Corpus Christi. It will take less than an hour for the flaming halo to traverse the U.S. 

From there, the ring of fire will cross Mexico’s Yucatan Peninsula, Belize, Honduras, Nicaragua, Costa Rica, Panama, Colombia and finally, Brazil before its grand finale over the Atlantic. 

The entire eclipse — from the moment the moon starts to obscure the sun until it’s back to normal — will last 2 1/2 to three hours at any given spot. The ring of fire portion lasts from three to five minutes, depending on location. 

Where can the eclipse be seen? 

In the U.S. alone, more than 6.5 million people live along the so-called path of annularity, with another 68 million within 322 kilometers, according to NASA’s Alex Lockwood, a planetary scientist. “So, a few hours’ short drive and you can have over 70 million witness this incredible celestial alignment,” she said. 

At the same time, a crescent-shaped partial eclipse will be visible in every U.S. state, although just barely in Hawaii, provided the skies are clear. Canada, Central America and most of South America also will see a partial eclipse. The closer to the ring of fire path, the bigger the bite the moon will appear to take out of the sun. 

Can’t see it? NASA and others will provide a livestream of the eclipse. 

How to protect your eyes 

Be sure to use safe, certified solar eclipse glasses, Lockwood stressed. Sunglasses aren’t enough to prevent eye damage. Proper protection is needed throughout the eclipse, from the initial partial phase to the ring of fire to the final partial phase. 

There are other options if you don’t have eclipse glasses. You can look indirectly with a pinhole projector that you can make yourself, including one made with a cereal box. 

Cameras — including those on cellphones — binoculars, or telescopes need special solar filters mounted at the front end. 

Seeing double 

One patch of Texas near San Antonio will be in the cross-hairs of Saturday’s eclipse and next April’s, with Kerrville near the center. It’s one of the locations hosting NASA’s livestream. 

“Is the city of Kerrville excited? Absolutely!!!” Mayor Judy Eychner said in an email. “And having NASA here is just icing on the cake!!!” 

With Saturday’s eclipse coinciding with art, music and river festivals, Eychner expects Kerrville’s population of 25,000 to double or even quadruple. 

Where’s the total eclipse in April? 

April’s total solar eclipse will crisscross the U.S. in the opposite direction. It will begin in the Pacific and head up through Mexico into Texas, then pass over Oklahoma, Arkansas, Missouri, Illinois, Indiana, Ohio, the northern fringes of Pennsylvania and New York, and New England, before cutting across Canada into the North Atlantic at New Brunswick and Newfoundland. Almost all these places missed out during the United States’ coast-to-coast total solar eclipse in 2017. 

It will be 2039 before another ring of fire is visible in the U.S., and Alaska will be the only state then in the path of totality. And it will be 2046 before another ring of fire crosses into the U.S. Lower 48. That doesn’t mean they won’t be happening elsewhere: The southernmost tip of South America will get one next October, and Antarctica in 2026. 

Going after the science 

NASA and others plan a slew of observations during both eclipses, with rockets and hundreds of balloons soaring. 

“It’s going to be absolutely breathtaking for science,” said NASA astrophysicist Madhulika Guhathakurta. 

Embry-Riddle Aeronautical University’s Aroh Barjatya will help launch three NASA-funded sounding rockets from New Mexico’s White Sands Missile Range before, during and after Saturday’s eclipse. The goal is to see how eclipses set off atmospheric waves in the ionosphere nearly 320 kilometers up that could disrupt communications. 

Barjatya will be just outside Saturday’s ring of fire. And he’ll miss April’s full eclipse, while launching rockets from Virginia’s Wallops Island. 

“But the bittersweet moment of not seeing annularity or totality will certainly be made up by the science return,” he said. 
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October 14 is World Migratory Bird Day in the Southern Hemisphere. To better forecast bird migration, scientists are using machine learning and next-generation radar. The resulting “BirdCasts” offer new ways to help birds at risk. Shelley Schlender reports from the Rocky Mountain state of Colorado.
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In many African societies, elders are highly regarded as powerful figures who keep the culture alive and guide the young. But sometimes that power doesn’t help when it comes to obtaining health care. Juma Majanga reports from Nairobi, Kenya. (Camera and produced by: Jimmy Makhulo)
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Athletes from 20 countries took the field in Malaysia for the fourth World Deaf Football Championships. Ukraine is the men’s champion, and the United States won the women’s crown. As Dave Grunebaum reports, the athletes are succeeding on and off the field.
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Monday is World Mental Health Day.

This year’s theme is “Mental health is a basic universal human right.”

People all over the world who have mental health conditions, according to the World Health Organization, face discrimination.

“Having a mental health condition should never be a reason to deprive a person of their human rights or to exclude them from decisions about their own health,” WHO said in a statement. “Yet all over the world, people with mental health conditions continue to experience a wide range of human rights violations.”

The WHO says, “one in eight people globally are living with mental health conditions, which can impact their physical health, their well-being, how they connect with others, and their livelihoods.”

World Mental Health Day was initiated in 1992 by the World Federation for Mental Health and since then has gained momentum as more people become aware of how essential good mental health is to a person’s overall well-being.

The World Federation for Mental Health has been bringing awareness to the needs of people with mental health issues since 1948.
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In fifth grade, Stella Gage’s class watched a video about puberty. In ninth grade, a few sessions of her health class were dedicated to the risks of sexual behaviors.

That was the extent of her sex education in school. At no point was there any content that felt especially relevant to her identity as a queer teenager. To fill the gaps, she turned mostly to social media.

“My parents were mostly absent, my peers were not mature enough, and I didn’t have anyone else to turn to,” said Gage, who is now a sophomore at Wichita State University in Kansas.

Many LGBTQ+ students say they have not felt represented in sex education classes. To learn about their identities and how to build healthy, safe relationships, they often have had to look elsewhere.

As lawmakers in some states limit what can be taught about sex and gender, it will be that much more difficult for those students to come by inclusive material in classrooms.

New laws targeting LGBTQ+ people have been proliferating in GOP-led states. Some elected officials, including candidates for the Republican presidential nomination, have been pushing to remove LGBTQ+ content from classrooms.

Sex education curriculum varies widely. Some groups including Planned Parenthood have called for sex education to be inclusive of LGBTQ+ students, but some states outright forbid such an approach.

The penal code in Texas, for one, still says curriculum developed by the Department of State Health Services must say homosexuality is not acceptable and is a criminal offense, even though such language was deemed unconstitutional by the U.S. Supreme Court in 2003. Attempts in the Legislature to remove that line from state law have failed.

In practice, LGBTQ+ students say they have looked elsewhere for sex education. Some described watching their peers turn to pornography, and others said they watched videos on YouTube about how to tell if someone is gay and how to flirt with people of the same sex.

Gage grew up in Oklahoma before her military family relocated and she spent her eighth and ninth grade years in a U.S. Department of Defense school in the Netherlands. She then finished high school in Kansas, where she began to recognize she wasn’t attracted only to men.

Not seeing a safe outlet at her high school to explore who she was, she went online to research for herself the history of the LGBTQ+ community in the U.S.

“I started to realize there is a huge portion of our history that is conveniently left out. But that history is important to queer youth,” she said. She never really questioned gender or social norms, she said, until she started to learn about discrimination others have faced throughout history. “We have such rigid boxes that we expect people to fit into. If you didn’t fit, you were called slurs. I wasn’t really aware that if you strayed from those norms that people would feel you were attacking their way of life.”

Still, the internet contains vast amounts of false information. Some advocates worry students turning to the internet to fill gaps in sex education will struggle to find their way through the morass.

“Any time you have a political controversy, there is a greater potential for a lot more disinformation to be generated,” said Peter Adams, senior vice president of research and design at the News Literacy Project.

When schools address sexuality, it is often in the context of disease prevention or anti-bullying programs. School can be a difficult place if your identity is seen only in such negative ways, said Tim’m West, a former teacher and now executive director of the LGBTQ Institute at the National Center for Civil and Human Rights in Atlanta. West can relate: He grew up in Arkansas as a queer Black kid and preacher’s son and was constantly made to feel ashamed.

“What if you are a boy in high school that knows you like boys, and you sit in a divided room and listen to a teacher explain how not to have sex with girls. You would be sitting there rolling your eyes, because that is not your issue. But you also haven’t been given any instructions on how to protect yourself should you experiment with a person of the same gender,” West said.

Students need more applicable sex education regardless of their gender identity or expression, said Gage, who volunteers with a youth justice advocacy group and is also president of the Planned Parenthood Generation Action Chapter at Wichita State.

“We all have to make large decisions for ourselves about our sexuality and reproductive health. Those decisions should be grounded in knowledge,” she said.

Growing up in Washington, D.C., Ashton Gerber had more sex education classes than most. But Gerber, who is transgender, said the lessons weren’t all that applicable to their experience.

“Even if you can have sex education every day of the year, there is always going to be something that gets left out,” said Gerber, who is a student at Tufts University in Massachusetts. Gerber said educators should point students to trusted online resources so they can do their own research.

Not knowing who you are is a horrible feeling many LGBTQ+ students wrestle with, Gage said. But equally horrible is not feeling accepted once you do understand your sexual identity.

“Had I known then what I know now, I would have felt safe and confident coming out sooner,” Gage said. “No one should feel like they don’t understand themselves because we are forced to conformity in a world that doesn’t care. We can all be inclusive.” 
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A dose of patience may come in handy at the pharmacy counter this fall.

Drug and staffing shortages haven’t gone away. Stores are starting their busiest time of year as customers look for help with colds and the flu. And this fall, pharmacists are dealing with a new vaccine and the start of insurance coverage for COVID-19 shots.

Some drugstores have addressed their challenges by adding employees at busy hours. But experts say many pharmacies, particularly the big chains, still don’t have enough workers behind the counter.

Chris Adkins said he left his job as a pharmacist with a major drugstore chain a couple years ago because of the stress. Aside from filling and checking prescriptions, Adkins routinely answered the phone, ran the register and stocked pharmacy shelves.

“I just didn’t have time for the patients,” he said. “I am OK working hard and working long hours, but I just felt like I was not doing a good job as a pharmacist.”

In recent years, drugstores have struggled to fill open pharmacist and pharmacy technician positions, even as many have raised pay and dangled signing bonuses.

Larger drugstore chains often operate stores with only one pharmacist on duty per shift, said Richard Dang, an assistant professor of clinical pharmacy at the University of Southern California. That kind of thin staffing can make it hard to recruit employees.

“I think that many pharmacists in the profession are hesitant to work for a company where they don’t feel supported,” said Dang, a former president of the California Pharmacists Association.

Customers have noticed.

John Staed, of Pelham, Alabama, said a CVS pharmacist gave him the wrong prescription about a decade ago: the pills were a different color than usual. He worries the chances for another mistake could increase as pharmacists take on more work.

“These pharmacists always look stressed,” he said.

A CVS spokeswoman said the company is focused on addressing concerns raised by its pharmacists and has taken several actions, including “providing additional pharmacy resources” in markets that need support. She declined to say how many pharmacists or technicians the company has hired.

Former Walgreens CEO Rosalind Brewer said in late June that the company had added more than 1,000 pharmacists in the second quarter, but was running into a shortage of job candidates. Walgreens is adding processing centers around the country to ease some of the prescription workload for its stores.

Brewer, who left in late August, also said the company was limiting hours at 1,100 pharmacies, or about 12% of its U.S. locations. That was down from 1,600 earlier this year, but a company executive has said it doesn’t expect to return all pharmacies to normal operating hours by year’s end.

Labor strife and staffing shortages in health care are not isolated to drugstores, as the recent Kaiser Permanente strike shows.

But drugstores have some additional challenges in the fall. Many customers come to them for vaccines for COVID-19, flu and pneumonia. Plus, federal officials have approved a new shot for people ages 60 and older for a virus called RSV.

All told, CVS touts in a pharmacy counter brochure that the company can offer more than 15 vaccines to customers.

Ongoing drug shortages also have kept pharmacy workers on the phone more.

Jonathan Marquess said one of his drugstores fielded 100 questions one day last fall about the antibiotic amoxicillin and the attention deficit-hyperactivity disorder treatment Adderall, two drugs in short supply.

Marquess runs several independent pharmacies in Georgia and serves on the National Community Pharmacists Association board. He has done a few things to help his stores adapt to the extra workload, he said, including training all employees to answer basic questions about vaccines.

Marquess also adds extra staff when he knows they will have an influx of customers, like when a nearby company sends its employees over for vaccines.

“We learned from our experiences,” he said. “Training your entire staff is very, very important.”

Pharmacists say customers aren’t powerless and can help things run smoothly.

People should bring all their insurance cards to vaccine appointments, especially since insurance coverage is new for the COVID-19 shots, Marquess said.

Dang said customers should avoid showing up right after pharmacies reopen from a lunch break or just before they close, times when pharmacists and technicians are especially busy.

Making appointments for vaccines gives pharmacy workers a better sense for their workload. Calling several days in advance for a prescription refill also helps, said Jen Cocohoba, a pharmacy professor at University of California San Francisco.

“That tiny piece of control can help, because there’s so many things you cannot predict when you’re inside the community pharmacy,” Cocohoba said.
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A massive number of migrating birds collided with McCormick Place — a Chicago convention center — this week, resulting in an unprecedented number of bird deaths.

Dave Willard has collected dead and injured birds from around the center during the migration season for about 40 years. In an interview with the Audubon website, Willard said that he and his colleagues collected 964 dead birds and approximately 80 “stunned live ones.”

“It was truly unprecedented,” he said of Thursday’s event.

Hundreds more dead and injured birds were subsequently found around the city.

Before this week’s catastrophe, the largest number of dead birds he had collected was 200.

“Unfortunate weather” combined with “disorienting brightly lit buildings” confused the birds, resulting in the high death and injury numbers.

“You pick up a Rose-breasted Grosbeak and realize, if it hadn’t been for a building in Chicago, it would be spending its winter in the foothills of the Andes,” Willard said. “It’s just a shame that a city can’t be less of an obstacle.”
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Spanish company PLD Space launched its reusable Miura-1 rocket early on Saturday from a site in southwestern Spain, carrying out Europe’s first fully private rocket launch and offering hope for the continent’s stalled space ambitions.

The startup’s test nighttime launch from Huelva came after two previous attempts were scrubbed. The Miura-1 rocket, named after a breed of fighting bulls, is as tall as a three-story building and has a 100-kilogram cargo capacity. The launch carries a payload for test purposes, but this will not be released, the company said.

Mission control video showed engineers cheering as the rocket gained altitude against the dark nighttime sky, shouting for joy and congratulating one another.

A first attempt to launch the Miura-1 rocket in May was abandoned due to strong high-altitude winds. A second attempt in June failed when umbilical cables in the avionics bay did not all release in time, halting the lift off as smoke and flames spewed out from the rocket.

Airspace, areas of the sea and roads were closed around the high-security launch site ahead of the launch.

Europe’s efforts to develop capabilities to send small satellites into space are in focus after a failed orbital rocket launch by Virgin Orbit from Britain in January. That system involved releasing the launcher from a converted Boeing 747. Competitors lining up to join the race to launch small payloads include companies in Scotland, Sweden and Germany.

Saturday’s mission on the Miura-1 demonstrator was the first of two scheduled suborbital missions. However, analysts say the most critical test of its ambitions will be the development of orbital services on the larger Miura-5, planned for 2025.

In July, the last launch of Europe’s largest rocket, the premier Ariane 5 space launcher, took place at the European spaceport in Kourou, French Guiana.

Europe has until recently depended on Ariane 5 and its 11-tonne-plus capacity for heavy missions, as well as Russia’s Soyuz launcher for medium payloads and Italy’s Vega, which is also launched from Kourou, for small ones.

The end of Ariane 5 has left Europe with virtually no autonomous access to space until its successor, Ariane 6, is launched. Russia halted access to Soyuz in response to European sanctions over the Russian invasion of Ukraine, the upgraded Vega-C has been grounded for technical reasons and Ariane 6 is delayed until next year.

The European Space Agency said last week that Vega-C would not return to service until the fourth quarter of 2024, following a failed mission last December.
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