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Australian researchers say enzyme could help lower lower CO2

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SYDNEY — Australian scientists say they have discovered how an enzyme “hidden in nature’s blueprint” could help develop climate-resilient crops able to remove more carbon dioxide from the atmosphere. 

An Australian study, by researchers from Australian National University and the University of Newcastle in New South Wales, focuses on a type of bacteria researchers call “tiny carbon superheroes.” 

Cyanobacteria, a type of algae-like bacteria also called blue-green algae, are found in fresh and coastal waters, as well as oceans.  They are commonly known for their toxic blooms in lakes and rivers.  

Through the process of photosynthesis, Australian scientists say, they capture about 12% of the world’s carbon dioxide each year. 

Their study says a carbon dioxide-concentrating mechanism in cyanobacteria lets them turn atmospheric carbon dioxide into sugars for cells to eat more quickly than most standard plants and crops.

Until now, the Australian team was unaware how critical an enzyme in cyanobacteria, called carboxysomal carbonic anhydrase, was to the process. The study says the mystery of how the enzyme maximizes the cyanobacteria’s ability to extract atmospheric carbon dioxide has been solved.

Ben Long, a senior lecturer in molecular plant biology at Australia’s University of Newcastle and is the study’s lead author.

He told VOA that the aim is to engineer crops that can absorb more greenhouse gases.   

“We are actually interested in utilizing this CO2-concentrating mechanism from cyanobacteria, which we know is a remarkably efficiently system for capturing CO2 and we want to engineer that into plant cells to make plant cells able to capture CO2 far more effectively and efficiently,” Long said.

The research says that engineered plants that are more efficient at capturing carbon dioxide could increase crop yield, making global food systems that are more resilient to climate change. 

Long says the findings should be part of international efforts to reduce greenhouse gases.  

“Every technology has to be brought to bear to try to reduce CO2 emissions and reduce CO2 in the atmosphere and I think to date we have not really focused much on those potential biological applications to reduce greenhouse gas emissions,” Long said.

The study has been published in the journal Science Advances.
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Kenya conference showcases technology to help people with disabilities

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In Africa, about 15% of the population faces disability challenges despite advancements in technology. Limited infrastructure and high cost of assistive tech create barriers to digital access, leading to exclusion. A conference in Nairobi this week aims to help change that. Mohammed Yusuf reports.
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Webb telescope uncovers merger of two massive black holes from early universe

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CAPE CANAVERAL, FLORIDA — The Webb Space Telescope has discovered the earliest known merger of black holes.

These two gigantic black holes and their galaxies consolidated just 740 million years after the universe-forming Big Bang. It’s the most distant detection ever made of merging black holes, scientists reported Thursday.

One black hole is 50 million times more massive than our sun. The other is thought to be similar in size, but is buried in dense gas, which makes it harder to measure.

Until now, astronomers weren’t sure how supermassive black holes got so big.

The latest findings, published in the Monthly Notices of the Royal Astronomical Society, suggest mergers are how black holes can grow so rapidly — “even at cosmic dawn,” said lead author Hannah Ubler of the University of Cambridge.

“Massive black holes have been shaping the evolution of galaxies from the very beginning,” Ubler said in a statement.

Launched in 2021 as the eventual successor to NASA’s Hubble Space Telescope, Webb is the biggest and most powerful observatory ever sent into space. A joint U.S.-European project, the infrared observatory surveys the universe from a location 1.6 million kilometers from Earth.
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Fewer US overdose deaths reported last year, but experts still cautious

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NEW YORK — The number of fatal overdoses in the U.S. fell last year, according to Centers for Disease Control and Prevention data posted Wednesday.

Agency officials noted that the data is provisional and could change after more analysis, and that they still expect a drop when the final counts are in. It would be only the second annual decline since the current national drug death epidemic began more than three decades ago.

Experts reacted cautiously. One described the decline as relatively small and said it should be thought of as part of a leveling off rather than a decrease. Another noted that the last time a decline occurred — in 2018 — drug deaths shot up in the years that followed.

“Any decline is encouraging,” said Brandon Marshall, a Brown University researcher who studies overdose trends. “But I think it’s certainly premature to celebrate or to draw any large-scale conclusions about where we may be headed long term with this crisis.”

It’s also too soon to know what spurred the decline, Marshall and other experts said. Explanations could include shifts in the drug supply, expansion of overdose prevention and addiction treatment, and the grim possibility that the epidemic has killed so many that now there are basically fewer people to kill.

CDC Chief Medical Officer Dr. Debra Houry called the dip “heartening news” and praised efforts to reduce the tally, but she noted that “there are still families and friends losing their loved ones to drug overdoses at staggering numbers.”

About 107,500 people died of overdoses in the U.S. last year, including American citizens and noncitizens who were in the country at the time they died, the CDC estimated. That’s down 3% from 2022, when there were an estimated 111,000 such deaths, the agency said.

The drug overdose epidemic, which has killed more than 1 million people since 1999, has had many ripple effects. For example, a study published last week in JAMA Psychiatry estimated that more than 321,000 U.S. children lost a parent to a fatal drug overdose from 2011 to 2021.

“These children need support” and are at a higher risk of mental health and drug use disorders themselves, said Dr. Nora Volkow, director of the National Institute on Drug Abuse, which helped lead the study. “It’s not just a loss of a person. It’s also the implications that loss has for the family left behind.”

Prescription painkillers once drove the nation’s overdose epidemic, but they were supplanted years ago by heroin and more recently by illegal fentanyl. The dangerously powerful opioid was developed to treat intense pain from ailments such as cancer but has increasingly been mixed with other drugs in the illicit drug supply.

For years, fentanyl was frequently injected, but increasingly it’s being smoked or mixed into counterfeit pills.

A study published last week found that law enforcement seizures of pills containing fentanyl are rising dramatically, jumping from 44 million in 2022 to more than 115 million last year.

It’s possible that the seizures indicate that the overall supply of fentanyl-laced pills is growing fast, not necessarily that police are whittling down the illicit drug supply, said one of the paper’s authors, Dr. Daniel Ciccarone of the University of California, San Francisco.

He noted that the decline in overdoses was not uniform. All but two of the states in the eastern half of the U.S. saw declines, but most Western states saw increases. Alaska, Washington and Oregon each saw 27% increases.

The reason? Many Eastern states have been dealing with fentanyl for about a decade, while it’s reached Western states more recently, Ciccarone said.

Nevertheless, some researchers say there are reasons to be optimistic. It’s possible that smoking fentanyl is not as lethal as injecting it, but scientists are still exploring that question.

Meanwhile, more money is becoming available to treat addiction and prevent overdoses, through government funding and legal settlements with drugmakers, wholesalers and pharmacies, Ciccarone noted.

“My hope is 2023 is the beginning of a turning point,” he said. 
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Old Hollywood glamour sizzles at National Portrait Gallery exhibit

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He captured the most famous faces in 1930s and early ’40s cinema — Garbo, Crawford, Bogart and Gable. Now the work of George Hurrell, one of Hollywood’s greatest portrait photographers, is on display at Washington’s National Portrait Gallery. For VOA News, Cristina Caicedo Smit has the story. Videographer: Hakim Shammo; Video editor: Cristina Caicedo Smit
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Miniature poodle Sage fetches top prize at Westminster Kennel Club Dog Show 

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NEW YORK — A sprightly miniature poodle named Sage was crowned “Best in Show” on Tuesday at the 148th annual Westminster Kennel Club Dog Show, winning the grand prize in the most prestigious competition among pure-bred canines in the United States.

Sage, the finalist representing 21 breeds classified as non-sporting dogs, triumphed over more than 2,500 top-ranked dogs competing in the two-day contest, held at the USTA Billie Jean King National Tennis Center in the Queens borough of New York City.

Sage, a 4-year-old black-colored female groomed in the fine, fluffy topiary style traditional for poodles, competed head to head against the winners in six other groups — terriers, hounds, herding dogs, working dogs, sporting dogs and toy dogs.

She was the first female to win the top prize at Westminster since 2020, according to commentators on the Fox Sports channel, which broadcast the event live.

And she became the fourth miniature poodle to claim the top prize in the 148-year history of the contest, with the trophy previously going to her breed in 1943, 1959 and 2002, according to kennel club records.

The larger “standard” poodle breed has been declared Best in Show five times, most recently in 2020, and the smaller “toy” poodle breed has won twice.

The poodle originated as a hunting dog in Germany and is now recognized as the national dog of France.

Sage’s handler, Kaz Hosaka, cried tears of joy and carried his prized poodle in his arms around floor of the auditorium to cheers of the crowd as he celebrated what he said was his 45th year participating at the Westminster dog show and the last of his career.

The Westminster dog show bills itself as the second-oldest U.S. sporting event, behind only the Kentucky Derby thoroughbred horse race. This year’s competition drew a field of contenders representing 200 breeds from all 50 U.S. states and 12 other countries.

Mercedes, a female 4-year-old German shepherd, was named runner-up for the overall contest, after first winning the top prize in the herding dog group.

Along with Sage and Mercedes, the two other finalists chosen on Monday were Comet the Shih Tzu, representing the toy group, and Louis, the Afghan hound leading the hound group.

Rounding out the finalists were three group winners chosen on Tuesday – Micah the black cocker spaniel, representing sporting dogs; Monty, the giant schnauzer, leading the working dogs; and Frankie, a colored bull terrier from the terrier group.
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Alice Munro, Canadian Nobel Prize-winning author, dies at 92

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ottawa — Nobel Prize-winning Canadian writer Alice Munro, whose exquisitely crafted tales of the loves, ambitions and travails of small-town women in her native land made her a globally acclaimed master of the short story, has died at the age of 92, her publisher said on Tuesday. 

Munro died at her home in Port Hope, Ontario, said Kristin Cochrane, chief executive officer of McClelland & Stewart.  

“Alice’s writing inspired countless writers … and her work leaves an indelible mark on our literary landscape,” she said in a statement. 

The Globe and Mail newspaper, citing family members, said Munro had died on Monday after suffering from dementia for at least a decade. 

Munro published more than a dozen collections of short stories and was honored with the Nobel Prize in Literature in 2013. 

Her stories explored sex, yearning, discontent, aging, moral conflict and other themes in rural settings with which she was intimately familiar, the villages and farms in the Canadian province of Ontario. She was adept at fully developing complex characters within the limited pages of a short story. 

“Alice Munro was a Canadian literary icon. For six decades, her short stories captivated hearts around Canada and the world,” Canadian Heritage Minister Pascale St-Onge said on the X social media network. 

Munro, who wrote about ordinary people with clarity and realism, was often likened to Anton Chekhov, the 19th century Russian known for his brilliant short stories, a comparison the Swedish Academy cited in honoring her with the Nobel Prize. 

Calling her a “master of the contemporary short story,” the Academy also said: “Her texts often feature depictions of everyday but decisive events, epiphanies of a kind, that illuminate the surrounding story and let existential questions appear in a flash of lightning.” 

In an interview with the Canadian Broadcasting Corporation after winning the Nobel, Munro said, “I think my stories have gotten around quite remarkably for short stories, and I would really hope that this would make people see the short story as an important art, not just something that you played around with until you’d got a novel written.” 

Munro’s works included “Dance of the Happy Shades” (1968), “Lives of Girls and Women” (1971), “Who Do You Think You Are?” (1978), “The Moons of Jupiter” (1982), “Hateship, Friendship, Courtship, Loveship, Marriage” (2001), “Runaway” (2004), “The View from Castle Rock” (2006), “Too Much Happiness” (2009) and “Dear Life” (2012). 

The characters in her stories were often girls and women who lead seemingly unexceptional lives but struggle with tribulations ranging from sexual abuse and stifling marriages to repressed love and the ravages of aging. 

“Last month I reread all of Alice Munro’s books. I felt the need to be close to her. Every time I read her is a new experience. Every time changes me. She will live forever,” Canadian author Heather O’Neill said in a post on X. 

Munro’s story of a woman who starts losing her memory and agrees to enter a nursing home titled “The Bear Came Over the Mountain,” from “Hateship, Friendship, Courtship, Loveship, Marriage,” was adapted into the Oscar-nominated 2006 film “Away From Her,” directed by fellow Canadian Sarah Polley. 

‘Shame’ a driving force of characters 

Canadian novelist Margaret Atwood, writing in The Guardian after Munro won the Nobel, summarized her work by saying: “Shame and embarrassment are driving forces for Munro’s characters, just as perfectionism in the writing has been a driving force for her: getting it down, getting it right, but also the impossibility of that. Munro chronicles failure much more often than she chronicles success, because the task of the writer has failure built in.” 

American novelist Jonathan Franzen wrote in 2005, “Reading Munro puts me in that state of quiet reflection in which I think about my own life: about the decisions I’ve made, the things I’ve done and haven’t done, the kind of person I am, the prospect of death.” 

The short story, a style more popular in the 19th and early 20th century, has long taken a back seat to the novel in popular tastes and in attracting awards. But Munro was able to infuse her short stories with a richness of plot and depth of detail usually more characteristic of full-length novels. 

“For years and years, I thought that stories were just practice, ’til I got time to write a novel. Then I found that they were all I could do and so I faced that. I suppose that my trying to get so much into stories has been a compensation,” Munro told the New Yorker magazine in 2012. 

Second Canadian to win Nobel

Munro was the second Canadian-born writer to win the Nobel literature prize but the first with a distinctly Canadian identity. Saul Bellow, who won in 1976, was born in Quebec but raised in the U.S. city of Chicago, Illinois, and was widely seen as an American writer. 

Munro also won the Man Booker International Prize in 2009 and the Giller Prize — Canada’s most high-profile literary award — twice. 

Alice Laidlaw was born to a hard-pressed family of farmers on July 10, 1931, in Wingham, a small town in the region of southwestern Ontario that serves as the setting for many of her stories, and started writing in her teens. 

She married James Munro in 1951 and moved to Victoria, British Columbia, where the two ran a bookstore. They had four daughters, one died just hours old, before divorcing in 1972. Afterward, Munro moved back to Ontario. Her second husband, geographer Gerald Fremlin, died in April 2013. 
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Iranian director Rasoulof urges film world to support colleagues

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cannes, france — Film director Mohammad Rasoulof, who has secretly fled Iran for an undisclosed location in Europe, urged the world film community on Tuesday to provide “strong support” to his colleagues.

Rasoulof, who was sentenced to jail on national security charges, and whose latest movie will compete at this month’s Cannes film festival, said he fears for the “safety and well-being” of fellow filmmakers still in Iran.

“The global film community must provide strong support to the makers of these films,” Rasoulof said in a statement to Agence France-Presse.

Rasoulof announced on Monday he had escaped clandestinely from Iran, just days after it emerged that he had been sentenced to eight years in prison for “collusion against national security.”

Rasoulof had been under pressure from Iranian authorities to withdraw his latest film, “The Seed of the Sacred Fig,” from Cannes, where it will compete for the prestigious event’s top prize, the Palme d’Or.

Cannes director Thierry Fremaux said the festival was working with the French Foreign Ministry in the hope of ensuring that Rasoulof, 51, can attend his premiere next week.

Rasoulof’s statement said he did not yet know if he could attend the premiere.

“I arrived in Europe a few days ago after a long and complicated journey,” said Rasoulof, who won the Berlin International Film Festival’s Golden Bear in 2020 for “There Is No Evil.”

He said his latest movie set out to portray a version of Iran “that is far from the narrative dominated by censorship in the Islamic Republic and is closer to reality.”

After he and his filmmaking colleagues came under pressure from the authorities, Rasoulof learned that his “unfair” eight-year sentence would be enforced imminently, and he felt he had no choice but to flee.

“I had to choose between prison and leaving Iran,” he wrote. “With a heavy heart, I chose exile.”

While some colleagues involved in the film were also able to leave the country, others remain there.

“My thoughts go to every single one of them, and I fear for their safety and well-being,” he said.
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New TB vaccine being tested in South Africa holds hope for millions

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A groundbreaking clinical trial is underway in South Africa, marking a pivotal moment in the fight against tuberculosis. The new vaccine could become the first to help prevent pulmonary TB, the most common form of the disease, in adolescents and adults. It would be the first new TB vaccine in more than a century. Zaheer Cassim has the story.
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Dazzling auroras fade from skies as sunspot turns away

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Washington — The spectacular auroras that danced across the sky in many parts of the world over the weekend are fading, scientists said Monday, as the massive sunspot that caused them turns its ferocious gaze away from Earth.

Since Friday, the most powerful solar storm to strike our planet in more than two decades has lit up night skies with dazzling auroras in the United States, Tasmania, the Bahamas and other places far from the extreme latitudes where they are normally seen.

But Eric Lagadec, an astrophysicist at France’s Observatoire de la Cote d’Azur, told AFP that the “most spectacular” period of this rare event has come to an end.

The first of several coronal mass ejections (CMEs) — expulsions of plasma and magnetic fields from the Sun — came just after 1600 GMT Friday, according to the US-based National Oceanic and Atmospheric Administration (NOAA).

The event was later upgraded to an “extreme” geomagnetic storm — the first since the “Halloween Storms” of October 2003 that caused blackouts in Sweden and damaged power infrastructure in South Africa.

Excitement over the phenomenon — and otherworldly photos of pink, green and purple night skies — broke out across the world, from Austria to Australia’s island state of Tasmania.

The storm had been forecast to intensify again until 0600 GMT Monday, the NOAA said, adding that auroras could be viewable as far south as New York.

But thousands of people who came out on Sunday night in the hope of seeing the aurora borealis over the Joshua Tree National Park in California instead saw the Milky Way. AFP pictures showed stars shining clearly in the night sky.

Lagadec said that while there were further solar outbursts on Sunday, it is unlikely that more auroras will be visible to the naked eye in lower latitudes such as in France.

“Only the most experienced photographers will be able to capture them” in such areas, said Lagadec, who was moved by witnessing an aurora during the event’s peak on Friday night.

The solar storm emanated from a massive sunspot cluster that is 17 times wider than our planet.

The storm has not ended, and auroras are expected to continue in the far northern or southern regions where they are normally visible.

But “the source of the storm is a sunspot that is now on the edge of the Sun, (so) we do not expect the next coronal mass ejections to head in Earth’s direction,” Lagadec said.

Scientists had already warned that the intensity of anything seen on Sunday night would unlikely reach the level of Friday’s show.

“This is likely the last of the Earth-directed CMEs from this particular monster sunspot,” Mathew Owens, a professor of space physics at the UK’s University of Reading, told AFP.

When charged particles from solar winds are captured by Earth’s magnetic field, they accelerate towards the planet’s magnetic poles, which is why auroras are normally seen there.

But during periods of heightened solar activity, the effects extend farther toward the equator.

Unlike during 2003’s solar storms, no major disruptions to power or communications networks appear to have been reported this time around.

Elon Musk’s satellite internet operator Starlink said on X that its thousands of satellites in low Earth orbit had “weathered the geomagnetic storm and remain healthy”.

Unlike solar flares, which travel at the speed of light and reach Earth in around eight minutes, CMEs travel at a more sedate pace, with officials putting the current average at 800 kilometers (500 miles) per second.

People with eclipse glasses can still look for the sunspot cluster during the day.

Fluctuating magnetic fields associated with geomagnetic storms induce currents in long wires, including power lines, which can lead to blackouts. Long pipelines can also become electrified.

Spacecraft are at risk from high doses of radiation, although the atmosphere prevents this from reaching Earth.

NASA can ask astronauts on the International Space Station to move to better-shielded places within the outpost.

Even pigeons and other species that have internal biological compasses can be affected.
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‘Kingdom of the Planet of the Apes’ reigns at the box office with $56.5 million opening

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LOS ANGELES — “Kingdom of the Planet of the Apes” reigned over the weekend box office with a $56.5 million North American opening, according to studio estimates Sunday, giving a needed surge to an uncertain season in theaters.

The film from 20th Century Studios and Disney that built on the rebooted “Apes” trilogy of the 2010s had the third highest opening of the year, after the $81.5 million debut of “Dune: Part Two” in early March and the $58.3 million domestic opening of “Kung Fu Panda 4” a week later.

The strong performance for “Kingdom of the Planet of the Apes” — it played even better internationally with a global total of $129 million — comes a week after a tepid start for Ryan Gosling’s “The Fall Guy” signaled that the summer of 2024 is likely to see a major drop-off after the “Barbenheimer” magic of 2023.

“Planet of the Apes” easily made more than the rest of the top 10 combined.

“The Fall Guy” fell to No. 2 with a $13.7 million weekend and a two-week total of $49.7 million for Universal Pictures.

Zendaya’s “Challengers” was third with $4.7 million and has earned $38 million in three weeks for Amazon MGM studios.

The opening for “Kingdom of the Planet of the Apes,” helmed by “Maze Runner” director Wes Ball, was the second best in the series, after the $72 million opening weekend of 2014’s “Dawn of the Planet of the Apes.”

It’s the 10th movie in the “Planet of the Apes” franchise that began in 1968 with the Charlton Heston original with a twist ending.

“This franchise has never been allowed to lose its momentum,” said Paul Dergarabedian, the senior media analyst for Comscore. “There are very few franchises that have this kind of longevity.”

And it really is the property itself. The new film shares no central actors or characters with its predecessors.

“There’s just this love for the way it melds sci-fi with social commentary and straight-up popcorn entertainment,” Dergarabedian said.

“Kingdom” came with strong reviews and positive buzz (80% fresh on Rotten Tomatoes and a “B” CinemaScore). It was especially praised for its visual effects and the way its CGI has caught up with its primates-on-horseback aesthetic even since the last film, 2017’s “War for the Planet of the Apes.”

Mark Kennedy of The Associated Press called it “thrilling” and “visually stunning.”

The shot in the arm is welcome for the movie business, but there is little certainty in the forthcoming summer.

The year so far, lacking an early Marvel movie like 2023’s “Guardians of the Galaxy Vol. 3,” is running 21% last year’s mid-May total.

While there are potential blockbusters that feel like safe bets including “Despicable Me 4” and “Deadpool & Wolverine” in July, others like “Furiosa: A Mad Max Saga” later this month and “Twisters” later in the summer feel like they could break either way.

Pixar once brought almost guaranteed hits, but June’s “Inside Out 2” may not thrive like the 2015 original.

“There used to be sure bets we cannot necessarily bank on anymore,” Dergarabedian said. “It is going to be a bit of a hit-or-miss slate.”

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Comscore. Final domestic figures will be released Monday.

  1. “Kingdom of the Planet of the Apes,” $56.5 million.

  2. “The Fall Guy,” $13.7 million.

  3. “Challengers,” $4.7 million.

  4. “Tarot,” $3.45 million.

  5. “Godzilla x Kong: The New Empire,” $2.5 million.

  6. “Unsung Hero,” $ 2.25 million.

  7. “Kung Fu Panda 4,” $2 million.

  8. “Civil War,” $1.8 million.

  9. “Star Wars: Episode 1 – The Phantom Menace,” $1.5 million.

  10. “Abigail,” $1.1 million.
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‘The Fall Guy’ gives Hollywood muted summer kickoff with $28.5M opening

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New York — “The Fall Guy,” the Ryan Gosling-led, action-comedy ode to stunt performers, opened below expectations with $28.5 million, according to studio estimates Sunday, providing a lukewarm start to a summer movie season that’s very much to be determined for Hollywood.

The Universal Pictures release opened on a weekend that Marvel has regularly dominated with $100 million-plus launches. (In 2023, that was “Guardians of the Galaxy Vol. 3” with a $118 million debut.) But last year’s strikes jumbled this year’s movie calendar; “Deadpool & Wolverine,” originally slated to open this weekend, is instead debuting in July.

So in place of a superhero kickoff, the summer launch went to a movie about the stunt performers who anonymously sacrifice their bodies for the kind of action sequences blockbusters are built on. Going into the weekend, forecasts had the film opening $30 million to $40 million.

“The Fall Guy,” directed by former stuntman and “Deadpool 2” helmer David Leitch, rode into the weekend with the momentum of glowing reviews and the buzz of a SXSW premiere. But it will need sustained interest to merit its $130 million production budget. It added $25.4 million in overseas markets.

Working in its favor for a long run: strong audience scores (an “A-” CinemaScore) and good reviews (83% fresh on Rotten Tomatoes). Jim Orr, distribution chief for Universal, believes things line up well for “The Fall Guy” in the coming weeks.

“We had a very solid opening,” said Orr. “We’re looking forward to a very long, very robust, very successful run throughout the domestic box office for literally weeks if not months to come.”

But the modest start for “The Fall Guy” hints at larger concerns for the film industry. Superhero films haven’t been quite the box-office behemoth they once were, leading studios to search for fresher alternative. “The Fall Guy” seemed to check all the boxes, with extravagant action sequences, one of the hottest stars in the business, a director with a track-record for crowd pleasers and very good reviews.

But instead, the opening for “The Fall Guy,” loosely based on the 1980s TV series, only emphasized that the movie business is likely to struggle to rekindle the fervor of last year’s “Barbenheimer” summer. “The Fall Guy” stars one from each: Gosling, in his first post-Ken role, and Emily Blunt, of “Oppenheimer.” Both were Oscar nominated.

“It’s going to be a very interesting, nontraditional summer this year,” said Paul Dergarabedian, senior media analyst for Comscore.

In part due to the effects of last year’s work stoppages, there are fewer big movies hitting theaters. Expectations are that the total summer box office will be closer to $3 billion than the $4 billion that’s historically been generated.

“The summer season is just getting started, so let’s give ‘The Fall Guy’ a chance to build that momentum over time. It’s a different type of summer kickoff film,” said Dergarabedian. “There’s always huge expectations placed on any film that kicks off the summer movie season, but this isn’t your typical summer movie season.”

In a surprise, No. 2 at the box office went to the Walt Disney Co. rerelease of “Star Wars: The Phantom Menace.” The first episode to George Lucas’ little-loved prequels collected $8.1 million over the weekend, 25 years after “Phantom Menace” grossed $1 billion.

Last week’s top film, the Zendaya tennis drama “Challengers,” slid to third place with $7.6 million in its second week. That was a sold hold for the Amazon MGM release, directed by Luca Guadagnino, dipping 49% from its first weekend.

The Sony Screen Gems supernatural horror film “Tarot” also opened nationwide. It debuted with $6.5 million, a decent enough start for a low-budget release but another example of horror not quite performing this year as it has the last few years.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Comscore. Final domestic figures will be released Monday.

  1. “The Fall Guy,” $28.5 million.

  2. “Star Wars: The Phantom Menace,” $8.1 million.

  3. “Challengers,” $7.6 million.

  4. “Tarot,” $6.5 million.

  5. “Godzilla x Kong: The New Empire,” $4.5 million.

  6. “Civil War,” $3.6 million.

  7. “Unsung Hero,” $3 million.

  8. “Kung Fu Panda 4,” $2.4 million.

  9. “Abigail,” $2.3 million.

  10. “Ghostbuster: Frozen Empire,” $1.8 million.
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First patient to get gene-edited pig kidney transplant dies 

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Washington — The first living patient to receive a genetically modified pig kidney transplant has died two months after the procedure, the US hospital that carried it out said.

“Mass General is deeply saddened at the sudden passing of Mr. Rick Slayman. We have no indication that it was the result of his recent transplant,” the Boston hospital said in a statement issued late Saturday.

In a world first, surgeons at Massachusetts General Hospital in March successfully transplanted the genetically edited pig kidney into Slayman, who was 62 years old at the time and suffering from end-stage kidney disease.

“Slayman will forever be seen as a beacon of hope to countless transplant patients worldwide and we are deeply grateful for his trust and willingness to advance the field of xenotransplantation,” the hospital statement said.

Organ shortages are a chronic problem around the world and Mass General said in March that there were more than 1,400 patients on its waiting list for a kidney transplant.

The pig kidney used for the transplant was provided by a Massachusetts biotech company called eGenesis and had been modified to remove harmful pig genes and add certain human genes, according to the hospital.

Slayman, who suffered from Type 2 diabetes and hypertension, had received a transplanted human kidney in 2018, but it began to fail five years later.

When the hospital announced the successful transplant in March, Slayman said he had agreed to the procedure “not only as a way to help (him), but a way to provide hope for the thousands of people who need a transplant to survive.”

In a statement posted on Mass General’s website, his family said while they were “deeply saddened about the sudden passing of our beloved Rick” they took “great comfort knowing he inspired so many.”

The family said they were “comforted by the optimism he provided patients desperately waiting for a transplant”.

More than 89,000 patients were on the national kidney waiting list as of March this year, according to a US health department website.

On average, 17 people die each day while waiting for an organ transplant.

Slayman’s family also thanked the doctors “who truly did everything they could to help give Rick a second chance. Their enormous efforts leading the xenotransplant gave our family seven more weeks with Rick, and our memories made during that time will remain in our minds and hearts.”

“After his transplant, Rick said that one of the reasons he underwent this procedure was to provide hope for the thousands of people who need a transplant to survive,” the family added.

“His legacy will be one that inspires patients, researchers, and health care professionals.”

The transplantation of organs from one species to another is a growing field known as xenotransplantation.

About a month after Slayman’s procedure, surgeons at NYU Langone Health in New York carried out a similar transplant on Lisa Pisano, who had suffered heart failure and end-stage kidney disease.

Pig kidneys had been transplanted previously into brain-dead patients, but Slayman was the first living person to receive one.

Genetically modified pig hearts were transplanted in 2023 into two patients at the University of Maryland, but both lived less than two months.

Mass General said Slayman’s transplant had been carried out under a policy known as “compassionate use” that allows patients with “serious or life-threatening conditions” to access experimental therapies not yet approved by the US Food and Drug Administration.
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Prada focuses generational transition on Italian artisans

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TORGIANO, Italy — The Prada Group is expanding its production footprint in Italy, including dozens of new jobs at its knitwear factory in Umbria, leaning into “Made in Italy” as integral to the brand’s ethos and developing new artisanal talent to ease the luxury group through a generational shift in its workforce.

Prada CEO Andrea Guerra, who was brought in last year as part of the generational change in family-run Prada’s management, said at an unveiling of the expanded plant Tuesday that the company is investing 60 million euros ($65 million) in production this year.

At Torgiano, Prada has added 30 new jobs this year, alongside 65 last year, bringing the workforce to some 220 employees, mostly women, to create knitwear for the Prada and Miu Miu brands, a key category for the group. The site had just 39 employees when Prada bought it in 2001.

“For many years, Torgiano was a small, important place, linked to the Umbrian knitwear tradition,” mostly dedicated to product research and development, Guerra said. “In the last six or seven years, with the extraordinary growth in knitwear, we decided to create an all-around industrial hub,” adding production to a reinforced R&D center.

The innocuous low-slung plant, identified by a simple, small Prada nameplate near the gate, is at the heart of a network that includes dozens of smaller companies that together create some 30,000 pieces of knitwear a month for the global luxury group. They include red crocheted Miu Miu culottes to soft gray Prada cardigans that have become a trademark.

Guerra described the Milan-based fashion group’s manufacturing footprint in central Italy as a “network of intelligent relationships and craftsmanship merged with a constant capacity to bring innovation to the market.”

Prada’s investments to exert greater control over its supply chain stand out against the backdrop of a recent investigation that revealed sweatshop conditions in Chinese-owned factories producing luxury goods for other Italian brands in the Lombardy region, where the Italian fashion capital Milan is located. The production arm of Giorgio Armani has been put under receivership as part of an ongoing supply chain probe.

Prada has focused on what it calls vertical integration of its supply chain — working with smaller companies, some with just a handful of craftspeople, that provide specific, sometimes unique, skills. For its knitwear operation, Prada works with some 60 smaller companies that it refers to as “partners” or “collaborators.”

“Contractors, subcontractors, that is not something tied to this world. There are production phases that are assigned to our collaborators, our partners,” Guerra said, adding: “The way I work inside, and the way I work outside needs to be the same.”

Lorenzo Bertelli, marketing director and head of corporate social responsibility who is slated to take over the company from his parents Patrizio Bertelli and Miuccia Prada, said a strong governance is the key to avoiding “such incidents.” He credited his father with starting Prada on the road to integrating its supply chain in the 1990s.

Audits of suppliers, which have so far been voluntary, will become mandatory in 2025 under the Corporate Sustainability Reporting legislation, aimed at controlling abuses, said Stefania Saviolo, a fashion and luxury expert at Milan’s Bocconi University. Publicly quoted companies like Prada, which are used to a level of transparency and reporting, will likely have an easier time than others, she said.

Integrating the supply chain doesn’t just mean that a major player buys up smaller companies, she said, but they may invest in specific machinery, or help them secure bank financing. “It is not ownership, it is a longer transaction along the model of partnership,” Saviolo said, adding that such relationships also provide a sense of security to the smaller companies more vulnerable to market crashes.

Noting that the luxury and fashion industries have long relied on third-party manufacturing, Bernstein global luxury goods analyst Luca Solca said the kind of investments by Prada to integrate manufacturing processes in-house “is a sort of catch-up with best-in-class-players in the industry.”

A key part of Prada’s investments are aimed at securing know-how into the next generation, a transition the company has been preparing also in its management and creative roles.

Finding new workers with both experience and passion is difficult, even in a region where knitwear is part of the local tradition, said Lorenzo Teodori, who runs the Torgiano plant.

To fill that gap, Prada runs an internal academy as needed at its 23 Italian production sites to train young craftspeople. The next one in Torgiano starts in the fall, with experienced workers training the next generation.

“Through the Prada Academy, we have seen how this dialogue is still alive and successful,” Bertelli said. “We need it to train the future technicians of tomorrow, who in turn will be the teachers in the future. It is a fundamental cycle for our group.”
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Dogs entering US must be 6 months old, microchipped to prevent rabies spread

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New York — All dogs coming into the U.S. from other countries must be at least 6 months old and microchipped to help prevent the spread of rabies, according to new government rules published Wednesday.

The new rules require vaccination for dogs that have been in countries where rabies is common. The update applies to dogs brought in by breeders or rescue groups as well as pets traveling with their U.S. owners.

“This new regulation is going to address the current challenges that we’re facing,” said Emily Pieracci, a rabies expert at the Centers for Disease Control and Prevention who was involved in drafting the updated regulations.

The CDC posted the new rules in the federal register on Wednesday. They take effect Aug. 1 when a temporary 2021 order expires. That order suspended bringing in dogs from more than 100 countries where rabies is still a problem.

The new rules require all dogs entering the U.S. to be at least 6 months, old enough to be vaccinated if required, and for the shots to take effect; have a microchip placed under their skin with a code that can be used to verify rabies vaccination; and have completed a new CDC import form.

There may be additional restrictions and requirements based on where the dog was the previous six months, which may include blood testing from CDC-approved labs.

The CDC regulations were last updated in 1956, and a lot has changed, Pieracci said. More people travel internationally with their pets, and more rescue groups and breeders have set up overseas operations to meet the demand for pets, she said. Now, about 1 million dogs enter the U.S. each year.

Dogs were once common carriers of the rabies virus in the U.S. but the type that normally circulates in dogs was eliminated through vaccinations in the 1970s. The virus invades the central nervous system and is usually a fatal disease in animals and humans. It’s most commonly spread through a bite from an infected animal. There is no cure for it once symptoms begin.

Four rabid dogs have been identified entering the U.S. since 2015, and officials worried more might get through. CDC officials also were seeing an increase of incomplete or fraudulent rabies vaccination certificates and more puppies denied entry because they weren’t old enough to be fully vaccinated.

A draft version of the updated regulations last year drew a range of public comments.

Angela Passman, owner of a Dallas company that helps people move their pets internationally, supports the new rules. It can especially tricky for families that buy or adopt a dog while overseas and then try to bring it to the U.S., she said. The update means little change from how things have been handled in recent years, she said.

“It’s more work for the pet owner, but the end result is a good thing,” said Passman, who is a board member for the International Pet and Animal Transportation Association.

But Jennifer Skiff said some of the changes are unwarranted and too costly. She works for Animal Wellness Action, a Washington group focused on preventing animal cruelty that helps organizations import animals.

She said those groups work with diplomats and military personnel who have had trouble meeting requirements, and was a reason some owners were forced to leave their dogs behind.
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