OxyContin maker Purdue Pharma LP said Saturday that it has cut its sales force in half and will stop promoting opioids to physicians, following widespread criticism of the ways that drugmakers market addictive painkillers.

The drugmaker said it will inform doctors Monday that its sales representatives will no longer be visiting physician offices to discuss its opioid products. It will now have about 200 sales representatives, Purdue said.

“We have restructured and significantly reduced our commercial operation and will no longer be promoting opioids to prescribers,” the Stamford, Connecticut-based company said in a statement.

New marketing push

Doctors with opioid-related questions will be directed to its medical affairs department. Its sales representatives will now focus on Symproic, a drug for treating opioid-induced constipation, and other potential non-opioid products, Purdue said.

Opioids were involved in more than 42,000 overdose deaths in 2016, according to the U.S. Centers for Disease Control and Prevention.

Amid the opioid epidemic, Purdue and other drugmakers have been fighting a wave of lawsuits by states, counties and cities that have accused them of pushing addictive painkillers through deceptive marketing.

The lawsuits have generally accused Purdue of significantly downplaying the risk of addiction posed by OxyContin and of engaging in misleading marketing that overstated the benefits of opioids for treating chronic, rather than short-term, pain.

Lawsuits in 14 states

At least 14 states have sued the privately held Purdue. Most recently, Alabama Attorney General Steve Marshall filed a lawsuit Tuesday accusing Purdue of deceptively marketing prescription opioids to generate billions of dollars in sales.

Purdue is also facing a federal investigation by the U.S. Attorney’s Office in Connecticut.

Purdue has denied the allegations in the various lawsuits.

It has said its drugs are approved by the U.S. Food and Drug Administration and account for only 2 percent of all opioid prescriptions.

Purdue and three executives previously pleaded guilty in 2007 to federal charges related to the misbranding of OxyContin and agreed to pay a total of $634.5 million to resolve a U.S. Justice Department probe.

That year, Purdue also reached a $19.5-million settlement with 26 states and the District of Columbia. It agreed in 2015 to pay $24 million to resolve a lawsuit by Kentucky.
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It’s been a tough week on Wall Street. The Dow Jones Industrial average closed more than 300 points higher Friday, after plunging more than 1,000 points the day before, the second steepest decline in history. The biggest dive happened Monday when the blue chip index fell more than 1,100 points. It’s enough to make even the most experienced investors swoon. But does this mean the end of the nine-year bull market? Is it time to worry? Mil Arcega spoke with economic analysts to get some answers.
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Politicians and public figures suspected of buying property with corrupt money will be forced to explain their wealth, or face the seizure of their assets under new legislation that has come into force in Britain this month. As Henry Ridgwell reports from London, the so-called Unexplained Wealth Orders have been welcomed by activists, who say the British capital is at the center of a global web of corrupt and embezzled money.
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Commissions that oversee coastal lands and water pushed the Trump administration to leave California out of plans to expand offshore drilling, saying the state will throw up any barriers possible to prevent pumping and transportation of oil.

The warning came weeks after Interior Secretary Ryan Zinke said he wants to open nearly all U.S. coastlines to offshore oil and gas drilling.

Since then, the U.S. Bureau of Ocean Energy Management has proposed six sales of drilling rights off the California coast and a seventh off Oregon and Washington between 2020 and 2023.

“Given how unpopular oil development in coastal waters is in California, it is certain that the state would not approve new pipelines or allow use of existing pipelines to transport oil from new leases onshore,” the State Lands Commission wrote in a letter Wednesday to federal officials.

The commission controls up to 3 miles (4.8 kilometers) offshore, at which point federal jurisdiction kicks in. It has not allowed drilling in the state-controlled waters since a 1969 oil spill near Santa Barbara.

State and local governments could also block the construction of helipads and other infrastructure on land needed to support offshore operations.

Laws from the 1980s

In the 1980s, many coastal cities passed ordinances to block such infrastructure when President Ronald Reagan looked to expand offshore drilling. Many of those laws remain in place.

Drillers could find ways around state and local restrictions — such as pumping oil directly onto ships for transport — but the process is expensive and may not be profitable if oil prices remain relatively low.

A separate letter from the California Coastal Commission warned that an oil spill would devastate the state’s tourism economy and coastal beauty.

The letter pointed to the Santa Barbara spill, which caused severe environmental damage, hurt the fishing industry and dissuaded tourists from visiting.

The commission has authority to review activities in federally controlled waters. It can’t block drilling but could file a lawsuit contending the move doesn’t meet ocean management plans approved jointly by the state and federal governments in the 1970s.

​’We will fight them again’

“We’ve fought similar efforts before, and we will fight them again,” Coastal Commission Chair Dayna Bochco said.

The state agencies weighed in ahead of a public meeting Thursday in Sacramento, the only opportunity for people to register their opinions in person to the U.S. Bureau of Ocean Energy Management.

Fishermen, environmentalists, surfers and other critics demonstrated outside the state Capitol before marching to the meeting at a nearby library.

Several demonstrators chanted in opposition at the open-house style meeting, where bureau scientists talked one-on-one with visitors and collected written comments.

“Why do we want to let someone start drilling for more oil when we need to be putting money into resources for green economy and green fuel,” said Jim Wilson, a 71-year-old retired mail carrier from Placerville, outside Sacramento.

California Assembly opposed

Earlier in the day, the California Assembly voted overwhelmingly to oppose renewed drilling.

“We are California and we will fight back to protect our beautiful coast,” said Assemblyman Al Muratsuchi of Torrance.

Republicans Randy Voepel of Santee and Travis Allen of Huntington Beach said California can safely harvest oil and gas. Allen, a GOP candidate for governor, said that could help lower gasoline prices.

Most of California’s outer continental shelf — the area that would be opened to drilling — is in shallow water, where operations are not complicated, said Tim Charters, senior director of government and political affairs for the National Ocean Industries Association, a trade group for the offshore energy industry.

“It’s critical to keep the dollars at home, create the jobs locally instead of sending the money overseas and creating jobs in foreign places,” he said.

Zinke angered critics when he said drilling off Florida’s coast would remain off limits, prompting California Gov. Jerry Brown and others to request a similar exemption. Regulators later said no final decision had been made about Florida.

Oregon, New Jersey protests

On Tuesday, more than 100 demonstrators gathered outside Oregon’s state Capitol in Salem to denounce the proposal. A day later in New Jersey, more than a dozen groups held a rally in the driving rain on the Asbury Park boardwalk to demonstrate their opposition.

Twenty-three meetings are planned nationwide in coastal states. Comments can be submitted online through March 9.
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Canadian Prime Minister Justin Trudeau on Thursday pitched Canadian globalism and the country’s new fast-track visa as reasons why Silicon Valley companies should consider Canada as a place to do business and spend money.

Trudeau brought his charm offensive to the San Francisco Bay Area amid increasing unease over U.S. immigration policy and while talks continue over the North American Free Trade Agreement.

The heated debate over immigration since the election of President Donald Trump has provided a clear opening for Canada to promote itself to Silicon Valley.

As American employers worry about access to foreign workers, Canada is offering a two-week, fast-track employment permit for certain workers, dubbed the “global skills strategy visa.”

Government-sponsored billboards in Silicon Valley pitch: “H1-B Problems? Pivot to Canada.” Recruiters from cities in Canada attend Canadian university alumni events in the valley, urging graduates to come home “to your next career move in the Great White North.”

Trudeau demurred when asked whether Trump’s immigration efforts are making the sales pitch easier, pointing to the power of globalism.

“We know that bringing in great talent from around the world is an enormous benefit, not just to the companies that want to do that, but to Canadian jobs and to our country as a whole, so we’re going to continue to do that,” he said.

Recruiting successes

His stops Thursday were designed to showcase recruiting successes.

Salesforce CEO Marc Benioff announced the online business software company will invest another $2 billion in its Canadian operations.

And San Francisco-based AppDirect, an online management platform whose co-CEO first met Trudeau in political science class at McGill University in Montreal, said it would add another 300 jobs in Canada in the next five years.

Trudeau is also meeting with Amazon Chief Executive Jeff Bezos as Bezos considers the location for its second headquarters. Toronto, which has created a government-sponsored innovation hub for tech companies, was the only one of several Canadian cities that applied to make the shortlist.

The San Francisco Bay Area has become increasingly important to the Canadian government, said Rana Sarkar, the consul general of Canada in San Francisco. He said it fits with the “innovation strategy” the Trudeau government has promoted since its election in 2015.

“It’s the global epicenter for many of these revolutions. We need to be here both offensively to ensure that we’re telling our story. … And we’re also here defensively to ensure that we’re here at the table when the decisions about the next economy are made,” Sarkar said.

Trudeau’s stop in San Francisco also highlights the already strong ties between Canada and California, particularly in research, academia and technology.

NAFTA

While much of the attention on the North American Free Trade Agreement has focused on physical commodities such as vehicle manufacturing, dairy and timber, skilled workers have also become increasingly mobile between the U.S., Canada and Mexico.

Google built its latest DeepMind artificial intelligence facility at the University of Alberta in Edmonton, Canada, after several of its graduates came to work on the project.

The next round of talks over the 24-year-old trade pact in Mexico later this month loomed over Trudeau’s visit. Trump has called the agreement a job-killing “disaster” on the campaign trail and has threatened to withdraw from it if he can’t get what he wants.

The lengthy talks have increased the political pressure and the rhetoric in Canada, where the stakes are high.

Trudeau declined to talk about specifics Thursday, but said Canada wants an agreement that is “win-win-win” for all three countries.

“We’re going to continue to make an argument that it’s not enough to just trade, we have to ensure that the benefits of trade are properly and fairly shared,” he said.

There are hundreds, maybe thousands — no one can say for sure — of Canadians in the tech industry in Northern California, many of them on visas made possible through the trade pact.

Without NAFTA, “those [jobs] go away. That could cause immediate disruption for the tech community” on both sides of the border, said Daniel Ujczo, an international trade lawyer based in Columbus, Ohio, who has been part of the talks, now in their sixth round.

“It’s unfortunately not an area that is up for discussion. Canada and Mexico keep raising worker mobility issues, but the U.S. won’t discuss it,” he said.

Trudeau will meet with Gov. Jerry Brown and Lt. Gov. Gavin Newsom, both Democrats, on Friday before he travels to Southern California to deliver a speech at the Ronald Reagan Presidential Library.

The location is a symbolic choice, referring to the longstanding trade relationship between the U.S. and Canada. In 1988, Reagan and then-Prime Minister Brian Mulroney signed the first free trade agreement — a precursor to NAFTA.
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U.S. stocks tumbled again Thursday as investors continued to fret about the possibility of rising inflation and higher interest rates. 

For the second time in four days, the Dow Jones industrial average sank more than 1,000 points, or 4.2 percent, to end Thursday day at 23,860.

The Standard and Poor’s Index, the benchmark for many index funds, also shed 100.66 points, or 3.8 percent, to close at 2,581. It last hit that low in mid-November.

The two indexes have dropped 10 percent from their all-time highs, set on January 26. That means they are in what is known on Wall Street as a “correction,” fueled by fears that a long stretch of low interest rates and tame inflation, which helped driven up stock prices, might be coming to an end.

As the day wore on, it became evident major U.S. stock indexes were headed toward their fifth loss in the last six days, erasing big gains in the first weeks of the new year.

Stocks began to tumble last Friday after the U.S. Labor Department reported wages grew rapidly in January, sparking concern of higher inflation and lower corporate profits.

Earlier in Europe, stock prices declined and bond yields increased after the Bank of England said it may boost interest rates in response to a strong global economy. Britain’s FTSE-100 Index fell 1.5 percent and Germany’s DAX plunged 2.6 percent.

The picture was brighter in Asia, where Japan’s Nikkei 225 Index climbed just over 1 percent, South Korea’s Kospi Index rose five-tenths of one percent, and Hong Kong’s Hang Seng Index gained four-tenths of one percent. 
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