In labs across the United States, scientists are working on innovative tests using animals and insects to detect cancer earlier. As VOA’s Dora Mekouar reports, recent research suggests bees and dogs can sniff out the disease sooner than machines can.
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Geneva — The World Health Organization on Tuesday listed 17 pathogens that cause widespread disease and death, including HIV, malaria and tuberculosis, for which it said new vaccines were “urgently needed.”

The U.N. health agency said that it with its list was providing the first global effort to systematically prioritize endemic pathogens based on criteria including disease burdens, antimicrobial resistance risk and the socioeconomic impact.

“We need to do this because we would like to shift the focus from developing vaccines away from commercial returns towards regional and global health needs,” Mateusz Hasso-Agopsowicz, a WHO vaccine specialist, told reporters in Geneva via video link from Poland.

The study reconfirms longstanding priorities for vaccine research and development, including HIV, malaria and tuberculosis — three diseases that collectively kill nearly 2.5 million people each year, WHO said.

But it also identifies lesser-known pathogens as top disease control priorities, highlighting the urgency to develop new vaccines for pathogens that are becoming increasingly resistant to antimicrobials.

Among them was Group A streptococcus, which causes severe infections and contributes to some 280,000 deaths from rheumatic heart disease each year, mainly in lower-income countries.

Ita also highlights the dangers of Klebsiella pneumoniae — a bacterium that is responsible for around 40% of neonatal deaths due to blood infection, or sepsis, in low-income countries.

These vaccines “would not only significantly reduce diseases that greatly impact communities today but also reduce the medical costs that families and health systems face,” WHO vaccine chief Kate O’Brien said in a statement.

Vaccines for the various pathogens listed are at different stages of development, WHO said, with some like ones for HIV, Group A streptococcus and hepatitis C virus still at the research stage. 

Others, like ones for dengue and tuberculosis, have been developed and are approaching regulatory approval or introduction.

Hasso-Agopsowicz explained that the 17 listed pathogens were wreaking the most havoc in lower-income countries, explaining why more progress has not been made previously on developing vaccines against them.

“What typically has happened in the past is that vaccine research and development has been influenced by profitability of new vaccines. What that means is that diseases that severely affect low-income regions unfortunately receive much less attention,” he said.

With the new list, he said, “we want to change the focus… so that the new vaccine research and development is driven by health burden and not just commercial opportunities.”
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Goma, Congo — Some health officials say mpox cases in Congo appear to be “stabilizing” — a possible sign that the main epidemic for which the World Health Organization made a global emergency declaration in August might be on the decline.  

In recent weeks, Congo has reported about 200 to 300 lab-confirmed mpox cases every week, according to WHO. That’s down from nearly 400 cases a week in July. The decline is also apparent in Kamituga, the mining city in the eastern part of Congo where the new, more infectious variant of mpox first emerged.  

But the U.N. health agency acknowledged Friday that only 40% to 50% of suspected infections in Congo were being tested — and that the virus is continuing to spread in some parts of the country and elsewhere, including Uganda.  

While doctors are encouraged by the drop in infections in some parts of Congo, it’s still not clear what kinds of physical contact is driving the outbreak. Health experts are also frustrated by the low number of vaccine doses the central African nation has received — 265,000 — and say that delivering the vaccine to where it’s needed in the sprawling country is proving difficult. WHO estimates 50,000 people have been immunized in Congo, which has a population of 110 million.  

Scientists also say there needs to be an urgent, broader vaccination effort for the entire continent to halt mpox’s spread and avoid further worrisome genetic mutations, like the one detected earlier this year in Congo after months of low-level circulation.  

“If we miss this opportunity, the likelihood of another significant outbreak increases substantially,” said Dr. Zakary Rhissa, who heads operations in Congo for the charity Alima.  

So far this year, there have been roughly 43,000 suspected cases in Africa and more than 1,000 people have died, mostly in Congo.  

“We’ve seen how past outbreaks, such as the one in Nigeria in 2017, can lead to larger global events if not effectively contained,” he said. The 2017 epidemic ended up leading to the 2022 global outbreak of mpox that affected more than 100 countries.  

Rhissa said the decline in cases in Kamituga — where mpox initially spread among sex workers and miners — is an opening to put more programs in place for vaccination, surveillance and education.  

Georgette Hamuli, an 18-year-old sex worker, hadn’t been aware of mpox until immunization teams arrived last week in the poor neighborhood where she works in Goma, the biggest city in eastern Congo.  

“They told us we’re highly exposed to the risk of infection,” she said. “We insist on condoms with our clients, but some refuse … if they don’t want to use a condom, they double the amount they pay.”  

Hamuli said she and other friends who are sex workers each received 2,000 Congolese francs ($0.70) from a charity to get vaccinated against mpox — but it wasn’t the money that swayed her. 

“The vaccine is also necessary,” she said. “I think we’re now protected.”   

The Africa Centers for Disease Control and Prevention has estimated Congo needs at least 3 million mpox vaccines to stop the virus, and another 7 million for the rest of Africa. So far, WHO and partners have allocated 900,000 vaccines to nine African countries affected by mpox and expect 6 million vaccines to be available by the end of this year.  

Mpox epidemics in Burundi, Kenya, Rwanda and Uganda had their origins in Congo, and a number of cases in travelers have also been identified in Sweden, Thailand, Germany, India and Britain.  

Fewer than half of the people who are most at risk in Congo have been vaccinated, according to Heather Kerr, Congo director for the International Rescue Committee.  

“We only have a tiny amount of vaccines, and nothing for the kids,” she said.  

The vaccines for Congo are largely coming from donor countries like the U.S and through UNICEF, which mainly uses taxpayer money to buy the shots.  

“We’re getting a charitable approach where we only see very small donations of vaccines to Africa,” said Dr. Chris Beyrer, director of the Global Health Institute at Duke University. “What we need is a public health approach where we immunize populations at scale.”  

Drugmaker Bavarian Nordic, which makes the most widely used mpox vaccine, said it would sell shots destined for Africa at the lowest price possible.  

The advocacy group Public Citizen estimated UNICEF paid $65 per dose of the Jynneos mpox vaccine made by Bavarian Nordic, far higher than nearly all other vaccines used in public health programs. 

Dr. Salim Abdool Karim, an infectious diseases expert at South Africa’s University of KwaZulu-Natal, said mpox outbreaks typically peak and disappear quickly because of how the virus spreads. This time, however, he said there are two complicating factors: the virus’ transmission via sex and the continued spillover from infected animals.  

“We’re in new territory with mpox this time,” he added. “But we’re never going to solve this until we vaccinate most of our people.” 
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ADDIS ABABA — As the price of fuel soared in Ethiopia earlier this year, Awgachew Seleshi decided to buy an electric car. That aligned with the government’s new efforts to phase out gas-powered vehicles. But months later, he’s questioning whether it was the right decision.  

He faces a range of issues, from the erratic supply of electricity in Addis Ababa, the capital, to the scarcity of spare parts.  

“Charging my car has been a challenge,” the civil servant said. “Spare parts that are imported from China are expensive, few mechanics are able to fix such cars and the resale value of such cars is poor.”  

Seleshi’s troubles point to wider challenges for Ethiopia. In January, the East African country became the first in the world to ban the importation of non-electric private vehicles. 

 The decision eased pressure on authorities who spend scarce foreign currency to subsidize the cost of fuel, but it also reflected growing enthusiasm for electric vehicles as the world demands more green technologies to reduce climate-changing emissions.  

Earlier this month, Ethiopia’s government raised the price of fuel by up to 8% as part of a plan to gradually end all fuel subsidies in Africa’s second-most populous country.  

Authorities have claimed some success in enforcing the ban on non-electric vehicles entering Ethiopia, and more than 100,000 electric cars are now being imported into the country each month.  

The official target is to increase the monthly import figure to 500,000 by 2030. By that time, a big new dam Ethiopia has built on the Nile River is expected to be producing power at full capacity.  

Ethiopian Prime Minister Abiy Ahmed, in a televised address earlier this year, said the Grand Renaissance Dam will start generating more than 5,000 megawatts of electric power within a year. Authorities say such capacity would support the transition to electric vehicles.  

For now, many in Addis Ababa, a city of more than 5 million people, are doubtful the country can achieve its ambitious goals for electric vehicles without further needed infrastructure and services.  

The few garage owners who can fix broken electric cars say they are overwhelmed, while customers say they are being overcharged amid an apparent lack of competition.  

“There are two or three garages that can fix new energy vehicles in Ethiopia and many consumers lack awareness on how to take care of such vehicles,” said Yonas Tadelle, a mechanic in Addis Ababa. “As mechanics, we also lack the tools, the spare parts and the know-how to fix such cars.”  

Many EVs are now parked in garages and parking lots awaiting parts expected to come from China.  

Ethiopia’s minister in charge of transport, Bareo Hassen Bareo, has said he believes the country can be a model nation with a green economy legacy, with the prioritization of electric vehicles a key component.  

The government will invest in public charging stations, he told The Associated Press, and there are plans to create a plant manufacturing EV batteries locally to reduce reliance on imports.   

Private efforts have included a collaboration, which has since fizzled, between Olympian Haile Gebreselassie and South Korean carmaker Hyundai to make electric vehicles in Ethiopia. That effort is believed to have collapsed over the sourcing of materials.  

Samson Berhane, an economist based in Addis Ababa, said the sudden flood of electric vehicles into the local market despite poor infrastructure is making it difficult for customers to adapt comfortably. Some EVs sell for about $20,000.  

“Very few people are willing to take the risk of buying electric cars due to the lack of infrastructure, shortage of mechanics specialized in EV maintenance and the flooding of the market with Chinese brands that have questionable details and long-term visibility,” Berhane said.  

But he said he believes that Ethiopia is more than able to provide electricity to the expected 500,000 EV’s there within the next decade while fulfilling its industrial ambitions.  

Some Ethiopians are already giving up on electric vehicles, and the secondhand trade in gasoline-powered vehicles continues. There are at least 1.2 million vehicles across Ethiopia, and only a small fraction are electric ones.  

Businessman Yared Alemayehu bought a Chinese-made electric vehicle that he had hoped to use for a taxi service. He knew the car had a mechanical defect, but he believed it could be fixed. A mechanic disagreed.  

In the end, he sold the car at a loss and bought a Toyota Corolla — a car made in 2007 that he felt was more reliable — for the equivalent of $20,000, a sum that included the hefty taxes imposed on gasoline vehicles. Taxes can be higher than the cost of importing the vehicle.  

“In addition to having to charge my old electric car, it frequently broke, and the garage was overcharging, and the lineup at the garage was overwhelming us,” he said.  

Taxi driver Dereje Hailu, who had high hopes for his Chinese-made E-Star electric vehicle when he purchased it earlier this year, said his expectations had been dashed.  

“With such a car, I fear I might be stuck if I go far from Addis Ababa where there are no charging stations,” he said. 
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RENO, Nevada — Conservationists and a Native American tribe are suing the U.S. to try to block a Nevada lithium mine they say will drive an endangered desert wildflower to extinction, disrupt groundwater flows and threaten cultural resources.

The Center for Biological Diversity promised the court battle a week ago when the U.S. Interior Department approved Ioneer Ltd.’s Rhyolite Ridge lithium-boron mine at the only place Tiehm’s buckwheat is known to exist in the world, near the California line halfway between Reno and Las Vegas.

It is the latest in a series of legal fights over projects President Joe Biden’s administration is pushing under his clean energy agenda intended to cut reliance on fossil fuels, in part by increasing the production of lithium to make electric vehicle batteries and solar panels.

The new lawsuit says the Interior Department’s approval of the mine marks a dramatic about-face by U.S. wildlife experts who warned nearly two years ago that Tiehm’s buckwheat was “in danger of extinction now” when they listed it as an endangered species in December 2022.

“One cannot save the planet from climate change while simultaneously destroying biodiversity,” said Fermina Stevens, director of the Western Shoshone Defense Project, which joined the center in the lawsuit filed Thursday in federal court in Reno.

“The use of minerals, whether for EVs or solar panels, does not justify this disregard for Indigenous cultural areas and keystone environmental laws,” said John Hadder, director of the Great Basin Resource Watch, another co-plaintiff.

Rita Henderson, spokesperson for Interior’s Bureau of Land Management in Reno, said Friday the agency had no immediate comment.

Ioneer Vice President Chad Yeftich said the Australia-based mining company intends to intervene on behalf of the U.S. and “vigorously defend” approval of the project, “which was based on its careful and thorough permitting process.”

“We are confident that the BLM will prevail,” Yeftich said. He added that he doesn’t expect the lawsuit will postpone plans to begin construction next year.

The lawsuit says the mine will harm sites sacred to the Western Shoshone people. That includes Cave Spring, a natural spring less than 1.6 kilometers away described as “a site of intergenerational transmission of cultural and spiritual knowledge.”

But it centers on alleged violations of the Endangered Species Act. It details the Fish and Wildlife Service’s departure from the dire picture it painted earlier of threats to the 15-centimeter-tall wildflower with cream or yellow blooms bordering the open-pit mine Ioneer plans to dig. 

The mine’s permit anticipates up to one-fifth of the nearly 3.6 square kilometers the agency designated as critical habitat surrounding the plants — home to various pollinators important to their survival — would be lost for decades, some permanently.

When proposing protection of the 368 hectares of critical habitat, the service said “this unit is essential to the conservation and recovery of Tiehm’s buckwheat.” The agency formalized the designation when it listed the plant in December 2022, dismissing the alternative of less-stringent threatened status.

“We find that a threatened species status is not appropriate because the threats are severe and imminent, and Tiehm’s buckwheat is in danger of extinction now, as opposed to likely to become endangered in the future,” the agency concluded.

The lawsuit also discloses for the first time that the plant’s population, numbering fewer than 30,000 in the government’s latest estimates, has suffered additional losses since August that were not considered in the U.S. Fish and Wildlife Service’s biological opinion.

The damage is similar to what the bureau concluded was caused by rodents eating the plants in a 2020 incident that reduced the population as much as 60%, the lawsuit says.

The Fish and Wildlife Service said in its August biological opinion that while the project “will result in the long-term disturbance (approximately 23 years) of 146 acres (59 hectares) of the plant community … and the permanent loss of 45 acres (18 hectares), we do not expect the adverse effects to appreciably diminish the value of critical habitat as a whole.” 
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CALI, Colombia — After two weeks of negotiations, delegates on Saturday agreed at the United Nations conference on biodiversity to establish a subsidiary body that will include Indigenous peoples in future decisions on nature conservation, a development that builds on a growing movement to recognize the role of the descendants of some regions’ original inhabitants in protecting land and combating climate change. 

The delegates also agreed to oblige major corporations to share the financial benefits of research when using natural genetic resources. 

Indigenous delegations erupted into cheers and tears after the historic decision to create the subsidiary body was announced. It recognizes and protects the traditional knowledge systems of Indigenous peoples and local communities for the benefit of global and national biodiversity management, said Sushil Raj, Executive Director of the Rights and Communities Global Program at the Wildlife Conservation Society. 

“It strengthens representation, coordination, inclusive decision making, and creates a space for dialogue with parties to the COP,” Raj told The Associated Press, also known as the Conference of Parties. 

Negotiators had struggled to find common ground on some key issues in the final week but came to a consensus after talks went late into Friday. 

‘Historical debt’ 

The COP16 summit, hosted in Cali, Colombia, was a follow-up to the historic 2022 accord in Montreal, which included 23 measures to save Earth’s plant and animal life, including putting 30% of the planet and 30% of degraded ecosystems under protection by 2030. 

A measure to recognize the importance of the role of people of African descent in the protection of nature was also adopted in Cali. 

The Indigenous body will be formed by two co-chairs elected by COP: one nominated by U.N. parties of the regional group, and the other nominated by representatives of Indigenous peoples and local communities, the AP saw in the final document. 

At least one of the co-chairs will be selected from a developing country, taking into account gender balance, the document said. 

“With this decision, the value of the traditional knowledge of indigenous peoples, Afro-descendants and local communities is recognized, and a 26-year-old historical debt in the Convention on Biological Diversity [CBD] is settled,” Susana Muhamad, Colombia’s environment minister and COP16 president, posted on social media platform X shortly after the announcement. 

Who owns nature’s DNA was one of the most contentious and fiercely negotiated topics at the summit as tensions spiked between poorer and developed countries over digital sequence information on genetic resources, or DSI. 

Negotiators consented on Saturday morning, however, to bind big companies to share benefits when using resources from animals, plants or microorganisms in biotechnologies. 

Delegations agreed on a genetic information fee of 0.1% of companies’ revenues from products derived from such information. 

“Many of the life-saving medicines we use today come from the rainforest. It is therefore right that a portion of the income companies generate from this information goes back to protect nature,” said Toerris Jaeger, executive director of Rainforest Foundation Norway. “This is the absolute highlight from COP16.” 

Needs exceed pledges

Also adopted was an agreement to protect human health from Earth’s increasing biodiversity issues. Ecosystem degradation and loss of ecological integrity directly threaten human and animal health, environmental groups say. 

Pledges made by countries during the two weeks were far short of the billions needed to tackle plummeting global biodiversity, with only around $400 million in the fund. 

The modest pledges don’t bode well for the next U.N. climate talks, COP29, to take place in Azerbaijan beginning later this month. COP29 is expected to focus on how to generate trillions of dollars needed for the world to transition to clean energies such as solar, wind and geothermal. Raising that money will require major commitments by nations, companies and philanthropies. 

In Montreal’s biodiversity summit, wealthy nations pledged to raise $20 billion in annual conservation financing for developing nations by 2025, with that number rising to $30 billion annually by 2030. 

Global wildlife populations have plunged on average by 73% in 50 years, according to the World Wildlife Fund and the Zoological Society of London biennial Living Planet report in October. 
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