Month: April 2019

Study Points to New Antibody Approach to Tackling Ebola, Other Infections

Scientists working on developing vaccines against Ebola have found they can “harvest” antibodies from volunteers vaccinated in research trials and use them to make treatments for the deadly viral infection.

In a study published Tuesday in the journal Cell Reports, the scientists said the approach could be used for Ebola and other newly emerging deadly diseases caused by viruses.

The technique, based on people exposed to the Ebola vaccine but not the Ebola virus itself, suggests protective therapies could be developed from people who are disease-free.

“It is a small, extra step that could lead to new antibody therapies from an increased pool of donors and with reduced risk,” said Alain Townsend, a professor at the MRC Human Immunology Unit at Britain’s Oxford University.

He noted that besides Ebola, many experimental vaccines for other life-threatening infections, such as H5N1 and H7N9 bird flu and Middle East Respiratory Syndrome (MERS), are entering clinical trials and could offer similar opportunities for antibodies to be collected.

Ebola is now spreading in Democratic Republic of Congo, where World Health Organization data show at least 676 people have been killed and more than 700 others infected in an outbreak that started eight months ago.

The largest Ebola epidemic in history swept through Sierra Leone, Liberia and Guinea in 2013-2016, killing more than 11,000 people. That outbreak prompted a global push to develop vaccines and treatments — and some, including a protective shot developed by Merck and several antibody therapies for infected patients, have been deployed in the Congo outbreak.

Antibodies intended for treatment are normally collected from the blood of people who have survived infection. But they can also be tricky to obtain and carry heightened risks such as potential persistent viruses or other pathogens.

The Oxford team decided to try using blood from trial volunteers who had been given an experimental Ebola vaccine and whose immune system had responded to the shot by making antibodies. They successfully isolated 82 antibodies taken from 11 volunteers in trial at Oxford’s Jenner Institute.

They found that despite having less time to develop, a third of the antibodies were effective at neutralizing a strain of Ebola known as Zaire — the one causing the Congo outbreak.

The scientists then made a cocktail of four of the antibodies to create a treatment, which successfully cured six guinea pigs of Ebola when it was administered three days after infection.

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Study Points to New Antibody Approach to Tackling Ebola, Other Infections

Scientists working on developing vaccines against Ebola have found they can “harvest” antibodies from volunteers vaccinated in research trials and use them to make treatments for the deadly viral infection.

In a study published Tuesday in the journal Cell Reports, the scientists said the approach could be used for Ebola and other newly emerging deadly diseases caused by viruses.

The technique, based on people exposed to the Ebola vaccine but not the Ebola virus itself, suggests protective therapies could be developed from people who are disease-free.

“It is a small, extra step that could lead to new antibody therapies from an increased pool of donors and with reduced risk,” said Alain Townsend, a professor at the MRC Human Immunology Unit at Britain’s Oxford University.

He noted that besides Ebola, many experimental vaccines for other life-threatening infections, such as H5N1 and H7N9 bird flu and Middle East Respiratory Syndrome (MERS), are entering clinical trials and could offer similar opportunities for antibodies to be collected.

Ebola is now spreading in Democratic Republic of Congo, where World Health Organization data show at least 676 people have been killed and more than 700 others infected in an outbreak that started eight months ago.

The largest Ebola epidemic in history swept through Sierra Leone, Liberia and Guinea in 2013-2016, killing more than 11,000 people. That outbreak prompted a global push to develop vaccines and treatments — and some, including a protective shot developed by Merck and several antibody therapies for infected patients, have been deployed in the Congo outbreak.

Antibodies intended for treatment are normally collected from the blood of people who have survived infection. But they can also be tricky to obtain and carry heightened risks such as potential persistent viruses or other pathogens.

The Oxford team decided to try using blood from trial volunteers who had been given an experimental Ebola vaccine and whose immune system had responded to the shot by making antibodies. They successfully isolated 82 antibodies taken from 11 volunteers in trial at Oxford’s Jenner Institute.

They found that despite having less time to develop, a third of the antibodies were effective at neutralizing a strain of Ebola known as Zaire — the one causing the Congo outbreak.

The scientists then made a cocktail of four of the antibodies to create a treatment, which successfully cured six guinea pigs of Ebola when it was administered three days after infection.

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Brazilian Government Takes Bullish Stance on Pension Reform

Senior Brazilian officials charged with steering pension reform through Congress presented a united front on Tuesday, insisting on an end to the political finger-pointing in recent weeks that threw the government’s signature reform bill into doubt.

Brazilian stocks hit a nearly three-month low last week on growing signs of political infighting and skepticism that President Jair Bolsonaro was fully committed to the political consensus-building needed to get lawmakers to pass his pension reform bill.

But the message on Tuesday from Vice President Hamilton Mourao, Labor and Pensions Secretary Rogerio Marinho and the government’s leader in the lower house, Vitor Hugo, was that the government is listening and willing to work with Congress.

“We have high expectations that parliament will approve pension reform in the coming months, and then it’s onto tax reform,” Mourao said at an event in Rio de Janeiro.

Vitor Hugo said “a page had been turned” from the tension of last week, adding that Bolsonaro and his top ministers are getting more involved in the negotiations with lawmakers to build the political support needed to get passage approved.

Still, Brazil’s benchmark Bovespa stock index slipped nearly 1%  on Tuesday tracking losses.

The government’s plan targets over 1 trillion reais ($260 billion) in savings over the next decade from a radical overhaul of the social security system. Economists insist this is needed to shore up the public finances, revive the economy and boost investor confidence in Brazil.

But the proposal is likely to be watered down as lawmakers extract concessions and exemptions. Military personnel have already secured pay raises that almost fully make up for losses from later retirement ages and more required contributions.

Marinho said that the government continues to analyze benefits for rural and disabled Brazilians, two points that have provoked the strongest opposition in Congress.

A lawmaker survey run by transparency group Atlas Politico on Tuesday showed that the government currently has the support of 171 of the 308 lawmakers needed for the bill’s passage in the lower house, which would send the proposal to the Senate.

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Brazilian Government Takes Bullish Stance on Pension Reform

Senior Brazilian officials charged with steering pension reform through Congress presented a united front on Tuesday, insisting on an end to the political finger-pointing in recent weeks that threw the government’s signature reform bill into doubt.

Brazilian stocks hit a nearly three-month low last week on growing signs of political infighting and skepticism that President Jair Bolsonaro was fully committed to the political consensus-building needed to get lawmakers to pass his pension reform bill.

But the message on Tuesday from Vice President Hamilton Mourao, Labor and Pensions Secretary Rogerio Marinho and the government’s leader in the lower house, Vitor Hugo, was that the government is listening and willing to work with Congress.

“We have high expectations that parliament will approve pension reform in the coming months, and then it’s onto tax reform,” Mourao said at an event in Rio de Janeiro.

Vitor Hugo said “a page had been turned” from the tension of last week, adding that Bolsonaro and his top ministers are getting more involved in the negotiations with lawmakers to build the political support needed to get passage approved.

Still, Brazil’s benchmark Bovespa stock index slipped nearly 1%  on Tuesday tracking losses.

The government’s plan targets over 1 trillion reais ($260 billion) in savings over the next decade from a radical overhaul of the social security system. Economists insist this is needed to shore up the public finances, revive the economy and boost investor confidence in Brazil.

But the proposal is likely to be watered down as lawmakers extract concessions and exemptions. Military personnel have already secured pay raises that almost fully make up for losses from later retirement ages and more required contributions.

Marinho said that the government continues to analyze benefits for rural and disabled Brazilians, two points that have provoked the strongest opposition in Congress.

A lawmaker survey run by transparency group Atlas Politico on Tuesday showed that the government currently has the support of 171 of the 308 lawmakers needed for the bill’s passage in the lower house, which would send the proposal to the Senate.

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Bangladesh Fashion Workers at Risk With ‘Shocking’ Reform Delays

The safety of workers making clothing for global brands like Adidas and H&M could be at risk if Bangladesh’s Supreme Court moves on Sunday to shut down a factory inspection mechanism set up by European fashion labels, campaigners said Tuesday.

The government has shown “a shocking level of unreadiness” to take over from the Bangladesh Accord — signed by about 200 major brands and unions after the 2013 Rana Plaza disaster — said four groups, including Clean Clothes Campaign.

“At this moment, the Accord is the only organization that is meaningfully and transparently making factories safer,” said Christie Miedema, a spokeswoman for the alliance of garment industry unions and advocacy organizations.

“A forced early transition could jeopardize the finalization of the vital elements of remediation,” she said, referring to Accord’s efforts to make some 1,700 factories safe before it is scheduled to hand over to government inspectors in 2021.

Bangladesh, the world’s second-largest garment producer, has said that it is capable of monitoring the country’s thousands of factories through its Remediation Coordination Cell (RCC), which is currently responsible for the safety of 745 factories.

Worker safety has come under scrutiny in Bangladesh after the Rana Plaza factory collapsed, killing about 1,100 people, and putting big brands under pressure to ensure their products are responsibly sourced.

The Supreme Court is considering an appeal by the Accord against a ruling last year which ordered it to shut down, following a petition by a factory owner who was prevented from working with Accord brands and accused of false test results.

High-risk hazards

None of 745 factories under the government’s RCC inspectors has eliminated high-risk hazards — such as lockable exits that could trap workers during a fire — identified at least three years ago, Clean Clothes Campaign said in a report Tuesday.

Farid Ahmed, an official with the Department of Inspection for Factories and Establishments — which manages the RCC — said it was hard for the factories that the government inspects to implement reforms quickly.

“Most of the factory owners we deal with run in rented buildings or shared buildings,” he told Reuters. “It’s difficult for all of them to agree on a structural change.”

The Clean Clothes Campaign report said that Accord had banned 114 critically unsafe factories from supplying its signatory buyers, but half of these facilities remain open under the government’s inspection program.

“There is no indication in the government’s own records that any safety improvements have been made to these factories,” it said.

Ahmed said many factories regulated by the RCC sell to individual buyers who exert less pressure over safety standards.

“There isn’t much concern from the buyers since they aren’t that big. That adds to the difficulties,” said Ahmed.

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Bangladesh Fashion Workers at Risk With ‘Shocking’ Reform Delays

The safety of workers making clothing for global brands like Adidas and H&M could be at risk if Bangladesh’s Supreme Court moves on Sunday to shut down a factory inspection mechanism set up by European fashion labels, campaigners said Tuesday.

The government has shown “a shocking level of unreadiness” to take over from the Bangladesh Accord — signed by about 200 major brands and unions after the 2013 Rana Plaza disaster — said four groups, including Clean Clothes Campaign.

“At this moment, the Accord is the only organization that is meaningfully and transparently making factories safer,” said Christie Miedema, a spokeswoman for the alliance of garment industry unions and advocacy organizations.

“A forced early transition could jeopardize the finalization of the vital elements of remediation,” she said, referring to Accord’s efforts to make some 1,700 factories safe before it is scheduled to hand over to government inspectors in 2021.

Bangladesh, the world’s second-largest garment producer, has said that it is capable of monitoring the country’s thousands of factories through its Remediation Coordination Cell (RCC), which is currently responsible for the safety of 745 factories.

Worker safety has come under scrutiny in Bangladesh after the Rana Plaza factory collapsed, killing about 1,100 people, and putting big brands under pressure to ensure their products are responsibly sourced.

The Supreme Court is considering an appeal by the Accord against a ruling last year which ordered it to shut down, following a petition by a factory owner who was prevented from working with Accord brands and accused of false test results.

High-risk hazards

None of 745 factories under the government’s RCC inspectors has eliminated high-risk hazards — such as lockable exits that could trap workers during a fire — identified at least three years ago, Clean Clothes Campaign said in a report Tuesday.

Farid Ahmed, an official with the Department of Inspection for Factories and Establishments — which manages the RCC — said it was hard for the factories that the government inspects to implement reforms quickly.

“Most of the factory owners we deal with run in rented buildings or shared buildings,” he told Reuters. “It’s difficult for all of them to agree on a structural change.”

The Clean Clothes Campaign report said that Accord had banned 114 critically unsafe factories from supplying its signatory buyers, but half of these facilities remain open under the government’s inspection program.

“There is no indication in the government’s own records that any safety improvements have been made to these factories,” it said.

Ahmed said many factories regulated by the RCC sell to individual buyers who exert less pressure over safety standards.

“There isn’t much concern from the buyers since they aren’t that big. That adds to the difficulties,” said Ahmed.

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Poland Plans Stricter Rules for Transport Companies Like Uber

Poland will require Uber to use licensed taxi drivers from next year, under a plan approved by the cabinet Tuesday aimed at creating fair competition.

Polish taxi drivers have staged protests demanding equal rules for themselves and drivers of app-based car firms such as Uber, mytaxi and itaxi, which have become hugely popular in Polish cities, but licensed taxi drivers complain they are driving down taxi fares.

They plan to hold another demonstration in Warsaw next week.

The new law to impose stricter rules on such app-based transport companies, if passed by parliament, will come into effect at the start of next year.

Uber has faced opposition to its low-cost service in other countries around the world, including in Poland’s neighbor Czech Republic which also plans to require Uber drivers to be licensed.

In Poland, there had been speculation that Uber and other app-based taxi firms would come under greater scrutiny.

Daily newspaper Rzeczpospolita reported in January, citing Uber’s regional chief and Polish ministers, that Uber will invest 37 million zloty ($9.7 million) in its R&D center near Krakow this year, creating an additional 250 jobs. The newspaper speculated that Uber was hoping the job creation would be welcomed by the government and discourage it from tightening regulations against the company.

Uber did not respond to an emailed request for comment Tuesday.

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Dutch Security Agency Warns Against Chinese, Russian Technology

The Dutch security service advised the government Tuesday not to use technology from countries with active cyber-hacking campaigns against the Netherlands, such as China and Russia.

The recommendation came as the Dutch government is weighing options for a new 5G telecommunications network in the coming years and seeks to replace its domestic emergency services network, known as C2000.

The AIVD security agency flagged Chinese and Russian attempts at digital espionage as a major security risk.

“It is undesirable for the Netherlands to exchange sensitive information or for vital processes to depend on the hardware or software of companies from countries running active cyber programmes against Dutch interests,” the AIVD said in its annual report.

Prime Minister Mark Rutte has refused to rule out doing business with Chinese technology companies, even as key allies the United States and Australia restricted Huawei Technologies from accessing its next-generation mobile networks on national security grounds.

Washington has said that Huawei is at the beck and call of the Chinese state, warning that its network equipment may contain “back doors” that could open them up to cyberespionage.

Huawei says such concerns are unfounded.

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Study: Prostate Cancer Death Rates Stabilizing

Death rates from prostate cancer — the most commonly diagnosed cancer in men — have stabilized or declined in dozens of countries since the turn of the century, the American Cancer Society reported Tuesday.

In 33 of 44 countries surveyed, the incidence of prostate cancer had stabilized in the last five years for which data was available — and in seven countries, it was down, the report found.

Only four of the countries surveyed, including Bulgaria, saw an increased incidence of prostate cancer, it said.

“In the most recent five years of data examined, prostate cancer incidence and mortality rates are decreasing or stabilizing in most parts of the world,” the study’s author MaryBeth Freeman said.

Prostate cancer deaths were down in 14 countries surveyed and stable in 54 others. Only three countries experienced a rise in prostate cancer deaths, according to the study findings, which were presented Tuesday at a conference in Atlanta.

The United States had the biggest drop in prostate cancers, which Freeman attributed to a decline in the use of a controversial diagnostic test that identified too many non-dangerous tumors.

The incidence of prostate cancers rose in the U.S. during the 1980s and early 1990s when the PSA, or Prostate-Specific Antigen, blood test became widely available.

The test is imprecise, however, and yields too many false positives. It identifies higher than normal levels of PSA, a protein produced by the prostate, which could be a sign of cancer but is more often a symptom of other diseases.

Moreover, some prostate cancers are not aggressive and do not grow enough to pose a risk.

A false positive, on the other hand, can have harmful consequences for the patient: anxiety, complications linked to biopsies, or anti-cancer treatments.

In 2012, the U.S. Preventive Services Task Force, an expert panel that reviews the effectiveness of preventive clinical services, advised against use of the PSA test.

In 2018, it revised the recommendation to say that taking the test should be an “individual” decision for men 55 to 69. At 70 and after, it advised against its use.

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Study: Prostate Cancer Death Rates Stabilizing

Death rates from prostate cancer — the most commonly diagnosed cancer in men — have stabilized or declined in dozens of countries since the turn of the century, the American Cancer Society reported Tuesday.

In 33 of 44 countries surveyed, the incidence of prostate cancer had stabilized in the last five years for which data was available — and in seven countries, it was down, the report found.

Only four of the countries surveyed, including Bulgaria, saw an increased incidence of prostate cancer, it said.

“In the most recent five years of data examined, prostate cancer incidence and mortality rates are decreasing or stabilizing in most parts of the world,” the study’s author MaryBeth Freeman said.

Prostate cancer deaths were down in 14 countries surveyed and stable in 54 others. Only three countries experienced a rise in prostate cancer deaths, according to the study findings, which were presented Tuesday at a conference in Atlanta.

The United States had the biggest drop in prostate cancers, which Freeman attributed to a decline in the use of a controversial diagnostic test that identified too many non-dangerous tumors.

The incidence of prostate cancers rose in the U.S. during the 1980s and early 1990s when the PSA, or Prostate-Specific Antigen, blood test became widely available.

The test is imprecise, however, and yields too many false positives. It identifies higher than normal levels of PSA, a protein produced by the prostate, which could be a sign of cancer but is more often a symptom of other diseases.

Moreover, some prostate cancers are not aggressive and do not grow enough to pose a risk.

A false positive, on the other hand, can have harmful consequences for the patient: anxiety, complications linked to biopsies, or anti-cancer treatments.

In 2012, the U.S. Preventive Services Task Force, an expert panel that reviews the effectiveness of preventive clinical services, advised against use of the PSA test.

In 2018, it revised the recommendation to say that taking the test should be an “individual” decision for men 55 to 69. At 70 and after, it advised against its use.

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After the Moon in 2024, NASA Wants to Reach Mars by 2033

NASA has made it clear they want astronauts back on the Moon in 2024, and now, they are zeroing in on the Red Planet – the US space agency confirmed that it wants humans to reach Mars by 2033.

Jim Bridenstine, NASA’s administrator, said Tuesday that in order to achieve that goal, other parts of the program – including a lunar landing – need to move forward more quickly.

“We want to achieve a Mars landing in 2033,” Bridenstine told lawmakers at a congressional hearing on Capitol Hill.

“We can move up the Mars landing by moving up the Moon landing. The Moon is the proving ground,” added the former Republican congressman, who was appointed by President Donald Trump.

NASA is racing to enact the plans of Trump, who dispatched Vice President Mike Pence to announce that the timetable for once again putting man on the Moon had been cut by four years to 2024.

The new date is politically significant: it would be the final year in Trump’s eventual second term at the White House.

Many experts and lawmakers are concerned that NASA cannot make the deadline, especially given the major delays in development of its new heavy-lift rocket, the Space Launch System, which is being built by aerospace giant Boeing.

Any mission to Mars would take at least two years, given the distance to be traveled. Getting there alone would take six months, as opposed to the three days needed to reach the Moon.

A round trip to Mars can only take place when the Red Planet is positioned on the same side of the Sun as Earth — that occurs about every 26 months, so the dates are 2031, 2033, and so on.

In 2017, a NASA budget bill set 2033 as the target date for the first manned mission to Mars, but NASA itself has talked about the “2030s” in its roadmap.

NASA wants to learn how to extract and use the tons of ice at the Moon’s south pole.

“Water ice represents air to breathe, it represents water to drink, it represents fuel,” Bridenstine said.

“The intent of course is to not just get humans to the surface of the Moon but prove that we can live and work on another world.”

Democratic lawmaker Eddie Bernice Johnson, the chair of the House Committee on Science, Space and Technology, asked Bridenstine to put a price tag on the new schedule.

The NASA chief said he would make his updated budget request by April 15.

 

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After the Moon in 2024, NASA Wants to Reach Mars by 2033

NASA has made it clear they want astronauts back on the Moon in 2024, and now, they are zeroing in on the Red Planet – the US space agency confirmed that it wants humans to reach Mars by 2033.

Jim Bridenstine, NASA’s administrator, said Tuesday that in order to achieve that goal, other parts of the program – including a lunar landing – need to move forward more quickly.

“We want to achieve a Mars landing in 2033,” Bridenstine told lawmakers at a congressional hearing on Capitol Hill.

“We can move up the Mars landing by moving up the Moon landing. The Moon is the proving ground,” added the former Republican congressman, who was appointed by President Donald Trump.

NASA is racing to enact the plans of Trump, who dispatched Vice President Mike Pence to announce that the timetable for once again putting man on the Moon had been cut by four years to 2024.

The new date is politically significant: it would be the final year in Trump’s eventual second term at the White House.

Many experts and lawmakers are concerned that NASA cannot make the deadline, especially given the major delays in development of its new heavy-lift rocket, the Space Launch System, which is being built by aerospace giant Boeing.

Any mission to Mars would take at least two years, given the distance to be traveled. Getting there alone would take six months, as opposed to the three days needed to reach the Moon.

A round trip to Mars can only take place when the Red Planet is positioned on the same side of the Sun as Earth — that occurs about every 26 months, so the dates are 2031, 2033, and so on.

In 2017, a NASA budget bill set 2033 as the target date for the first manned mission to Mars, but NASA itself has talked about the “2030s” in its roadmap.

NASA wants to learn how to extract and use the tons of ice at the Moon’s south pole.

“Water ice represents air to breathe, it represents water to drink, it represents fuel,” Bridenstine said.

“The intent of course is to not just get humans to the surface of the Moon but prove that we can live and work on another world.”

Democratic lawmaker Eddie Bernice Johnson, the chair of the House Committee on Science, Space and Technology, asked Bridenstine to put a price tag on the new schedule.

The NASA chief said he would make his updated budget request by April 15.

 

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US Health Officials Alarmed by Paralyzing Illness in Kids

One morning last fall, 4-year-old Joey Wilcox woke up with the left side of his face drooping.

It was the first sign of an unfolding nightmare.

Three days later, Joey was in a hospital intensive care unit, unable to move his arms or legs or sit up. Spinal taps and other tests failed to find a cause. Doctors worried he was about to lose the ability to breathe.

“It’s devastating,” said his father, Jeremy Wilcox, of Herndon, Virginia. “Your healthy child can catch a cold — and then become paralyzed.”

Joey, who survived but still suffers some of the effects, was one of 228 confirmed victims in the U.S. last year of acute flaccid myelitis, or AFM, a rare, mysterious and sometimes deadly paralyzing illness that seems to ebb and flow on an every-other-year cycle and is beginning to alarm public health officials because it is striking more and more children.

Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, said it may bear similarities to polio, which smoldered among humans for centuries before it exploded into fearsome epidemics in the 19th and 20th centuries.

Fauci, who published a report about the disease Tuesday in the journal mBio, said it is unlikely AFM will become as bad as polio, which struck tens of thousands of U.S. children annually before a vaccine became available in the 1950s.

But he warned: “Don’t assume that it’s going to stay at a couple of hundred cases every other year.”

While other countries have reported cases, including Canada, France, Britain and Norway, the size and pattern of the U.S. outbreaks have been more pronounced. More than 550 Americans have been struck this decade. The oldest was 32. More than 90% were children, most around 4, 5 or 6 years old.

Most had a cold-like illness and fever, seemed to get over it, then descended into paralysis. In some cases, it started in small ways — for example, a thumb that suddenly wouldn’t move. Some went on to lose the ability to eat or draw breath.

Many families say their children have regained at least some movement in affected limbs, but stories of complete recovery are unusual. Health officials cannot say how many recovered completely, partly or not at all, or how many have died, though the Centers for Disease Control and Prevention says deaths are rare.

Scientists suspect the illness is being caused chiefly by a certain virus that was identified more than 55 years ago and may have mutated to become more dangerous. But they have yet to prove that.

Treatments, physical therapy

And while doctors have deployed a number of treatments singly or in combination — steroids, antiviral medications, antibiotics, a blood-cleansing process — the CDC says there is no clear evidence they work.

Many parents say that when they first brought their child to the emergency room, they quickly realized to their horror that the doctors were at sea, too.

“Everyone is desperate for some magical thing,” said Rachel Scott, a Tomball, Texas, woman whose son Braden developed AFM in 2016 and has recovered somewhat after intensive physical therapy but still cannot move his right arm and has trouble swallowing and moving his neck.

A growing number of experts agree that physical therapy makes a difference.

“These kids can continue to recover very slowly, year over year. … It’s driven by how much therapy they do,” said Dr. Benjamin Greenberg of UT Southwestern Medical Center in Dallas, one of the nation’s foremost experts on the condition.

Wilcox, Joey’s father, said his son made huge improvements that way. Joey can run and use his arms. Still, muscle tone is weak in his right leg and shoulder, and he still has left-side facial paralysis. “He can’t completely smile,” his dad said.

Other stories are more tragic.

Katie Bustamante’s son Alex developed AFM in 2016. The suburban Sacramento, California, mother realized something was wrong when she asked the boy, then 5, why he wasn’t eating his yogurt. Alex replied that his thumb had stopped working and he couldn’t hold his spoon.

That morning was the start of 17 months of hospital stays, surgeries, therapy, and struggles with doctors and insurers to find a way to restore his ability to breathe. It ended one morning last May, when Alex died of complications.

Government officials need to step up, Bustamante said.

“I want them to research it and find the cause, and I want them to find a way to prevent it,” she said. “This is growing. This shouldn’t be happening.”

Suspected cause

More and more experts feel certain the main culprit is an enterovirus called EV-D68, based on the way waves of AFM have coincided with spikes of respiratory illnesses caused by EV-D68. Enteroviruses are a large family of viruses, some of which, such as polio, can damage the central nervous system, while many others cause mild symptoms or none at all.

In the U.S., doctors began reporting respiratory illnesses tied to EV-D68 in 1987, though usually no more than a dozen in any given year.

Then, in what may have been one of the first signs of the AFM waves to come, a 5-year-old boy in New Hampshire died in 2008 after developing neck tenderness and fever, then weakened arms and deadened legs. The boy had EV-D68, and in a report published in an obscure medical journal, researchers attributed his death to the virus.

The first real burst of AFM cases hit in 2014, when 120 were confirmed, with the largest concentrations in California and Colorado.

What ensued was an even-year, odd-year pattern: Cases dropped to 22 in 2015, jumped to 149 in 2016, and fell again, to 35 in 2017. Last year they reached 228, a number that may grow because scores of illnesses are still being investigated.

In keeping with the cyclical pattern, just four cases have been confirmed this year so far.

CDC officials consider an illness AFM based on scans and other evidence showing a certain kind of damage to the spinal cord. Proof of an enterovirus infection is not required for a case to be counted, mainly because such evidence has been hard to come by. So far, CDC investigators have been able to find evidence of enteroviruses in the spinal fluid of only four of 558 confirmed cases.

Scientists are using more sensitive spinal-fluid tests in hopes of establishing the connection between AFM and EV-D68 more firmly. That, in turn, could spur more focused work on treatments and maybe even a vaccine.

Meanwhile, Fauci’s agency has put out a call for researchers to apply for federal funds, and is tapping a University of Alabama-anchored network of pediatric research centers to work on the illness.

The CDC is pledging a greater focus, too. Parents have accused the agency of doing little more than counting cases and have complained that when they tried to contact CDC, they encountered only automated phone trees and form responses.

CDC officials have begun holding meetings and calls with families, set up a scientific task force and working to monitor cases more closely.

Fauci suggested it would be a mistake to assume that surges will take place every other year forever. The next one “may be in 2019, for all we know,” he said.

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US Health Officials Alarmed by Paralyzing Illness in Kids

One morning last fall, 4-year-old Joey Wilcox woke up with the left side of his face drooping.

It was the first sign of an unfolding nightmare.

Three days later, Joey was in a hospital intensive care unit, unable to move his arms or legs or sit up. Spinal taps and other tests failed to find a cause. Doctors worried he was about to lose the ability to breathe.

“It’s devastating,” said his father, Jeremy Wilcox, of Herndon, Virginia. “Your healthy child can catch a cold — and then become paralyzed.”

Joey, who survived but still suffers some of the effects, was one of 228 confirmed victims in the U.S. last year of acute flaccid myelitis, or AFM, a rare, mysterious and sometimes deadly paralyzing illness that seems to ebb and flow on an every-other-year cycle and is beginning to alarm public health officials because it is striking more and more children.

Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, said it may bear similarities to polio, which smoldered among humans for centuries before it exploded into fearsome epidemics in the 19th and 20th centuries.

Fauci, who published a report about the disease Tuesday in the journal mBio, said it is unlikely AFM will become as bad as polio, which struck tens of thousands of U.S. children annually before a vaccine became available in the 1950s.

But he warned: “Don’t assume that it’s going to stay at a couple of hundred cases every other year.”

While other countries have reported cases, including Canada, France, Britain and Norway, the size and pattern of the U.S. outbreaks have been more pronounced. More than 550 Americans have been struck this decade. The oldest was 32. More than 90% were children, most around 4, 5 or 6 years old.

Most had a cold-like illness and fever, seemed to get over it, then descended into paralysis. In some cases, it started in small ways — for example, a thumb that suddenly wouldn’t move. Some went on to lose the ability to eat or draw breath.

Many families say their children have regained at least some movement in affected limbs, but stories of complete recovery are unusual. Health officials cannot say how many recovered completely, partly or not at all, or how many have died, though the Centers for Disease Control and Prevention says deaths are rare.

Scientists suspect the illness is being caused chiefly by a certain virus that was identified more than 55 years ago and may have mutated to become more dangerous. But they have yet to prove that.

Treatments, physical therapy

And while doctors have deployed a number of treatments singly or in combination — steroids, antiviral medications, antibiotics, a blood-cleansing process — the CDC says there is no clear evidence they work.

Many parents say that when they first brought their child to the emergency room, they quickly realized to their horror that the doctors were at sea, too.

“Everyone is desperate for some magical thing,” said Rachel Scott, a Tomball, Texas, woman whose son Braden developed AFM in 2016 and has recovered somewhat after intensive physical therapy but still cannot move his right arm and has trouble swallowing and moving his neck.

A growing number of experts agree that physical therapy makes a difference.

“These kids can continue to recover very slowly, year over year. … It’s driven by how much therapy they do,” said Dr. Benjamin Greenberg of UT Southwestern Medical Center in Dallas, one of the nation’s foremost experts on the condition.

Wilcox, Joey’s father, said his son made huge improvements that way. Joey can run and use his arms. Still, muscle tone is weak in his right leg and shoulder, and he still has left-side facial paralysis. “He can’t completely smile,” his dad said.

Other stories are more tragic.

Katie Bustamante’s son Alex developed AFM in 2016. The suburban Sacramento, California, mother realized something was wrong when she asked the boy, then 5, why he wasn’t eating his yogurt. Alex replied that his thumb had stopped working and he couldn’t hold his spoon.

That morning was the start of 17 months of hospital stays, surgeries, therapy, and struggles with doctors and insurers to find a way to restore his ability to breathe. It ended one morning last May, when Alex died of complications.

Government officials need to step up, Bustamante said.

“I want them to research it and find the cause, and I want them to find a way to prevent it,” she said. “This is growing. This shouldn’t be happening.”

Suspected cause

More and more experts feel certain the main culprit is an enterovirus called EV-D68, based on the way waves of AFM have coincided with spikes of respiratory illnesses caused by EV-D68. Enteroviruses are a large family of viruses, some of which, such as polio, can damage the central nervous system, while many others cause mild symptoms or none at all.

In the U.S., doctors began reporting respiratory illnesses tied to EV-D68 in 1987, though usually no more than a dozen in any given year.

Then, in what may have been one of the first signs of the AFM waves to come, a 5-year-old boy in New Hampshire died in 2008 after developing neck tenderness and fever, then weakened arms and deadened legs. The boy had EV-D68, and in a report published in an obscure medical journal, researchers attributed his death to the virus.

The first real burst of AFM cases hit in 2014, when 120 were confirmed, with the largest concentrations in California and Colorado.

What ensued was an even-year, odd-year pattern: Cases dropped to 22 in 2015, jumped to 149 in 2016, and fell again, to 35 in 2017. Last year they reached 228, a number that may grow because scores of illnesses are still being investigated.

In keeping with the cyclical pattern, just four cases have been confirmed this year so far.

CDC officials consider an illness AFM based on scans and other evidence showing a certain kind of damage to the spinal cord. Proof of an enterovirus infection is not required for a case to be counted, mainly because such evidence has been hard to come by. So far, CDC investigators have been able to find evidence of enteroviruses in the spinal fluid of only four of 558 confirmed cases.

Scientists are using more sensitive spinal-fluid tests in hopes of establishing the connection between AFM and EV-D68 more firmly. That, in turn, could spur more focused work on treatments and maybe even a vaccine.

Meanwhile, Fauci’s agency has put out a call for researchers to apply for federal funds, and is tapping a University of Alabama-anchored network of pediatric research centers to work on the illness.

The CDC is pledging a greater focus, too. Parents have accused the agency of doing little more than counting cases and have complained that when they tried to contact CDC, they encountered only automated phone trees and form responses.

CDC officials have begun holding meetings and calls with families, set up a scientific task force and working to monitor cases more closely.

Fauci suggested it would be a mistake to assume that surges will take place every other year forever. The next one “may be in 2019, for all we know,” he said.

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Scam Ads Promoting Fake Tax Breaks Prosper on Facebook

Hundreds of ads on Facebook promised U.S. homeowners that they were eligible for huge state tax breaks if they installed new solar-energy panels. There was just one catch: None of it was true.

 

The scam ads used photos of nearly every U.S. governor — and sometimes President Donald Trump — to claim that with new, lucrative tax incentives, people might actually make money by installing solar technology on their homes. Facebook users only needed to enter their addresses, email, utility information and phone number to find out more.

 

Those incentives don’t exist.

 

While the ads didn’t aim to bilk people of money directly — and it wasn’t possible to buy solar panels through these ads — they led to websites that harvested personal information that could be used to expose respondents to future come-ons, both scammy and legitimate. It’s not clear that the data was actually used in such a manner.

 

Facebook apparently didn’t take action until notified by state-government officials who noticed the ads.

 

The fictitious notices reveal how easily scammers can pelt internet users with misinformation for months, undetected. They also raise further questions about whether big tech companies such as Facebook are capable of policing misleading ads, especially as the 2020 elections — and the prospect of another onslaught of online misinformation — loom.

 

“This is definitely concerning — definitely, it’s misinformation,” said Young Mie Kim, a University of Wisconsin-Madison professor who studied 5 million Facebook ads during the 2016 elections. “I keep telling people: We don’t have any basis to regulate such a thing.”

 

Experts say websites and apps need to be more transparent about the ads that run on their platforms.

 

Last year, Facebook launched a searchable database that provides details on political ads it runs, including who bought them and the age and gender of the audience. But it doesn’t make that information available for other ads. Twitter offers its own database of ads and promoted tweets. Google has an archive for political ads only.

 

The partial approaches allow misleading ads to fester. One problem is the fact that ads can be targeted so narrowly that journalists and watchdog groups often won’t see them.

 

“That allows people to do more dirty tricks,” said Ian Vanderwalker, senior counsel at the Brennan Center for Justice’s Democracy Program.

 

In mid-March, some websites linked in the fake solar-energy ads disappeared. After complaints from governors’ offices, Facebook inactivated nearly all of the ads and several pages affiliated with them.

 

“These scammy ads have no place on Facebook,” company spokeswoman Devon Kearns said in a statement. “We removed these pages and disabled these ad accounts recently and will continue to take action.”

 

Facebook says it uses an automated process to review the images, text, targeting and position of ads posted to its site. In some cases, employees review the ads. Users can also give feedback if they believe the ads violate company policies.

 

Governors’ offices were alarmed to see photos of top politicians featured alongside claims such as “you can get paid to go solar.”  

 

Helen Kalla, a spokeswoman for Nevada Gov. Steve Sisolak, said she notified Facebook last month after staffers saw them.

 

Facebook took them down days later, although some continued to re-appear days after that complaint. Facebook also yanked ads featuring images of governors in Texas, Illinois, Colorado, Arizona, South Carolina and other states. But the ads had already been running for some time.

 

After researching solar-panel options for his two-story home in Mount Tabor, New Jersey, 37-year-old Chris Fitzpatrick saw an ad claiming he might qualify for “free” solar panels because Gov. Phil Murphy planned to release “$100 million solar incentives.” He was skeptical because none of the solar companies he worked with mentioned such incentives, but worried others might not be.

 

“It’s very frustrating because it preys upon innocent people,” Fitzpatrick said.

 

The Associated Press found that some of these ads directed people to solar-energy websites that listed the same business address — a mailbox in Carlsbad, California — that had been used by a company once under investigation by the Federal Trade Commission, the government’s consumer protection agency. In 2012, the FTC sued Jason Akatiff and his company — then called Coleadium, also known as Ads 4 Dough — for running fake news websites that marketed unfounded health benefits of colon cleanse and acai berry products, according to court records.

 

Akatiff settled the allegations without admitting guilt and agreed to a $1 million fine. Akatiff changed his company’s name to A4D Inc. in 2015, according to California business filings.

 

Akatiff did not respond to messages left with his California business.  

 

Though the FTC can investigate fake ads, sue to stop them and seek compensation for victims, thousands of ads targeting select groups run online daily, making it harder to catch suspect advertisers.  

 

Scam ads are popular in certain industries, such as insurance or solar power, where companies are looking for people they can target later for products and services, said Peter Marinello, vice president of the Council of Better Business Bureaus Inc.

 

The scammers sell the personal information they collect to other companies looking for potential customers, Marinello said. “That’s how this whole process plays out.”

 

 

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Insecurity, Community Mistrust Stymie Efforts to Control DRC Ebola Epidemic

The World Health Organization says insecurity and community mistrust in the Democratic Republic of Congo’s conflict-ridden North Kivu Province are major impediments to international health efforts to bring the deadly Ebola outbreak under control. Latest official figures put the number of Ebola cases in the Eastern DRC at 1,089, including 679 deaths.

The World Health Organization reports an increase in the number of Ebola cases. Last week, it says there were 72 recorded cases compared to 56 cases of the deadly disease the week before.

WHO Assistant Director-General for Emergencies Response Ibrahima-Soce Fall attributes the rise to insecurity and violence in the North Kivu hot spots of Butembo and Katwa. He says that has caused major disruptions in the ability of health workers to respond to the disease.

As a consequence, he says people in contact with infected individuals are unprotected. He says contacts cannot get vaccinated or be followed for signs of illness. He says burials are not conducted safely, resulting in some mourners becoming infected.

Speaking on a phone line from Butembo, Fall says the difficulty of getting people to understand that Ebola is a problem further complicates the situation.

“There are so many other problems like insecurity, being killed for many years, access to water, education and so on. So, it takes time to convince them that Ebola is the real problem for them,” he said. “And that is why we have started this community dialogue — to listen to them, to understand their problems and working with diplomatic partners, like World Bank and UNICEF to address the other problems they have been having for many, many years.”

As part of this outreach program, Fall says 40 young people from the local communities have been trained and are now part of the burial and disinfection team. He says the response to this and other measures requested by the community are beginning to have a positive impact.

The WHO estimates it will take at least six months before it gains control of the Ebola outbreak. It says it expects cases will continue to increase until full response measures can be put in place in all vulnerable areas.

 

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Factbox: A look at NATO

NATO foreign ministers are gathering in Washington, D.C. this week to celebrate the 70th anniversary of the North Atlantic Treaty Organization. U.S. President Donald Trump has been critical of other alliance members for under-investing on defense and relying too heavily on the United States. 

We take a look at the alliance. 

What is NATO?

The North Atlantic Treaty Organization is an alliance of 29 countries bordering the North Atlantic Ocean. It was created in 1949 as a bulwark against the Soviet Union. Its purpose is to “guarantee the freedom and security of its members through political and military means,” according to its website. 

Who are the members? 

The initial alliance was entered into by 12 nations, including the United States, Britain, Belgium, Canada, Denmark, France, Iceland, Italy, Luxembourg, the Netherlands, Norway and Portugal. Seventeen others have joined the group since. Montenegro is the latest member, joining in 2017. According to Article 10 of the Washington Treaty, membership is open to any “European State in a position to further the principles of this Treaty and to contribute to the security of the North Atlantic area.”

What is its aim? 

NATO’s main aim is security and defense of its member nations. Article 5 of the treaty states that “an armed attack against one or more” member state “shall be considered an attack against them all.”

The collective defense principal at the heart of the treaty was invoked for the first time after the 9/11 attacks on the United States. NATO responded to a U.S. request for help in the war on al-Qaida in Afghanistan. It took the lead from August 2003 to December 2014. At its peak, it deployed 130,000 troops.

Who funds NATO? 

Each member country pays a certain amount into the NATO budget based on an agreed upon formula. But, the United States has been bearing nearly two-thirds of the alliance’s defense bill. The NATO charter requires member states to spend 2 percent of the nation’s wealth on defense. According to NATO’s most recent estimate, released in June 2017, six countries hit the 2 percent target: the United States, Greece, the United Kingdom, Estonia, Romania and Poland.

NATO vs. Trump

President Donald Trump has long been critical of U.S. involvement overseas. He has specifically railed against NATO members for not contributing more money to their own defense. In July, he went so far as to claim that the alliance owed the United States money.

“Many countries owe us a tremendous amount of money from many years back, where they’re delinquent, as far as I’m concerned, because the United States has had to pay for them,” he said. “So if you go back 10 or 20 years, you’ll just add it all up, it’s massive amounts of money is owed.”

But that is not how the alliance’s budget works. While not all member states are meeting their commitments, as explained above, more are expected to increase their contributions this year.

Trump has also threatened to pull out of the treaty, which experts say would be a monumental mistake.

The celebration of NATO’s 70th anniversary was downgraded to a meeting of member foreign ministers, because diplomats feared Trump would use the occasion to mount renewed attacks on the alliance. Trump is not expected to address the meeting in Washington this week. 

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Factbox: A look at NATO

NATO foreign ministers are gathering in Washington, D.C. this week to celebrate the 70th anniversary of the North Atlantic Treaty Organization. U.S. President Donald Trump has been critical of other alliance members for under-investing on defense and relying too heavily on the United States. 

We take a look at the alliance. 

What is NATO?

The North Atlantic Treaty Organization is an alliance of 29 countries bordering the North Atlantic Ocean. It was created in 1949 as a bulwark against the Soviet Union. Its purpose is to “guarantee the freedom and security of its members through political and military means,” according to its website. 

Who are the members? 

The initial alliance was entered into by 12 nations, including the United States, Britain, Belgium, Canada, Denmark, France, Iceland, Italy, Luxembourg, the Netherlands, Norway and Portugal. Seventeen others have joined the group since. Montenegro is the latest member, joining in 2017. According to Article 10 of the Washington Treaty, membership is open to any “European State in a position to further the principles of this Treaty and to contribute to the security of the North Atlantic area.”

What is its aim? 

NATO’s main aim is security and defense of its member nations. Article 5 of the treaty states that “an armed attack against one or more” member state “shall be considered an attack against them all.”

The collective defense principal at the heart of the treaty was invoked for the first time after the 9/11 attacks on the United States. NATO responded to a U.S. request for help in the war on al-Qaida in Afghanistan. It took the lead from August 2003 to December 2014. At its peak, it deployed 130,000 troops.

Who funds NATO? 

Each member country pays a certain amount into the NATO budget based on an agreed upon formula. But, the United States has been bearing nearly two-thirds of the alliance’s defense bill. The NATO charter requires member states to spend 2 percent of the nation’s wealth on defense. According to NATO’s most recent estimate, released in June 2017, six countries hit the 2 percent target: the United States, Greece, the United Kingdom, Estonia, Romania and Poland.

NATO vs. Trump

President Donald Trump has long been critical of U.S. involvement overseas. He has specifically railed against NATO members for not contributing more money to their own defense. In July, he went so far as to claim that the alliance owed the United States money.

“Many countries owe us a tremendous amount of money from many years back, where they’re delinquent, as far as I’m concerned, because the United States has had to pay for them,” he said. “So if you go back 10 or 20 years, you’ll just add it all up, it’s massive amounts of money is owed.”

But that is not how the alliance’s budget works. While not all member states are meeting their commitments, as explained above, more are expected to increase their contributions this year.

Trump has also threatened to pull out of the treaty, which experts say would be a monumental mistake.

The celebration of NATO’s 70th anniversary was downgraded to a meeting of member foreign ministers, because diplomats feared Trump would use the occasion to mount renewed attacks on the alliance. Trump is not expected to address the meeting in Washington this week. 

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Meatless Burgers Go Mainstream

Vegetarian patties have long been available to Americans seeking healthier alternatives to hamburgers. Mainstream fast food chains also have been looking for healthier alternatives that would not compromise on flavor. Burger King teamed with California-based Impossible Foods to create a meatless hamburger that would taste as good as its world famous Whopper. The new meatless option was rolled out in 59 Burger King restaurants in the St. Louis, Missouri, area. VOA’s Zlatica Hoke reports.

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Meatless Burgers Go Mainstream

Vegetarian patties have long been available to Americans seeking healthier alternatives to hamburgers. Mainstream fast food chains also have been looking for healthier alternatives that would not compromise on flavor. Burger King teamed with California-based Impossible Foods to create a meatless hamburger that would taste as good as its world famous Whopper. The new meatless option was rolled out in 59 Burger King restaurants in the St. Louis, Missouri, area. VOA’s Zlatica Hoke reports.

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Facebook, Rights Groups Hit Out at Singapore’s Fake News Bill

Singapore submitted wide-ranging fake news legislation in parliament on Monday, stoking fears from internet firms and human rights groups that it may give the government too much power and hinder freedom of speech.

The law would require social media sites like Facebook to carry warnings on posts the government deems false and remove comments against “public interest.”

The move came two days after Facebook founder Mark Zuckerberg said governments should play a more active role in regulating the online platform.

But Simon Milner, who works on Facebook’s public policy in Asia, said after the law was tabled, the firm was “concerned with aspects of the law that grant broad powers to the Singapore executive branch to compel us to remove content they deem to be false and proactively push a government notification to users.”

“As the most far-reaching legislation of its kind to date, this level of overreach poses significant risks to freedom of expression and speech, and could have severe ramifications both in Singapore and around the world,” said Jeff Paine, managing director of the Asia Internet Coalition, an industry association of internet and technology companies in the region.

Speaking to reporters on Monday, Singapore’s Law Minister K. Shanmugam said the new legislation would not hinder free speech.

“This legislation deals with false statements of facts. It doesn’t deal with opinions, it doesn’t deal with viewpoints. You can have whatever viewpoints however reasonable or unreasonable,” he said.

Tech giants Facebook, Twitter and Google all have their Asia headquarters in the city-state, a low-tax finance hub seen as a island of stability in the middle of the fast-growing but often-turbulent Southeast Asia region.

“Malicious actors”

Singapore, which has been run by the same political party since independence from Britain more than 50 years ago, says it is vulnerable to fake news because of its position as a global financial hub, its mixed ethnic and religious population and widespread internet access.

It is ranked 151 among 180 countries rated in the World Press Freedom Index of Reporters Without Borders, a non-government group that promotes freedom of information, below the likes of Russia and Myanmar.

The new bill proposes that the government get online platforms to publish warnings or “corrections” alongside posts carrying false information, without removing them.

This would be the “primary response” to counter falsehoods online, the Law Ministry said.

“That way, in a sense, people can read whatever they want and make up their minds. That is our preference,” Law Minister K. Shanmugam told reporters on Monday.

Under the proposals, which must be approved by parliament, criminal sanctions including hefty fines and jail terms will be imposed if the falsehoods are spread by “malicious actors” who “undermine society”, the ministry said, without elaborating.

It added that it would cut off an online site’s “ability to profit”, without shutting it down, if the site had published three falsehoods that were “against the public interest” over the previous six months.

It did not say how it would block a site’s profit streams.

The bill came amid talk of a possible general election this year. Law Minister Shanmugam declined to comment when asked if the new legislation was related to a vote.

“This draft law will be a disaster for human rights, particularly freedom of expression and media freedom,” said Phil Robertson, deputy director, Asia division, at Human Rights Watch.

“The definitions in the law are broad and poorly defined, leaving maximum regulatory discretion to the government officers skewed to view as “misleading” or “false” the sorts of news that challenge Singapore’s preferred political narratives.”

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Your Body: The Network You Didn’t Know You Had

Networks like Bluetooth connect our devices easily and effortlessly. But the area that these portable networks cover is big enough to make them hackable. Now, a group of engineers from Purdue has solved that problem by turning your body into a network. Kevin Enochs explains.

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